Camptothecin (NSC-100880)

For research use only.

Catalog No.S1288 Synonyms: CPT, Campathecin, (S)-(+)-Camptothecin

82 publications

Camptothecin (NSC-100880) Chemical Structure

CAS No. 7689-03-4

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.

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10mM (1mL in DMSO) GBP 114 In stock
GBP 63 In stock
GBP 90 In stock
GBP 139 In stock
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Selleck's Camptothecin (NSC-100880) has been cited by 82 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Targets
Topo I [2]
(Cell-free assay)
0.68 μM
In vitro

Camptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin displays nanomolar potency in cytotoxicity against many human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB, with IC50 values ranging from 37 nM to 48 nM. [2] In combination with TNF, Camptothecin induces apoptosis in primary mouse hepatocytes, with an IC50 value of 13 μM. Camptothecin also abrogated the TNF-induced NF-κB Activation, as well as the expression of TNF-receptor associated factor 2 (TRAF2), X-linked inhibitor of apoptosis protein (X-IAP), and FLICE-inhibitory protein (FLIP). [4] In HCT116 cells, Camptothecin (5 μM) induces proteasome-mediated degradation of mixed lineage leukemia 5 (MLL5) protein, which leads to phosphorylation of p53 at Ser392. [5] Due to the low solubility and adverse effects of Camptothecin, various Camptothecin analogues have been developed, and two of them, topotecan and irinotecan, has been approved by FDA and are used in cancer chemotherapy.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 MoXYS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MnqyTWM2OD1|MjDuUS=> NVjwO25CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCzOFY6OzNpPkGwN|Q3QTN|PD;hQi=>
P388CPT5 R NXzTWIYyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NIXaN5JKSzVyPUKuPEDPxE1? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODN2NkmzN{c,OTB|NE[5N|M9N2F-
KBwt NFriUZhIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NY\zVXNxUUN3ME20NEBvVQ>? NY[0RYFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KBMDR MXPHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NWfq[nhRUUN3ME23NEBvVQ>? M1u0PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNEGxOFc3Lz5zMESxNVQ4PjxxYU6=
KBV20C NF7GOotIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MWrJR|UxRTNyIH7N NWPkSHZPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KB7D Mn;RS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NX7iWHhWUUN3ME2zOUBvVQ>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
KBCamp NFT5[Y5Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NFn5doNKSzVyPUGuNFQh|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
HT29 Mmj3Z5l1d3SxeHnjbZR6KGG|c3H5 M1zMb2lEPTB;OECgcm0> NXnJe4N[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4OFE5ODhpPkGwPFQyQDB6PD;hQi=>
A549 NFjwS5hkgXSxdH;4bYNqfHliYYPzZZk> MlrjTWM2OD14NzDuUS=> NH3XV4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi0NVgxQCd-MUC4OFE5ODh:L3G+
T24 NF7Y[nFkgXSxdH;4bYNqfHliYYPzZZk> MUTJR|UxRTh6IH7N NEfybVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi0NVgxQCd-MUC4OFE5ODh:L3G+
HOP-62 M2rIb2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MlHaTWM2OD1zMDDuUS=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
HCT-116 M3PKWmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MXnJR|UxRTNyIH7N Mn7PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
SF-539 MX7Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MkT1TWM2OD1zMDDuUS=> M3LEOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
UACC-62 NXzlPG82T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NVuxVIVxUUN3ME2xNEBvVQ>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
OVCAR-3 MUDHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MV;JR|UxRTJ{MDDuUS=> M1TRNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
SN12C M3T3dGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M1fIXGlEPTB;MkCgcm0> M2PzUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
DU-145 MnjWS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWSydXJmUUN3ME2xNEBvVQ>? M{fTTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
MDA-MB-435 M4nDS2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 Mn3BTWM2OD12MDDuUS=> NEPpbWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
WiDr NH;j[JRkgXSxdH;4bYNqfHliYYPzZZk> NGPSRYhFVVOR NXH0TlJyUUN3ME2xO{BvVQ>? Ml;PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
A549 MljDZ5l1d3SxeHnjbZR6KGG|c3H5 MV3EUXNQ M{PUUGlEPTB;MUSgcm0> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
MKN45 NFLKWVVkgXSxdH;4bYNqfHliYYPzZZk> MYDEUXNQ NIXx[GxKSzVyPUG3JI5O NWn1RmtyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjlpPkGxN|M1PTZ7PD;hQi=>
SK-OV-3 NH3tOFlkgXSxdH;4bYNqfHliYYPzZZk> MWjEUXNQ M3;PcGlEPTB;MkCgcm0> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
H128 MkjoZ5l1d3SxeHnjbZR6KGG|c3H5 M4P1WGROW09? NEewS2FKSzVyPUG4JI5O NFPRboY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOzOFU3QSd-MUGzN|Q2Pjl:L3G+
SK-BR-3 NGf2c|FkgXSxdH;4bYNqfHliYYPzZZk> MVjEUXNQ NGD6[2hKSzVyPUKwJI5O MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
LX-1 MYDjfZRwfG:6aXPpeJkh[XO|YYm= MW\EUXNQ MlHJTWM2OD1zMkCgcm0> NF;qe|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUi1PFc{Pyd-MUG4OVg4Ozd:L3G+
HCT116 NGHEVYtkgXSxdH;4bYNqfHliYYPzZZk> MWLEUXNQ MnK1TWM2OD17IH7N NUSzfFRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG4OVg4OzdpPkGxPFU5PzN5PD;hQi=>
A2780 MUfjfZRwfG:6aXPpeJkh[XO|YYm= M4jreGROW09? MYrJR|UxRTRibl2= NVPwN2VbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG4OVg4OzdpPkGxPFU5PzN5PD;hQi=>
IMR-32 M2r0XIN6fG:2b4jpZ4l1gSCjc4PhfS=> M136bJ4yOCEQvF2= MVnEUXNQ M3zNOWlEPTB;Mj6yNUBvVQ>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZzN{i5OEc,OTJ4MUe4PVQ9N2F-
P388 NVrrRmhu[3m2b4TvfIlkcXS7IHHzd4F6 MlKzTWM2OD1zMzDuUS=> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ{MEC4NUc,OTJ4MkCwPFE9N2F-
Lewis MoLCZ5l1d3SxeHnjbZR6KGG|c3H5 NFPUeG5KSzVyPUOzJI5O MkTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
JLC NFv2eGpkgXSxdH;4bYNqfHliYYPzZZk> M{fsZ2lEPTB;NT62JI5O MmDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
HT-29 NF;EOoRkgXSxdH;4bYNqfHliYYPzZZk> MXTJR|UxRTFwNDFOwG0> NGP2XIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[zPVU1OSd-MUK2N|k2PDF:L3G+
Caki-2 MVXjfZRwfG:6aXPpeJkh[XO|YYm= NFXmS5lKSzVyPUOuPVYh|ryP NX:yclBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
A549 NV\sfHdv[3m2b4TvfIlkcXS7IHHzd4F6 NFvRZo9KSzVyPUKuOVMh|ryP NV;6XnpGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
HEC-1-B NWe3NWZs[3m2b4TvfIlkcXS7IHHzd4F6 MmLlTWM2OD16Lk[0JO69VQ>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
HL-60 Mmn4Z5l1d3SxeHnjbZR6KGG|c3H5 MWPJR|UxRTZ4IH7N MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
Col2 NYnZfmdb[3m2b4TvfIlkcXS7IHHzd4F6 NYrNbmo4hjFizszN Mne2SWQ2OD13NzDuUS=> M4LWWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
HUVEC NFTCTJFkgXSxdH;4bYNqfHliYYPzZZk> NFzxUJN,OSEQvF2= NE\tcIdGTDVyPUK1PEBvVQ>? NXX4SZVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
KB MUnjfZRwfG:6aXPpeJkh[XO|YYm= MofhglEh|ryP NV[5VYdUTUR3ME2yNkBvVQ>? NHPlZVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
LCNaP M1LKZoN6fG:2b4jpZ4l1gSCjc4PhfS=> NVfYWmhPhjFizszN Mk[3SWQ2OD1{ODDuUS=> MnKxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
Lu1 NHTqNZdkgXSxdH;4bYNqfHliYYPzZZk> MkPBglEh|ryP M{HXWmVFPTB;Mkmgcm0> M3zZdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
RPMI8402 NEHsdIxkgXSxdH;4bYNqfHliYYPzZZk> MWL+NVAh|ryP NIXQXldKSzVyPU[gcm0> NHLOOlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUS4NlkzQSd-MUW0PFI6Ojl:L3G+
CPT-K5 NFe1NGFkgXSxdH;4bYNqfHliYYPzZZk> NInoWYZ,OTBizszN MlfETWM2OD5zMDFOwG0> NGjrN5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUS4NlkzQSd-MUW0PFI6Ojl:L3G+
P388 MUPjfZRwfG:6aXPpeJkh[XO|YYm= MXn+NVAh|ryP NVPJVGRUUUN3ME2xOEBvVQ>? Mn74QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
P388/CPT45 MUDjfZRwfG:6aXPpeJkh[XO|YYm= NV;DV4hohjFyIN88US=> M4[1cmlEPTB-MUCg{txO NVzOWXByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
KB3-1 MojpZ5l1d3SxeHnjbZR6KGG|c3H5 NX3UTG82hjFyIN88US=> MVTJR|UxRTRyIH7N NU\CXXdsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
KBV-1 + MDR1 NXHmflNt[3m2b4TvfIlkcXS7IHHzd4F6 MWr+NVAh|ryP MmXhTWM2OD12NECgcm0> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
KBH NIPHTW1kgXSxdH;4bYNqfHliYYPzZZk> M371[54yOCEQvF2= NUjXTY9yUUN3ME20OFAhdk1? NI\FbVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUS4NlkzQSd-MUW0PFI6Ojl:L3G+
HOP-62 NHLoWIhkgXSxdH;4bYNqfHliYYPzZZk> NIHsW4N,OTBizszN MmjOS2k2OD1zMDDuUS=> NWLJSZBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPjRpPkG1OVA6OTZ2PD;hQi=>
HCT-116 M17Wd4N6fG:2b4jpZ4l1gSCjc4PhfS=> Mon1glExKM7:TR?= M2qwWGdKPTB;M{Cgcm0> M2Tk[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
F-539 NHG5cFNkgXSxdH;4bYNqfHliYYPzZZk> MYH+NVAh|ryP MkjoS2k2OD1zMDDuUS=> NIPGRZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
UACC-62 MnfxZ5l1d3SxeHnjbZR6KGG|c3H5 NWnudppMhjFyIN88US=> NYXxXYhFT0l3ME2xNEBvVQ>? M3vvdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
OVCAR-3 MVfjfZRwfG:6aXPpeJkh[XO|YYm= M1fhfZ4yOCEQvF2= NWTzeZV6T0l3ME2yNlAhdk1? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
SN12C NXPMZoFo[3m2b4TvfIlkcXS7IHHzd4F6 MUT+NVAh|ryP NWXjSFJqT0l3ME2yNEBvVQ>? NWrScpkzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPjRpPkG1OVA6OTZ2PD;hQi=>
DU-145 MkfoZ5l1d3SxeHnjbZR6KGG|c3H5 NH:2bWZ,OTBizszN M1zMVWdKPTB;MUCgcm0> NE\NNoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
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SKVLB NYfSS3ZS[3m2b4TvfIlkcXS7IHHzd4F6 M4q1W2lEPTB;NUOgcm0> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86ODB|NUKwK|46ODB|NUKwQE9iRg>?
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L1210 M37QVWZ2dmO2aX;uJIF{e2G7 Ml7NR49v[2WwdILheIlwdiC2aHH0JIlvcGmkaYTzJJRp\SCycn;sbYZmemG2aX;uJI9nKExzMkGwJINmdGy|IHL5JFUxLSxiSVO1NF0xNjBzNN88UU4> NFzsdJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO3OFI5Lz5{NUO3OFI5RC:jPh?=
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HL-60 NV\FVI11TnWwY4Tpc44h[XO|YYm= NHLHfpBKdmirYnn0bY9vKG:oIGTvdI9qe2:vZYLhd4UhUSCkeTDjcIVifmGpZTDjc41xdGW6IH\vdo1ifGmxbjDpckBpfW2jbjDIUE03OCClZXzsd{whUUN3ME2wMlY5|ryPLh?= NGnYVpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEGwPVgyLz56NEGwPVgyRC:jPh?=
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MDA-MB-435 MlfmSpVv[3Srb36gZZN{[Xl? NHzGW5NKdmirYnn0bY9vKGGpYXnud5QhVUSDLV3CMVQ{PSCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{KGmwIITo[UBi[nOnbnPlJI9nKEiVQTygTWM2OD1yLkCxOe69VS5? Mn\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyNUK4NFIoRjFzMEWyPFAzRC:jPh?=
MDA-MB-435 MlG5SpVv[3Srb36gZZN{[Xl? NVjEV5c2UW6qaXLpeIlwdiCjZ3HpcpN1KE2GQT3NRk01OzViaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyCrbjD0bIUheHKnc3XuZ4Uhd2ZiMUGgcYcwdUxiSGPBMEBKSzVyPUCuN|c2|ryPLh?= NF3ZZos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUC1NlgxOid-MUGwOVI5ODJ:L3G+
Jurkat NIjWVZhHfW6ldHnvckBie3OjeR?= NIPle5NKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUnW{a3H0JIh2dWGwIHzleYtmdWmjIHPlcIx{NCCLQ{WwQVAvODB3Nt88UU4> Ml;mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|OESyOFUoRjFzM{i0NlQ2RC:jPh?=
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Lewis lung carcinoma cells MYHGeY5kfGmxbjDhd5NigQ>? MmXHTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGxmf2m|IHz1coch[2G{Y3nuc41iKGOnbHzzMEBKSzVyPUCuNFM{|ryPLh?= NVOzbGJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzPFQzPDVpPkGxN|g1OjR3PD;hQi=>
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HeLa NEP2R2pEgXSxdH;4bYNqfHliYYPzZZk> Mmf6OFghcHK| Mn\OR5l1d3SxeHnjbZR6KGGpYXnud5QheDV|LXTl[olkcWWwdDDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5{zszNMi=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdzNUOxPUc,OTl5MUWzNVk9N2F-
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K562 MkfKR5l1d3SxeHnjbZR6KGG|c3H5 MVK0PEBpenN? Mk[1R5l1d3SxeHnjbZR6KGGpYXnud5QheDV|LXTl[olkcWWwdDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OS52zszNMi=> MnXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MUWzNVkoRjF7N{G1N|E6RC:jPh?=
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Hep2 Mk[zR5l1d3SxeHnjbZR6KGG|c3H5 NX\IRlk4PzJiaILz MnfkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVxOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVMvODUQvF2u NVftfIloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlM{QDhpPkK4PVI{Ozh6PD;hQi=>
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A549 MkXiR5l1d3SxeHnjbZR6KGG|c3H5 NGnr[Ws4OiCqcoO= NXLWdItDS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVAvODB6NkROwG0v NEThbGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|c6OCd-Mki5Nlc4QTB:L3G+
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MDA-MB-231 NGjnZmdEgXSxdH;4bYNqfHliYYPzZZk> MkfwO|IhcHK| MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5|MEhOwG0v NU[zPFNRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc4QTBpPkK4PVI4PzlyPD;hQi=>
HL60 MkXERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWXxfYVXPzJiaILz NGDyNnBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IITyfZBp[W5iYnz1[UB{fGGrbnnu[{Bj[XOnZDDo[Y1ifG:leYTvcYV1emmlIH3leIhw\CxiSVO1NF0xNjl{zszNMi=> NXPlUoJ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|E3OTZpPkK5NVMyPjF4PD;hQi=>
PC3 M3PvXmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGnWeldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDifUBOXFRiYYPzZZktKEmFNUC9Ok46Ps7:TT6= NWr2e3h7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN|E3OTZpPkK5NVMyPjF4PD;hQi=>
HL60 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M1rvU|Q5KGi{cx?= NX7tdWZjS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IFHUVIxqfGVvYnHz[YQhdHWvaX7ld4NmdnRiYYPzZZktKEmFNUC9NE4xOs7:TT6= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
HL60 M4nw[mFxd3C2b4Ppd{Bie3OjeR?= M3zNTVI1KGi{cx?= MYTJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4F{eGG|ZTCzM|ch[WO2aY\peJkh[W[2ZYKgNlQhcHK|IHL5JINie3Cjc3Wt[4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCLQ{WwQVAvODgQvF2u NUHzbnhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNlMxQTlpPkK5NlI{ODl7PD;hQi=>
K562 NIniTndEgXSxdH;4bYNqfHliYYPzZZk> NHjyNII1QCCqcoO= NIrKOnpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliQWTQcIl1\S2kYYPl[EBtfW2rbnXzZ4VvfCCjc4PhfUwhUUN3ME2wMlA6|ryPLh?= NXPvcotZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNlMxQTlpPkK5NlI{ODl7PD;hQi=>
MCF7 M1\6dmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWe0PEBpenN? MVPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhSVSSbHn0[U1j[XOnZDDseY1qdmW|Y3XueEBie3OjeTygTWM2OD1yLkO0{txONg>? NX3se2NuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNlMxQTlpPkK5NlI{ODl7PD;hQi=>
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HCT116 NWHrXFZnTnWwY4Tpc44h[XO|YYm= NX61SHVHUW6qaXLpeIlwdiCxZjDEUmEhfG:yb3nzc41memG|ZTCxJIlvKEixbX:gd4FxcWWwczCobJVu[W5rIFjDWFEyPiClZXzsd{whUUN3ME20Mlc2|ryPLh?= NYnwUWdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
VACO 241 NX\odGI1TnWwY4Tpc44h[XO|YYm= MV\Jcohq[mm2aX;uJI9nKESQQTD0c5BwcXOxbXXyZZNmKDFiaX6gTI9udyC|YYDp[Y5{KCiqdX3hckkhXkGFTzCyOFEh[2WubIOsJGlEPTB;ND65Oe69VS5? M3\zOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
SAS Mlf3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MV:3NkBpenN? NU\heVVUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDTRXMh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTcQvF2u NX;UeopHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
MDA-MB-231 NHTEUHhEgXSxdH;4bYNqfHliYYPzZZk> Mo[1OFghcHK| Mmn6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF4LkS0{txONg>? MmjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
PC3 M3S5NGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3LaWlQ5KGi{cx?= MlHpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUiuNlTPxE1w M4XZZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
AGS M{fPeGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnzKO|IhcHK| MnznRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDR2OgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVI{Njd4zszNMi=> M4f2NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
MCF7 NY\1UIlMTnWwY4Tpc44h[XO|YYm= MmXKNVAhfU1? NGLKcJAyOiCqcoO= NELFSZZRd2m|b37pcoch[WO2aY\peJkh[XRidH;wc4l{d22ncnHz[UAyKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOTJiaILzJIJ6KGmvbYXuc4JidmRiZHXwcIV1cW:wIHHzd4F6 MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OU8oRkOqRV3CUFww[T5?
A549 MV3BdI9xfG:|aYOgZZN{[Xl? NHXDeo4yOiC2bzCxOUBpenN? MmX4TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIZwem2jdHnvckBw\iCjcH;weI91cWNiYn;kbYV{KGGodHXyJFEzKHSxIEG1JIhzeyCkeTDmcI94KGO7dH;t[ZRzcWNibXX0bI9l NEDhVpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
A549 MlTlRZBweHSxc3nzJIF{e2G7 MmDvNVIhfG9iMUWgbJJ{ NXXxTJVyUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygZ49v\GWwc3H0bY9vKGGodHXyJFEzKHSxIEG1JIhzeyCkeTDmcI94KGO7dH;t[ZRzcWNibXX0bI9l MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OU8oRkOqRV3CUFww[T5?
MDA-MB-231 MVTD[YxtKGO7Y3zlJIF{e2G7 Mom3NUB2VQ>? NWLIZ4VzOTZiaILz MWPD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDTMZBp[XOnIHH0JFEhfU1iaX7jeYJifGWmIH\vdkAyPiCqcoOgZpkh\myxdzDjfZRwdWW2com= NWjMTIk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin1 / CDK1 / CDK2 ; 

PubMed: 29963130     


Western blot analysis indicated that camptothecin (6 µM) downregulates the expression of cell-cycle-associated proteins, cyclin 1, CDK1 and CDK2 in NPC cells. β-actin was used as a loading control.

Vimentin / Fibronectin / E-cadherin ; 

PubMed: 29963130     


Western blot analysis revealed that camptothecin (6 µM) treatment downregulates the expression of vimentin and fibronectin, and upregulates the expression of E-cadherin in NPC cells. β-actin was used as a loading control. NPC, nasopharyngeal carcinoma.

TGF-β / PI3K / pPI3K / AKT / pAKT ; 

PubMed: 29963130     


Western blot analysis revealed that camptothecin (6 µM) treatment inhibits the expression of TGF-β, PI3K and AKT in NPC cells. 

p53 / Cleaved caspase-3 / Cleaved PARP ; 

PubMed: 17548347     


NPCs in trophic factor-containing media were treated with 10 μM camptothecin for 0, 2, 4, 6, or 8 h, and extracts were immunoblotted for p53, active cleaved caspase-3, cleaved PARP, and total GSK3α/β as a loading control.

29963130 17548347
In vivo Camptothecin (8 mg/kg) displays complete growth inhibition and regression in mice xenografts of various tumors, including colon, lung, breast, stomach, and ovary tumors. [3] In mice, combinations of Camptothecin (50 mg/kg) and TNF (5 and 7 μg/kg), but not Camptothecin alone, induces liver damage. [4]

Protocol

Kinase Assay:[2]
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Topoisomerase I Cleavable Complex Assay:

Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine
Cell Research:[2]
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  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 0.17 nM–10 mM
  • Incubation Time: 48 hours
  • Method: Tumor cells are plated in 100 μL of medium in 96-well microtiter plates at a density of 1500 to 4000 cells per well and allowed to adhere overnight. Cells are incubated with Camptothecin for 48 hours and then with fresh medium for 48 hours. Camptothecin at each concentration is added in quadruplicate. Following a 4-hour incubation of treated cells with MTT, the reduced dye product is extracted from the cells with 0.2 mL of DMSO followed by 50 μL of Sorensen's buffer. The plates are shaken briefly, and the absorbance at 570 nm is read and quantitated. Curves are fitted to the MTT assay data using a four-parameter logistic equation.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Nude mice (NIH-I high fertility strain) bearing xenografts of CASE, SW48, DOY, SPA, and CLO cells
  • Dosages: 0–8 mg/kg
  • Administration: Administered via i.m. or i.v. injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 3 mg/mL (8.61 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.35
Formula

C20H16N2O4

CAS No. 7689-03-4
Storage powder
in solvent
Synonyms CPT, Campathecin, (S)-(+)-Camptothecin
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00808184 Completed Drug: CPT-11 Raltegravir (Isentress®) Midazolam Solid Tumor National University Hospital Singapore April 2010 Phase 4
NCT01040312 Completed Drug: CPT-11|Drug: Platinum analogues Small Cell Lung Cancer|Non-small Cell Lung Cancer|Cervical Cancer|Ovarian Cancer|Gastric Cancer (Inoperable and Recurrent) Daiichi Sankyo Co. Ltd.|Daiichi Sankyo Inc. October 15 2009 --
NCT00617786 Completed Procedure: Current Perception Threshold (CPT) Testing Incontinence William Beaumont Hospitals October 2008 Not Applicable
NCT00947739 Completed Drug: Camptothecin-20-O-Propionate Hydrate (CZ48) Advanced Solid Tumors|Lymphomas New Mexico Cancer Care Alliance|Christus Stehlin Foundation for Cancer Research September 2008 Phase 1
NCT00734682 Completed Drug: Nanoliposomal CPT-11 Glioblastoma|Gliosarcoma|Anaplastic Astrocytoma|Anaplastic Oligodendroglioma University of California San Francisco August 2008 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID