Camptothecin (NSC-100880)

For research use only.

Catalog No.S1288 Synonyms: CPT, Campathecin, (S)-(+)-Camptothecin

84 publications

Camptothecin (NSC-100880) Chemical Structure

CAS No. 7689-03-4

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.

Selleck's Camptothecin (NSC-100880) has been cited by 84 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Targets
Topo I [2]
(Cell-free assay)
0.68 μM
In vitro

Camptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin displays nanomolar potency in cytotoxicity against many human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB, with IC50 values ranging from 37 nM to 48 nM. [2] In combination with TNF, Camptothecin induces apoptosis in primary mouse hepatocytes, with an IC50 value of 13 μM. Camptothecin also abrogated the TNF-induced NF-κB Activation, as well as the expression of TNF-receptor associated factor 2 (TRAF2), X-linked inhibitor of apoptosis protein (X-IAP), and FLICE-inhibitory protein (FLIP). [4] In HCT116 cells, Camptothecin (5 μM) induces proteasome-mediated degradation of mixed lineage leukemia 5 (MLL5) protein, which leads to phosphorylation of p53 at Ser392. [5] Due to the low solubility and adverse effects of Camptothecin, various Camptothecin analogues have been developed, and two of them, topotecan and irinotecan, has been approved by FDA and are used in cancer chemotherapy.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 NXLRVIpTT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NF;lUYhKSzVyPUOyJI5O MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODN2NkmzN{c,OTB|NE[5N|M9N2F-
P388CPT5 R NG\OUGJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MWrJR|UxRTJwODFOwG0> M3PLO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{S2PVM{Lz5zMEO0Olk{OzxxYU6=
KBwt NYfUPXNoT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= Mnv4TWM2OD12MDDuUS=> NUDJ[WM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KBMDR NGrXd4RIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVPJR|UxRTdyIH7N NX:1SohCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KBV20C NWHaOZVPT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MmiwTWM2OD1|MDDuUS=> NXrsbY5wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KB7D M{LnRmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NIi3Om9KSzVyPUO1JI5O MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
KBCamp NFLMcpRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NV;sTZloUUN3ME2xMlA1KM7:TR?= Ml2xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB2MUG0O|YoRjFyNEGxOFc3RC:jPh?=
HT29 M1ewc4N6fG:2b4jpZ4l1gSCjc4PhfS=> NVvQV4VqUUN3ME24NEBvVQ>? M3rqV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
A549 NHfOcJhkgXSxdH;4bYNqfHliYYPzZZk> MlvSTWM2OD14NzDuUS=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh2MUiwPEc,OTB6NEG4NFg9N2F-
T24 NYTBSGM4[3m2b4TvfIlkcXS7IHHzd4F6 M4PjXGlEPTB;OEigcm0> M16wXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
HOP-62 M1vCb2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NWjQPIFJUUN3ME2xNEBvVQ>? NI\2N3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
HCT-116 MoPUS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NYnNb5o6UUN3ME2zNEBvVQ>? MmSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
SF-539 MVLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NUDoXFN{UUN3ME2xNEBvVQ>? NID0S5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
UACC-62 NFn6O|BIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3vhOmlEPTB;MUCgcm0> NITHeos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
OVCAR-3 MWfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MWLJR|UxRTJ{MDDuUS=> Mnj4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
SN12C NV\Nbmk3T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MmTiTWM2OD1{MDDuUS=> Mor4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
DU-145 M3jvSGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NWDmfXlPUUN3ME2xNEBvVQ>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
MDA-MB-435 MWDHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MlnVTWM2OD12MDDuUS=> MlXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
WiDr MYnjfZRwfG:6aXPpeJkh[XO|YYm= NIG2cplFVVOR MmnHTWM2OD1zNzDuUS=> M1y2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
A549 MnvTZ5l1d3SxeHnjbZR6KGG|c3H5 M1PmdWROW09? NWTDe|dwUUN3ME2xOEBvVQ>? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
MKN45 MUHjfZRwfG:6aXPpeJkh[XO|YYm= MX3EUXNQ MVfJR|UxRTF5IH7N NHzYPGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOzOFU3QSd-MUGzN|Q2Pjl:L3G+
SK-OV-3 NGS4TYtkgXSxdH;4bYNqfHliYYPzZZk> NVP6PZJmTE2VTx?= M4TWV2lEPTB;MkCgcm0> MnO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
H128 NU\uVJdE[3m2b4TvfIlkcXS7IHHzd4F6 MWHEUXNQ MXrJR|UxRTF6IH7N NF;uTWY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOzOFU3QSd-MUGzN|Q2Pjl:L3G+
SK-BR-3 MYnjfZRwfG:6aXPpeJkh[XO|YYm= NVixdpliTE2VTx?= M4fpfWlEPTB;MkCgcm0> MlTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
LX-1 M37nToN6fG:2b4jpZ4l1gSCjc4PhfS=> M13uWWROW09? NYLteW5nUUN3ME2xNlAhdk1? NGLtS489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUi1PFc{Pyd-MUG4OVg4Ozd:L3G+
HCT116 NVXJd29w[3m2b4TvfIlkcXS7IHHzd4F6 MXPEUXNQ NFLUb5BKSzVyPUmgcm0> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTh3OEezO{c,OTF6NUi3N|c9N2F-
A2780 NWnIeINJ[3m2b4TvfIlkcXS7IHHzd4F6 NWnD[ZlpTE2VTx?= MnLRTWM2OD12IH7N NFTZTpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUi1PFc{Pyd-MUG4OVg4Ozd:L3G+
IMR-32 MVjjfZRwfG:6aXPpeJkh[XO|YYm= NWfuRXhmhjFyIN88US=> Mmq2SG1UVw>? NUTk[oUzUUN3ME2yMlIyKG6P M3PsOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkG3PFk1Lz5zMk[xO|g6PDxxYU6=
P388 MYLjfZRwfG:6aXPpeJkh[XO|YYm= M1\Pd2lEPTB;MUOgcm0> NXTyWJBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2NlAxQDFpPkGyOlIxODhzPD;hQi=>
Lewis Ml31Z5l1d3SxeHnjbZR6KGG|c3H5 NXu4eldjUUN3ME2zN{BvVQ>? NUTw[257RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2NlAxQDFpPkGyOlIxODhzPD;hQi=>
JLC NV61Xo4{[3m2b4TvfIlkcXS7IHHzd4F6 NUXTUVBpUUN3ME21MlYhdk1? MkHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
HT-29 M4TH[YN6fG:2b4jpZ4l1gSCjc4PhfS=> MUPJR|UxRTFwNDFOwG0> MofPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4M{m1OFEoRjF{NkO5OVQyRC:jPh?=
Caki-2 NXW0Xnh2[3m2b4TvfIlkcXS7IHHzd4F6 M3HUWGlEPTB;Mz65OkDPxE1? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
A549 M1;iS4N6fG:2b4jpZ4l1gSCjc4PhfS=> MmnJTWM2OD1{LkWzJO69VQ>? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
HEC-1-B NXvpbI82[3m2b4TvfIlkcXS7IHHzd4F6 M2fke2lEPTB;OD62OEDPxE1? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
HL-60 M2PEWIN6fG:2b4jpZ4l1gSCjc4PhfS=> NXrRVmI4UUN3ME22OkBvVQ>? MoOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4M{m1OFEoRjF{NkO5OVQyRC:jPh?=
Col2 NFHTSZFkgXSxdH;4bYNqfHliYYPzZZk> M2fER54yKM7:TR?= M3vufmVFPTB;NUegcm0> NETuN4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
HUVEC NXu5XmQy[3m2b4TvfIlkcXS7IHHzd4F6 MoH3glEh|ryP MVLFSFUxRTJ3ODDuUS=> MmDPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
KB MW\jfZRwfG:6aXPpeJkh[XO|YYm= MWL+NUDPxE1? MYXFSFUxRTJ{IH7N NIflSYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
LCNaP NEH5dZlkgXSxdH;4bYNqfHliYYPzZZk> NVHxe3V{hjFizszN MmmzSWQ2OD1{ODDuUS=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
Lu1 MYLjfZRwfG:6aXPpeJkh[XO|YYm= NH7oR41,OSEQvF2= MkfJSWQ2OD1{OTDuUS=> NGrxdXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
RPMI8402 MkX5Z5l1d3SxeHnjbZR6KGG|c3H5 M{PQep4yOCEQvF2= Moi0TWM2OD14IH7N NVjDT4hORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
CPT-K5 NXjKSpZI[3m2b4TvfIlkcXS7IHHzd4F6 M1HQbp4yOCEQvF2= MlfwTWM2OD5zMDFOwG0> MkfVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
P388 MnPjZ5l1d3SxeHnjbZR6KGG|c3H5 NVPNUYhZhjFyIN88US=> NF:4WnVKSzVyPUG0JI5O NUXrT5JORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
P388/CPT45 Mn24Z5l1d3SxeHnjbZR6KGG|c3H5 MlO1glExKM7:TR?= NV\6VlF2UUN3ME6xNEDPxE1? NWTkOFA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
KB3-1 NX61OZhQ[3m2b4TvfIlkcXS7IHHzd4F6 NGi4[ZN,OTBizszN MXvJR|UxRTRyIH7N M4iyN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
KBV-1 + MDR1 M1TmfoN6fG:2b4jpZ4l1gSCjc4PhfS=> NFH4PI5,OTBizszN NVvoVXJJUUN3ME20OFAhdk1? NV3uXm9ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
KBH M1K3eYN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml7HglExKM7:TR?= NYHKbIhEUUN3ME20OFAhdk1? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
HOP-62 NVXCN5B{[3m2b4TvfIlkcXS7IHHzd4F6 M4fjRZ4yOCEQvF2= MnHDS2k2OD1zMDDuUS=> NHi4TXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
HCT-116 MYXjfZRwfG:6aXPpeJkh[XO|YYm= MU\+NVAh|ryP M2[4S2dKPTB;M{Cgcm0> MnLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxOlQoRjF3NUC5NVY1RC:jPh?=
F-539 MUnjfZRwfG:6aXPpeJkh[XO|YYm= M2DPTp4yOCEQvF2= MnzaS2k2OD1zMDDuUS=> M2n1[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
UACC-62 NYLPTJh5[3m2b4TvfIlkcXS7IHHzd4F6 M3z1UZ4yOCEQvF2= NH\aWYhIUTVyPUGwJI5O NYPMcZhORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPjRpPkG1OVA6OTZ2PD;hQi=>
OVCAR-3 Mln5Z5l1d3SxeHnjbZR6KGG|c3H5 MX7+NVAh|ryP M4\qXWdKPTB;MkKwJI5O NFXL[mY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
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HT-29 MlHqR5l1d3SxeHnjbZR6KGG|c3H5 Moe3OFghcHK| NVriPGpES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiZYjwdoV{e2mwZzDwOVMhdXW2YX70JIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD60{txONg>? M3Sxc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{G1N|E6Lz5zOUexOVMyQTxxYU6=
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HT-29 MXLDfZRwfG:6aXPpeJkh[XO|YYm= MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{whTUN3ME2wMlA3|ryPLh?= NUnx[lBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NlUzODZpPkKwPFI2OjB4PD;hQi=>
HT-29 Ml;2R5l1d3SxeHnjbZR6KGG|c3H5 M1PLPVMh\GG7cx?= NXPmUVNCS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGVFPTB;MD6wOu69VS5? NGLzdHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEmzPVU1OCd-MkC5N|k2PDB:L3G+
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A172 NIfHToNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU[yOEBpenN? NFXLWnRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCOTd{IHPlcIx{KHWyIITvJFI2KHWPIHPveJJm[XSnZDD3bZRpKGOxbHPobYNqdmVibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KFiWVDDhd5NigQ>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDdzMEm2Nkc,Ojh5MUC5OlI9N2F-
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HCT116 MlnWR5l1d3SxeHnjbZR6KGG|c3H5 MlvtO|IhcHK| MoDFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OS56ON88UU4> MkD5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7MkOzPFgoRjJ6OUKzN|g5RC:jPh?=
Hep2 MVPDfZRwfG:6aXPpeJkh[XO|YYm= M37oO|czKGi{cx?= NYDleHZVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTNwMEVOwG0v NI[2NYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|M5QCd-Mki5NlM{QDh:L3G+
A549 NVvlZ5dJS3m2b4TvfIlkcXS7IHHzd4F6 Mlr4O|IhcHK| NV;zZ|RYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTVwOUROwG0v MkLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7MkOzPFgoRjJ6OUKzN|g5RC:jPh?=
A549 MkG0R5l1d3SxeHnjbZR6KGG|c3H5 MXS3NkBpenN? NGXYN2REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xODh4M988UU4> NWfWeFRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc4QTBpPkK4PVI4PzlyPD;hQi=>
KBVIN NIfxZ3BEgXSxdH;4bYNqfHliYYPzZZk> MkC1O|IhcHK| MYfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRnZKViClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFE2P87:TT6= M4XIVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3O|kxLz5{OEmyO|c6ODxxYU6=
KB NWTzUVlHS3m2b4TvfIlkcXS7IHHzd4F6 MYO3NkBpenN? M4S2XGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wOe69VS5? NUfuTYZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc4QTBpPkK4PVI4PzlyPD;hQi=>
MCF7 MYrDfZRwfG:6aXPpeJkh[XO|YYm= Mn36O|IhcHK| MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6wPFc2|ryPLh?= M2DDWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3O|kxLz5{OEmyO|c6ODxxYU6=
MDA-MB-231 MoPTR5l1d3SxeHnjbZR6KGG|c3H5 MUS3NkBpenN? NUi3NW1KS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuN|A4|ryPLh?= MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{e5NEc,Ojh7Mke3PVA9N2F-
HL60 NFXkeZJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NE\WO2U4OiCqcoO= NUnLNWNiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTD0dplxcGGwIHLseYUhe3SjaX7pcoch[mG|ZXSgbIVu[XSxY4n0c41mfHKrYzDt[ZRpd2RuIFnDOVA:OC57Mt88UU4> NH:1b5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGzNVYyPid-MkmxN|E3OTZ:L3G+
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HL60 MX;DfZRwfG:6aXPpeJkh[XO|YYm= MV:0PEBpenN? M{\2c2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhNPjBiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCDVGDsbZRmNWKjc3XkJIx2dWmwZYPj[Y51KGG|c3H5MEBKSzVyPUCuNFLPxE1w MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
HL60 MXfBdI9xfG:|aYOgZZN{[Xl? M{DPfFI1KGi{cx?= NH;OR2dKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFjMOlAh[2WubIOgZZN{\XO|ZXSgZZMh[2G|cHHz[UA{NzdiYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KGOjc4Dhd4Uu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDJR|UxRTBwMEhOwG0v NGHzZoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|A6QSd-MkmyNlMxQTl:L3G+
K562 Mn23R5l1d3SxeHnjbZR6KGG|c3H5 NHHIeZo1QCCqcoO= M1:1OmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCDVGDsbZRmNWKjc3XkJIx2dWmwZYPj[Y51KGG|c3H5MEBKSzVyPUCuNFnPxE1w NIrGU5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|A6QSd-MkmyNlMxQTl:L3G+
MCF7 MXnDfZRwfG:6aXPpeJkh[XO|YYm= NFHBRWY1QCCqcoO= MmT6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KEGWUHzpeIUu[mG|ZXSgcJVucW6nc3PlcpQh[XO|YYmsJGlEPTB;MD6zOO69VS5? NXTmU3dORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNlMxQTlpPkK5NlI{ODl7PD;hQi=>
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HepG2 MXHDfZRwfG:6aXPpeJkh[XO|YYm= NITGOXk1QCCqcoO= NVzWZW1wS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDBWHBtcXSnLXLhd4VlKGy3bXnu[ZNk\W62IHHzd4F6NCCLQ{WwQVAvPDQQvF2u MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
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LN229 MXrDfZRwfG:6aXPpeJkh[XO|YYm= MUC0PEBpenN? NF;Vc3dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNVjJ{OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhS0ONODDhd5NigSxiSVO1NF0xNjByMEOy{txONg>? M3jCZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyN{CyNlg3Lz5|MEewNlI5PjxxYU6=
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VACO 241 Mlu4SpVv[3Srb36gZZN{[Xl? NFiySlJKdmirYnn0bY9vKG:oIFTORUB1d3CxaYPvcYVz[XOnIEGgbY4hUG:vbzDzZZBq\W6|IDjoeY1idiliVlHDU{AzPDFiY3XscJMtKEmFNUC9OE46Pc7:TT6= NUX2dJRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
SAS NUmyPYE3SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MUK3NkBpenN? MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFODUzDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ou69VS5? NUjTSZU4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
MDA-MB-231 MlXJR5l1d3SxeHnjbZR6KGG|c3H5 NVHaXYxMPDhiaILz NGO2O4dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MU[uOFTPxE1w MmK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
PC3 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MlX4OFghcHK| NIXyVYNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xPE4zPM7:TT6= NGfsN3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
AGS M4TxTGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M4fa[FczKGi{cx?= NGDkSGFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFHHV{Bk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OjNwN{dOwG0v M2TQclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
MCF7 Mlr1SpVv[3Srb36gZZN{[Xl? NIfzZZkyOCC3TR?= MlzONVIhcHK| NFv1bYlRd2m|b37pcoch[WO2aY\peJkh[XRidH;wc4l{d22ncnHz[UAyKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOTJiaILzJIJ6KGmvbYXuc4JidmRiZHXwcIV1cW:wIHHzd4F6 NFfw[Wo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
A549 NYDGc2pHSXCxcITvd4l{KGG|c3H5 Ml:2NVIhfG9iMUWgbJJ{ NYPub2htUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KG[xcn3heIlwdiCxZjDhdI9xfG:2aXOgZo9lcWW|IHHmeIVzKDF{IITvJFE2KGi{czDifUBndG:5IHP5eI9u\XS{aXOgcYV1cG:m MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OU8oRkOqRV3CUFww[T5?
A549 NI\PS21CeG:ydH;zbZMh[XO|YYm= NVHoT|lrOTJidH:gNVUhcHK| NUG1[o04UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygZ49v\GWwc3H0bY9vKGGodHXyJFEzKHSxIEG1JIhzeyCkeTDmcI94KGO7dH;t[ZRzcWNibXX0bI9l M2HPWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
MDA-MB-231 NGn5c3FE\WyuIHP5Z4xmKGG|c3H5 NGXQbVYyKHWP NGjORngyPiCqcoO= NUHjO2RPS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhWy2yaHHz[UBifCBzIIXNJIlv[3WkYYTl[EBnd3JiMU[gbJJ{KGK7IH\sc5ch[3m2b33leJJ6 Ml7YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin1 / CDK1 / CDK2 ; 

PubMed: 29963130     


Western blot analysis indicated that camptothecin (6 µM) downregulates the expression of cell-cycle-associated proteins, cyclin 1, CDK1 and CDK2 in NPC cells. β-actin was used as a loading control.

Vimentin / Fibronectin / E-cadherin ; 

PubMed: 29963130     


Western blot analysis revealed that camptothecin (6 µM) treatment downregulates the expression of vimentin and fibronectin, and upregulates the expression of E-cadherin in NPC cells. β-actin was used as a loading control. NPC, nasopharyngeal carcinoma.

TGF-β / PI3K / pPI3K / AKT / pAKT ; 

PubMed: 29963130     


Western blot analysis revealed that camptothecin (6 µM) treatment inhibits the expression of TGF-β, PI3K and AKT in NPC cells. 

p53 / Cleaved caspase-3 / Cleaved PARP ; 

PubMed: 17548347     


NPCs in trophic factor-containing media were treated with 10 μM camptothecin for 0, 2, 4, 6, or 8 h, and extracts were immunoblotted for p53, active cleaved caspase-3, cleaved PARP, and total GSK3α/β as a loading control.

29963130 17548347
In vivo Camptothecin (8 mg/kg) displays complete growth inhibition and regression in mice xenografts of various tumors, including colon, lung, breast, stomach, and ovary tumors. [3] In mice, combinations of Camptothecin (50 mg/kg) and TNF (5 and 7 μg/kg), but not Camptothecin alone, induces liver damage. [4]

Protocol

Kinase Assay:[2]
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Topoisomerase I Cleavable Complex Assay:

Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine
Cell Research:[2]
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  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 0.17 nM–10 mM
  • Incubation Time: 48 hours
  • Method: Tumor cells are plated in 100 μL of medium in 96-well microtiter plates at a density of 1500 to 4000 cells per well and allowed to adhere overnight. Cells are incubated with Camptothecin for 48 hours and then with fresh medium for 48 hours. Camptothecin at each concentration is added in quadruplicate. Following a 4-hour incubation of treated cells with MTT, the reduced dye product is extracted from the cells with 0.2 mL of DMSO followed by 50 μL of Sorensen's buffer. The plates are shaken briefly, and the absorbance at 570 nm is read and quantitated. Curves are fitted to the MTT assay data using a four-parameter logistic equation.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Nude mice (NIH-I high fertility strain) bearing xenografts of CASE, SW48, DOY, SPA, and CLO cells
  • Dosages: 0–8 mg/kg
  • Administration: Administered via i.m. or i.v. injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 3 mg/mL (8.61 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.35
Formula

C20H16N2O4

CAS No. 7689-03-4
Storage powder
in solvent
Synonyms CPT, Campathecin, (S)-(+)-Camptothecin
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04419272 Not yet recruiting Drug: Methylphenidate|Other: Placebo Epilepsy VA New York Harbor Healthcare System|Portland VA Medical Center|Miami VA Healthcare System April 2022 Phase 4
NCT05000905 Not yet recruiting Behavioral: Adaptive Attention Training Pediatric Cancer University of California San Francisco January 1 2022 Not Applicable
NCT04077281 Not yet recruiting Other: Medication Coordinated care Patient Discharge|Drug-Related Side Effects and Adverse Reactions|Aged|Health Care Costs St. Joseph''s Healthcare Hamilton|Canadian Institutes of Health Research (CIHR) November 2021 Not Applicable
NCT04568616 Not yet recruiting Drug: Letrozole 2.5mg Breast Cancer|ER Positive Breast Cancer Dartmouth-Hitchcock Medical Center September 2021 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID