Camptothecin (NSC-100880)

Catalog No.S1288 Synonyms: CPT, Campathecin, (S)-(+)-Camptothecin

For research use only.

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.

Camptothecin (NSC-100880) Chemical Structure

CAS No. 7689-03-4

Selleck's Camptothecin (NSC-100880) has been cited by 104 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Targets
Topo I [2]
(Cell-free assay)
0.68 μM
In vitro

Camptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin displays nanomolar potency in cytotoxicity against many human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB, with IC50 values ranging from 37 nM to 48 nM. [2] In combination with TNF, Camptothecin induces apoptosis in primary mouse hepatocytes, with an IC50 value of 13 μM. Camptothecin also abrogated the TNF-induced NF-κB Activation, as well as the expression of TNF-receptor associated factor 2 (TRAF2), X-linked inhibitor of apoptosis protein (X-IAP), and FLICE-inhibitory protein (FLIP). [4] In HCT116 cells, Camptothecin (5 μM) induces proteasome-mediated degradation of mixed lineage leukemia 5 (MLL5) protein, which leads to phosphorylation of p53 at Ser392. [5] Due to the low solubility and adverse effects of Camptothecin, various Camptothecin analogues have been developed, and two of them, topotecan and irinotecan, has been approved by FDA and are used in cancer chemotherapy.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 NXe5To5oT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MnPXTWM2OD1|MjDuUS=> NIrvWXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEO0Olk{Oyd-MUCzOFY6OzN:L3G+
P388CPT5 R MXrHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MX\JR|UxRTJwODFOwG0> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODN2NkmzN{c,OTB|NE[5N|M9N2F-
KBwt MUXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NY[0enB4UUN3ME20NEBvVQ>? NHe4eYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMESxNVQ4Pid-MUC0NVE1PzZ:L3G+
KBMDR NHPuSmtIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NUjuUnJ6UUN3ME23NEBvVQ>? M4rTWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNEGxOFc3Lz5zMESxNVQ4PjxxYU6=
KBV20C NGTYVo1Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NUHCT3hSUUN3ME2zNEBvVQ>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
KB7D MkLSS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFTlR2dKSzVyPUO1JI5O NWfOR5djRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KBCamp NGPueJpIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NXH1NVRvUUN3ME2xMlA1KM7:TR?= NXPad5o3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
HT29 M1y1N4N6fG:2b4jpZ4l1gSCjc4PhfS=> NFq1WIFKSzVyPUiwJI5O M1WwWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
A549 Mn;EZ5l1d3SxeHnjbZR6KGG|c3H5 MYrJR|UxRTZ5IH7N MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh2MUiwPEc,OTB6NEG4NFg9N2F-
T24 MnzFZ5l1d3SxeHnjbZR6KGG|c3H5 M320WGlEPTB;OEigcm0> M2TERlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
HOP-62 NVr4c3pPT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MULJR|UxRTFyIH7N NEjBSoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
HCT-116 MV7Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MoHJTWM2OD1|MDDuUS=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
SF-539 Mnn4S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MkXTTWM2OD1zMDDuUS=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
UACC-62 NU[1OI9qT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MnXHTWM2OD1zMDDuUS=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
OVCAR-3 NYK0U4d{T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NV\aWYdXUUN3ME2yNlAhdk1? NInuTYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
SN12C NHK4b|hIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1nLWmlEPTB;MkCgcm0> M4nMdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
DU-145 MlLOS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MlvaTWM2OD1zMDDuUS=> NF;sWG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
MDA-MB-435 MWfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFOwWJVKSzVyPUSwJI5O MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
WiDr M3\jN4N6fG:2b4jpZ4l1gSCjc4PhfS=> MYjEUXNQ M1TVNGlEPTB;MUegcm0> MlHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
A549 NFr2emhkgXSxdH;4bYNqfHliYYPzZZk> NELGT4RFVVOR M3LYOGlEPTB;MUSgcm0> M2naZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
MKN45 M{TwNIN6fG:2b4jpZ4l1gSCjc4PhfS=> NYGxO25KTE2VTx?= Mom5TWM2OD1zNzDuUS=> M{frZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
SK-OV-3 M1;qeoN6fG:2b4jpZ4l1gSCjc4PhfS=> Mlq2SG1UVw>? NHLUeXVKSzVyPUKwJI5O M{\TZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
H128 NWi2WoRV[3m2b4TvfIlkcXS7IHHzd4F6 NV7Gbog1TE2VTx?= MlOwTWM2OD1zODDuUS=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
SK-BR-3 MkSwZ5l1d3SxeHnjbZR6KGG|c3H5 NYrmWHlRTE2VTx?= MoHQTWM2OD1{MDDuUS=> Mlm4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
LX-1 NHX0N4pkgXSxdH;4bYNqfHliYYPzZZk> M4mweGROW09? MUfJR|UxRTF{MDDuUS=> MofnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF6NUi3N|coRjFzOEW4O|M4RC:jPh?=
HCT116 MmnaZ5l1d3SxeHnjbZR6KGG|c3H5 NUHGSXdLTE2VTx?= MoToTWM2OD17IH7N M1;aXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzOEW4O|M4Lz5zMUi1PFc{PzxxYU6=
A2780 M2fJXIN6fG:2b4jpZ4l1gSCjc4PhfS=> NH3Y[nVFVVOR NI\RToNKSzVyPUSgcm0> M2rqTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzOEW4O|M4Lz5zMUi1PFc{PzxxYU6=
IMR-32 NGTrVVhkgXSxdH;4bYNqfHliYYPzZZk> MVX+NVAh|ryP NIXIV2JFVVOR NHjqV|NKSzVyPUKuNlEhdk1? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZzN{i5OEc,OTJ4MUe4PVQ9N2F-
P388 MV7jfZRwfG:6aXPpeJkh[XO|YYm= NFPlSo9KSzVyPUGzJI5O Mn3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
Lewis NVTaNYRL[3m2b4TvfIlkcXS7IHHzd4F6 MoXwTWM2OD1|MzDuUS=> Mom5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
JLC NFrubGJkgXSxdH;4bYNqfHliYYPzZZk> MWDJR|UxRTVwNjDuUS=> NUX6UGJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2NlAxQDFpPkGyOlIxODhzPD;hQi=>
HT-29 NYfRWGFr[3m2b4TvfIlkcXS7IHHzd4F6 MlvCTWM2OD1zLkSg{txO NF30SHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[zPVU1OSd-MUK2N|k2PDF:L3G+
Caki-2 NVv5[IdC[3m2b4TvfIlkcXS7IHHzd4F6 MX;JR|UxRTNwOU[g{txO NHHOfow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[zPVU1OSd-MUK2N|k2PDF:L3G+
A549 M1HB[IN6fG:2b4jpZ4l1gSCjc4PhfS=> NVnk[|JwUUN3ME2yMlU{KM7:TR?= M{SzdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO5OVQyLz5zMk[zPVU1OTxxYU6=
HEC-1-B M1HNfYN6fG:2b4jpZ4l1gSCjc4PhfS=> MnH6TWM2OD16Lk[0JO69VQ>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
HL-60 MV;jfZRwfG:6aXPpeJkh[XO|YYm= MVLJR|UxRTZ4IH7N M{PuTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO5OVQyLz5zMk[zPVU1OTxxYU6=
Col2 M3rReIN6fG:2b4jpZ4l1gSCjc4PhfS=> NYfYR|B{hjFizszN NGiwSW5GTDVyPUW3JI5O MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
HUVEC NXflboFJ[3m2b4TvfIlkcXS7IHHzd4F6 MXT+NUDPxE1? MV;FSFUxRTJ3ODDuUS=> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
KB NYrTNI05[3m2b4TvfIlkcXS7IHHzd4F6 MojYglEh|ryP NHvh[GlGTDVyPUKyJI5O M2jFUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
LCNaP NEnXOIlkgXSxdH;4bYNqfHliYYPzZZk> MlqzglEh|ryP MYjFSFUxRTJ6IH7N M1Xu[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
Lu1 MWTjfZRwfG:6aXPpeJkh[XO|YYm= MY\+NUDPxE1? Mkj1SWQ2OD1{OTDuUS=> M3fXb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
RPMI8402 NXfqSW92[3m2b4TvfIlkcXS7IHHzd4F6 Mn6yglExKM7:TR?= NFWwNlJKSzVyPU[gcm0> NX3IOItORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
CPT-K5 Ml7wZ5l1d3SxeHnjbZR6KGG|c3H5 M3jIUp4yOCEQvF2= NUjGS2g3UUN3ME6xNEDPxE1? NVnNc25rRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
P388 M3r3VYN6fG:2b4jpZ4l1gSCjc4PhfS=> MkWyglExKM7:TR?= M3vuRmlEPTB;MUSgcm0> NVrCc4xHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
P388/CPT45 NFGwR|RkgXSxdH;4bYNqfHliYYPzZZk> NEPjfo1,OTBizszN Mkf0TWM2OD5zMDFOwG0> M1XxNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
KB3-1 MX\jfZRwfG:6aXPpeJkh[XO|YYm= NHLTNpR,OTBizszN MnjhTWM2OD12MDDuUS=> NW[2S5Q3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
KBV-1 + MDR1 MVPjfZRwfG:6aXPpeJkh[XO|YYm= NFT0WIh,OTBizszN MonCTWM2OD12NECgcm0> M2TKZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
KBH MUDjfZRwfG:6aXPpeJkh[XO|YYm= MmS5glExKM7:TR?= MnTWTWM2OD12NECgcm0> NYLGPXczRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW0PFI6OjlpPkG1OFgzQTJ7PD;hQi=>
HOP-62 NWHZS|NG[3m2b4TvfIlkcXS7IHHzd4F6 NVPZTGQxhjFyIN88US=> NHvVcG5IUTVyPUGwJI5O NHjKTXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
HCT-116 MYnjfZRwfG:6aXPpeJkh[XO|YYm= M3m5XZ4yOCEQvF2= Mly1S2k2OD1|MDDuUS=> NYfqSJBbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPjRpPkG1OVA6OTZ2PD;hQi=>
F-539 M1HjeIN6fG:2b4jpZ4l1gSCjc4PhfS=> NVjqZWlThjFyIN88US=> NVzoemE4T0l3ME2xNEBvVQ>? NEXTR3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
UACC-62 MlLGZ5l1d3SxeHnjbZR6KGG|c3H5 MXn+NVAh|ryP Mnm5S2k2OD1zMDDuUS=> M1XsPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
OVCAR-3 NWXSfYVw[3m2b4TvfIlkcXS7IHHzd4F6 MmLZglExKM7:TR?= NIfxRWJIUTVyPUKyNEBvVQ>? M136cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
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DU-145 M4Pk[4N6fG:2b4jpZ4l1gSCjc4PhfS=> NVP1NotNhjFyIN88US=> MX3HTVUxRTFyIH7N NXTK[IJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPjRpPkG1OVA6OTZ2PD;hQi=>
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OVCAR-3 NF3LdFNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3LxPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iT2\DRXIuOyClZXzsd{whT0l3ME2wMlIz|ryPLh?= NWnKcpEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2N|A5QTFpPkG4OlMxQDlzPD;hQi=>
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RPMI8402 M37F[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MkPjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnBOUTh2MEKgZ4VtdHNiYX\0[ZIhVVSWIHHzd4F6NCCLQ{WwQVAvODB4zszNMi=> NImy[3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEiyPVM{PCd-MUi4Nlk{OzR:L3G+
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A549 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MYm3NkBpenN? NY\teYhRS3m2b4TvfIlkcXS7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;OD64O:69VS5? M4fVN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUKzN|gzLz5{OEmyN|M5OjxxYU6=
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MCF7 M3roOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlLBO|IhcHK| MVPDfZRwfG:6aXPpeJkhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOy54Mt88UU4> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{M{O4Nkc,Ojh7MkOzPFI9N2F-
TE32 M1W0SWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUmxOZN5PzJiaILz NH;zb3REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVTTN{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OS5{NN88UU4> NVLC[G56RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlM{QDhpPkK4PVI{Ozh6PD;hQi=>
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HCT116 MlzNR5l1d3SxeHnjbZR6KGG|c3H5 MlnmO|IhcHK| MoHJR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OS56ON88UU4> Ml3LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7MkOzPFgoRjJ6OUKzN|g5RC:jPh?=
Hep2 M1XsdGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlXnO|IhcHK| NIC0bpFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XB{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Oy5yNN88UU4> NIXHZmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|M5QCd-Mki5NlM{QDh:L3G+
A549 NYjhU5F[S3m2b4TvfIlkcXS7IHHzd4F6 Ml60O|IhcHK| Mm\sR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVUvQTQQvF2u NWnwWIFqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlM{QDhpPkK4PVI{Ozh6PD;hQi=>
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KBVIN NXTPS25MS3m2b4TvfIlkcXS7IHHzd4F6 M{PQclczKGi{cx?= NV;tUJJwS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0KYSV6gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0xNjBzNUhOwG0v MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{e5NEc,Ojh7Mke3PVA9N2F-
KB MoXsR5l1d3SxeHnjbZR6KGG|c3H5 MUS3NkBpenN? Mn\rR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1yLkC1{txONg>? MoKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mke3PVAoRjJ6OUK3O|kxRC:jPh?=
MCF7 MnXmR5l1d3SxeHnjbZR6KGG|c3H5 NVnsbIZMPzJiaILz MmTvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFg4Pc7:TT6= M2LP[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3O|kxLz5{OEmyO|c6ODxxYU6=
MDA-MB-231 M1fMNmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nZd|czKGi{cx?= NHjTPWpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTB;MD6zNFfPxE1w Mn[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7Mke3PVAoRjJ6OUK3O|kxRC:jPh?=
HL60 M{\NcmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnzzO|IhcHK| MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KHS{eYDoZY4h[my3ZTDzeIFqdmmwZzDiZZNm\CCqZX3heI9kgXSxbXX0dolkKG2ndHjv[EwhUUN3ME2wMlkz|ryPLh?= M3TkZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUOxOlE3Lz5{OUGzNVYyPjxxYU6=
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HL60 M37EN2Fxd3C2b4Ppd{Bie3OjeR?= MWmyOEBpenN? NGXmUGFKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFjMOlAh[2WubIOgZZN{\XO|ZXSgZZMh[2G|cHHz[UA{NzdiYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KGOjc4Dhd4Uu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDJR|UxRTBwMEhOwG0v NXy0cWt1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyNlMxQTlpPkK5NlI{ODl7PD;hQi=>
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PC3 MnjXR5l1d3SxeHnjbZR6KGG|c3H5 NEHDTJo1QCCqcoO= NFTTSWtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCDVGDsbZRmNWKjc3XkJIx2dWmwZYPj[Y51KGG|c3H5MEBKSzVyPUCuOO69VS5? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
HepG2 M2OxW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUW0PEBpenN? M4Cyd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliQWTQcIl1\S2kYYPl[EBtfW2rbnXzZ4VvfCCjc4PhfUwhUUN3ME2wMlQ{|ryPLh?= M{K3blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MkKzNFk6Lz5{OUKyN|A6QTxxYU6=
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HepG2 M1nqfmFxd3C2b4Ppd{Bie3OjeR?= NV3NU|l4OjRiaILz NXTN[lVrUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyClYYPwZZNmKDNxNzDhZ5Rqfmm2eTDh[pRmeiB{NDDodpMh[nliY3HzdIF{\S2pbH:gcJVucW6nc3PlcpQh[XO|YYmsJGlEPTB;ND6zO:69VS5? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
RPE1 NFm0XGNCeG:ydH;zbZMh[XO|YYm= NULUVnJ{OjRiaILz NGTrcIFKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIGLQSVEh[2WubIOgZZN{\XO|ZXSgZZMh[2G|cHHz[UA{NzdiYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KGOjc4Dhd4Uu\2yxIHz1cYlv\XOlZX70JIF{e2G7LDDJR|UxRTJ5LkNOwG0v MoXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{MkOwPVkoRjJ7MkKzNFk6RC:jPh?=
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MDA-MB-231 M2fkUmN6fG:2b4jpZ4l1gSCjc4PhfS=> NI[wUoQ1QCCqcoO= MlrhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF4LkS0{txONg>? NY\YO5RVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
PC3 MlfVR5l1d3SxeHnjbZR6KGG|c3H5 M4P6OFQ5KGi{cx?= MmraR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUiuNlTPxE1w M{m1fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
AGS NFfyeItCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{TafVczKGi{cx?= NVvDUVNWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBS3Mh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTJ|Lke2{txONg>? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OU8oRkOqRV3CUFww[T5?
MCF7 MmjJSpVv[3Srb36gZZN{[Xl? NGTuRXIyOCC3TR?= NEmy[ZEyOiCqcoO= MnflVI9qe2:waX7nJIFkfGm4aYT5JIF1KHSxcH;pd49u\XKjc3WgNUBqdiCqdX3hckBOS0Z5IHPlcIx{KGG2IEGwJJVOKGGodHXyJFEzKGi{czDifUBqdW23bn;iZY5lKGSncHzleIlwdiCjc4PhfS=> NX3XR4t7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
A549 NUXFbnZ[SXCxcITvd4l{KGG|c3H5 MnO3NVIhfG9iMUWgbJJ{ MXnJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOg[o9zdWG2aX;uJI9nKGGyb4D0c5Rq[yCkb3Tp[ZMh[W[2ZYKgNVIhfG9iMUWgbJJ{KGK7IH\sc5ch[3m2b33leJJq[yCvZYToc4Q> NEXSTGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
A549 Mn2yRZBweHSxc3nzJIF{e2G7 M4LHNVEzKHSxIEG1JIhzew>? MmX0TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJINmdGxiY3;u[IVve2G2aX;uJIFnfGW{IEGyJJRwKDF3IHjyd{BjgSCobH;3JIN6fG:vZYTybYMhdWW2aH;k NXHh[ohtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
MDA-MB-231 Mlm1R4VtdCCleXPs[UBie3OjeR?= NVfES|FvOSC3TR?= M4HOeFE3KGi{cx?= NW[1TJd3S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhWy2yaHHz[UBifCBzIIXNJIlv[3WkYYTl[EBnd3JiMU[gbJJ{KGK7IH\sc5ch[3m2b33leJJ6 M1zkVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
Assay
Methods Test Index PMID
Western blot Cyclin1 / CDK1 / CDK2 ; Vimentin / Fibronectin / E-cadherin ; TGF-β / PI3K / pPI3K / AKT / pAKT ; p53 / Cleaved caspase-3 / Cleaved PARP 29963130 17548347
In vivo Camptothecin (8 mg/kg) displays complete growth inhibition and regression in mice xenografts of various tumors, including colon, lung, breast, stomach, and ovary tumors. [3] In mice, combinations of Camptothecin (50 mg/kg) and TNF (5 and 7 μg/kg), but not Camptothecin alone, induces liver damage. [4]

Protocol (from reference)

Kinase Assay:[2]
  • Topoisomerase I Cleavable Complex Assay:

    Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine

Cell Research:[2]
  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 0.17 nM–10 mM
  • Incubation Time: 48 hours
  • Method: Tumor cells are plated in 100 μL of medium in 96-well microtiter plates at a density of 1500 to 4000 cells per well and allowed to adhere overnight. Cells are incubated with Camptothecin for 48 hours and then with fresh medium for 48 hours. Camptothecin at each concentration is added in quadruplicate. Following a 4-hour incubation of treated cells with MTT, the reduced dye product is extracted from the cells with 0.2 mL of DMSO followed by 50 μL of Sorensen's buffer. The plates are shaken briefly, and the absorbance at 570 nm is read and quantitated. Curves are fitted to the MTT assay data using a four-parameter logistic equation.
Animal Research:[3]
  • Animal Models: Nude mice (NIH-I high fertility strain) bearing xenografts of CASE, SW48, DOY, SPA, and CLO cells
  • Dosages: 0–8 mg/kg
  • Administration: Administered via i.m. or i.v. injection

Solubility (25°C)

In vitro

DMSO 3 mg/mL
(8.61 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 348.35
Formula

C20H16N2O4

CAS No. 7689-03-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04419272 Not yet recruiting Drug: Methylphenidate|Other: Placebo Epilepsy VA New York Harbor Healthcare System|Portland VA Medical Center|Miami VA Healthcare System April 2022 Phase 4
NCT04873583 Recruiting Drug: Methylprednisolone|Drug: Prednisolone Pediatric ALL University Hospital Inselspital Berne|University of Bern February 2022 Phase 3
NCT05000905 Not yet recruiting Behavioral: Adaptive Attention Training Pediatric Cancer University of California San Francisco January 1 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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