Camptothecin (NSC-100880)

For research use only.

Catalog No.S1288 Synonyms: CPT, Campathecin, (S)-(+)-Camptothecin

80 publications

Camptothecin (NSC-100880) Chemical Structure

CAS No. 7689-03-4

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.

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Selleck's Camptothecin (NSC-100880) has been cited by 80 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Targets
Topo I [2]
(Cell-free assay)
0.68 μM
In vitro

Camptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin displays nanomolar potency in cytotoxicity against many human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB, with IC50 values ranging from 37 nM to 48 nM. [2] In combination with TNF, Camptothecin induces apoptosis in primary mouse hepatocytes, with an IC50 value of 13 μM. Camptothecin also abrogated the TNF-induced NF-κB Activation, as well as the expression of TNF-receptor associated factor 2 (TRAF2), X-linked inhibitor of apoptosis protein (X-IAP), and FLICE-inhibitory protein (FLIP). [4] In HCT116 cells, Camptothecin (5 μM) induces proteasome-mediated degradation of mixed lineage leukemia 5 (MLL5) protein, which leads to phosphorylation of p53 at Ser392. [5] Due to the low solubility and adverse effects of Camptothecin, various Camptothecin analogues have been developed, and two of them, topotecan and irinotecan, has been approved by FDA and are used in cancer chemotherapy.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 NEDxOpBIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NIfxU2pKSzVyPUOyJI5O MlL5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB|NE[5N|MoRjFyM{S2PVM{RC:jPh?=
P388CPT5 R MXHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MWDJR|UxRTJwODFOwG0> M4L0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{S2PVM{Lz5zMEO0Olk{OzxxYU6=
KBwt Mn\NS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M3\w[2lEPTB;NECgcm0> MoTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB2MUG0O|YoRjFyNEGxOFc3RC:jPh?=
KBMDR MV3Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M3;EN2lEPTB;N{Cgcm0> NGjp[m49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMESxNVQ4Pid-MUC0NVE1PzZ:L3G+
KBV20C Mn;sS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NX;VfVJXUUN3ME2zNEBvVQ>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
KB7D M1\TR2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NEf2Z|RKSzVyPUO1JI5O NWjyXXhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
KBCamp MnfjS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWXiR5p7UUN3ME2xMlA1KM7:TR?= NW[2No92RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0NVE1PzZpPkGwOFEyPDd4PD;hQi=>
HT29 NYTMcVZk[3m2b4TvfIlkcXS7IHHzd4F6 M4HVTWlEPTB;OECgcm0> M4rMcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
A549 MnTEZ5l1d3SxeHnjbZR6KGG|c3H5 MVjJR|UxRTZ5IH7N NVvXVmI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC4OFE5ODhpPkGwPFQyQDB6PD;hQi=>
T24 Mnm0Z5l1d3SxeHnjbZR6KGG|c3H5 MYPJR|UxRTh6IH7N M{fjO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
HOP-62 MXfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M1nMZmlEPTB;MUCgcm0> NGP1Zmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
HCT-116 NXi1V5VKT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MV\JR|UxRTNyIH7N M2XHd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
SF-539 M2nvXWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MXrJR|UxRTFyIH7N M3;SXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
UACC-62 NYTkTpd{T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= Ml;GTWM2OD1zMDDuUS=> NVPVSHF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDNpPkGxNFIxOjh|PD;hQi=>
OVCAR-3 MnS2S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M{TBRWlEPTB;MkKwJI5O NGX2dW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
SN12C NIf0W4hIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MXLJR|UxRTJyIH7N NVv0OWc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDNpPkGxNFIxOjh|PD;hQi=>
DU-145 MVzHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NVTzNGZvUUN3ME2xNEBvVQ>? MmnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
MDA-MB-435 MVzHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NHfE[odKSzVyPUSwJI5O MkO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
WiDr NWPvVnhw[3m2b4TvfIlkcXS7IHHzd4F6 M3\kbmROW09? Mn:3TWM2OD1zNzDuUS=> NYrGNW1kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjlpPkGxN|M1PTZ7PD;hQi=>
A549 MmTpZ5l1d3SxeHnjbZR6KGG|c3H5 Ml3GSG1UVw>? MU\JR|UxRTF2IH7N MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
MKN45 MXnjfZRwfG:6aXPpeJkh[XO|YYm= NXvTNm1CTE2VTx?= MXjJR|UxRTF5IH7N NVK5N5FTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjlpPkGxN|M1PTZ7PD;hQi=>
SK-OV-3 M4XCcYN6fG:2b4jpZ4l1gSCjc4PhfS=> NF;KTHpFVVOR NHPNWHpKSzVyPUKwJI5O MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
H128 M3LydYN6fG:2b4jpZ4l1gSCjc4PhfS=> NH7PTJVFVVOR NIPENHpKSzVyPUG4JI5O MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
SK-BR-3 NXftcopZ[3m2b4TvfIlkcXS7IHHzd4F6 Mn7KSG1UVw>? NF7G[25KSzVyPUKwJI5O MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
LX-1 Ml\MZ5l1d3SxeHnjbZR6KGG|c3H5 NY\uOINxTE2VTx?= MVzJR|UxRTF{MDDuUS=> M17GRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzOEW4O|M4Lz5zMUi1PFc{PzxxYU6=
HCT116 M2Dhb4N6fG:2b4jpZ4l1gSCjc4PhfS=> NYHibWVxTE2VTx?= NH;JU3BKSzVyPUmgcm0> Mn\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF6NUi3N|coRjFzOEW4O|M4RC:jPh?=
A2780 NHSzcndkgXSxdH;4bYNqfHliYYPzZZk> NVzi[XZsTE2VTx?= MWHJR|UxRTRibl2= NHvUcVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUi1PFc{Pyd-MUG4OVg4Ozd:L3G+
IMR-32 NGLXO3VkgXSxdH;4bYNqfHliYYPzZZk> MUD+NVAh|ryP MlvsSG1UVw>? MV;JR|UxRTJwMkGgcm0> NVXBc5F5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2NVc5QTRpPkGyOlE4QDl2PD;hQi=>
P388 NIPPSo9kgXSxdH;4bYNqfHliYYPzZZk> M2XBVGlEPTB;MUOgcm0> MorOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
Lewis NUTPSnFY[3m2b4TvfIlkcXS7IHHzd4F6 MYDJR|UxRTN|IH7N NVr3VXJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2NlAxQDFpPkGyOlIxODhzPD;hQi=>
JLC MoXuZ5l1d3SxeHnjbZR6KGG|c3H5 MXXJR|UxRTVwNjDuUS=> MofXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
HT-29 NX\wbVVr[3m2b4TvfIlkcXS7IHHzd4F6 Mnv6TWM2OD1zLkSg{txO Mn;BQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4M{m1OFEoRjF{NkO5OVQyRC:jPh?=
Caki-2 NWLpXYw1[3m2b4TvfIlkcXS7IHHzd4F6 MVPJR|UxRTNwOU[g{txO M33IUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO5OVQyLz5zMk[zPVU1OTxxYU6=
A549 MULjfZRwfG:6aXPpeJkh[XO|YYm= MYrJR|UxRTJwNUOg{txO NVLr[|NLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
HEC-1-B NX:yT3V[[3m2b4TvfIlkcXS7IHHzd4F6 MnzJTWM2OD16Lk[0JO69VQ>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
HL-60 M4XsN4N6fG:2b4jpZ4l1gSCjc4PhfS=> NHLRdlVKSzVyPU[2JI5O M2LqOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO5OVQyLz5zMk[zPVU1OTxxYU6=
Col2 NUXKR244[3m2b4TvfIlkcXS7IHHzd4F6 MkPuglEh|ryP MWHFSFUxRTV5IH7N MlW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
HUVEC M1vMeoN6fG:2b4jpZ4l1gSCjc4PhfS=> M2i3W54yKM7:TR?= NUXwZYhuTUR3ME2yOVghdk1? MoWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
KB M1XKcIN6fG:2b4jpZ4l1gSCjc4PhfS=> M1K4TJ4yKM7:TR?= MUXFSFUxRTJ{IH7N MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
LCNaP NV;RPWhx[3m2b4TvfIlkcXS7IHHzd4F6 NV3GeFIyhjFizszN NGXLXWVGTDVyPUK4JI5O MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
Lu1 NFLQU3RkgXSxdH;4bYNqfHliYYPzZZk> NYXVblhChjFizszN M1znfGVFPTB;Mkmgcm0> MoSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
RPMI8402 MWHjfZRwfG:6aXPpeJkh[XO|YYm= M3SyR54yOCEQvF2= Mof2TWM2OD14IH7N MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
CPT-K5 NWHDNpBw[3m2b4TvfIlkcXS7IHHzd4F6 MmDNglExKM7:TR?= M171UmlEPTB-MUCg{txO MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
P388 NHrJd41kgXSxdH;4bYNqfHliYYPzZZk> MYD+NVAh|ryP NXuyWmFlUUN3ME2xOEBvVQ>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
P388/CPT45 M4jwVoN6fG:2b4jpZ4l1gSCjc4PhfS=> NIrEW49,OTBizszN MWLJR|UxRjFyIN88US=> MkfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
KB3-1 M3fLZ4N6fG:2b4jpZ4l1gSCjc4PhfS=> Mo[1glExKM7:TR?= M4rFWGlEPTB;NECgcm0> MmDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
KBV-1 + MDR1 Mn;nZ5l1d3SxeHnjbZR6KGG|c3H5 NGjLRZB,OTBizszN M2DLd2lEPTB;NESwJI5O M4XMSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
KBH NWXEe5RY[3m2b4TvfIlkcXS7IHHzd4F6 MUL+NVAh|ryP MlLyTWM2OD12NECgcm0> M{[0O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
HOP-62 M1nYXYN6fG:2b4jpZ4l1gSCjc4PhfS=> NWjyOWFHhjFyIN88US=> M4nvWWdKPTB;MUCgcm0> NVq0OplIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1NFkyPjRpPkG1OVA6OTZ2PD;hQi=>
HCT-116 NGfaWZVkgXSxdH;4bYNqfHliYYPzZZk> NYflWo1QhjFyIN88US=> MYfHTVUxRTNyIH7N NHWzNmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUWwPVE3PCd-MUW1NFkyPjR:L3G+
F-539 NFPCfmdkgXSxdH;4bYNqfHliYYPzZZk> Mk\oglExKM7:TR?= M{i4PGdKPTB;MUCgcm0> M3XEXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
UACC-62 Mme1Z5l1d3SxeHnjbZR6KGG|c3H5 NXzifYZlhjFyIN88US=> M3rSemdKPTB;MUCgcm0> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
OVCAR-3 M2Dx[oN6fG:2b4jpZ4l1gSCjc4PhfS=> MVv+NVAh|ryP MkHVS2k2OD1{MkCgcm0> MlPBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxOlQoRjF3NUC5NVY1RC:jPh?=
SN12C MojlZ5l1d3SxeHnjbZR6KGG|c3H5 NVf2c5VkhjFyIN88US=> MUTHTVUxRTJyIH7N MoHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3MEmxOlQoRjF3NUC5NVY1RC:jPh?=
DU-145 Mn;0Z5l1d3SxeHnjbZR6KGG|c3H5 NYf2cIZ1hjFyIN88US=> M2L1fWdKPTB;MUCgcm0> M1f4dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
MDA-MB-435 M1i0OIN6fG:2b4jpZ4l1gSCjc4PhfS=> MkiyglExKM7:TR?= NIH6OGlIUTVyPUSwJI5O MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
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SK-MEL-28b MX7jfZRwfG:6aXPpeJkh[XO|YYm= NVSwR49sUUN3ME20NEBvVQ>? M1XWfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkW0OlY6Lz5zN{K1OFY3QTxxYU6=
MCF-7 MX3jfZRwfG:6aXPpeJkh[XO|YYm= NGm0N5lKSzVyPUSwJI5O MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ3NE[2PUc,OTd{NUS2Olk9N2F-
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HepG2 M3rxeoN6fG:2b4jpZ4l1gSCjc4PhfS=> M4nTfmlEPTB;M{Cgcm0> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ3NE[2PUc,OTd{NUS2Olk9N2F-
DU145 M4fKSIN6fG:2b4jpZ4l1gSCjc4PhfS=> NXrNNZdFUUN3ME2xNEBvVQ>? M2ftTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkW0OlY6Lz5zN{K1OFY3QTxxYU6=
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SKVLB NU\abZlZ[3m2b4TvfIlkcXS7IHHzd4F6 M3nzN2lEPTB;NUOgcm0> NWPxZpNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUCwN|UzOCd-OUCwN|UzODxxYU6=
HT29 M3XMXYN6fG:2b4jpZ4l1gSCjc4PhfS=> MXfJR|UxRTh5Lkigcm0> NVTVS4x5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUCwN|UzOCd-OUCwN|UzODxxYU6=
KB NFXEc4VkgXSxdH;4bYNqfHliYYPzZZk> MVHJR|UxRThibl2= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86ODB|NUKwK|46ODB|NUKwQE9iRg>?
A427 MWfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NIDUbXl,OSEQvF2= MmXYSG1UVw>? MnOzTWM2OD1{NDDuUS=> NH[zWJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEe2NVEyLz57OEe2NVEyRC:jPh?=
PC-3 Mn:1S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NI\YOo5,OSEQvF2= MmL4SG1UVw>? MX\JR|UxRTV5IH7N M2XTfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{[xNVEoRjl6N{[xNVE9N2F-
K562adr MYDHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MUf+NUDPxE1? M3XpfWROW09? NVj5fZdJUUN3ME21O{BvVQ>? NVjSb3FPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3OlEyOSd-OUi3OlEyOTxxYU6=
MCF7mdr M3S4b2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MljVglEh|ryP NF74UoVFVVOR MXLJR|UxRTNwMTDuUS=> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDd4MUGxK|46QDd4MUGxQE9iRg>?
L1210 MWTGeY5kfGmxbjDhd5NigQ>? M{LwUGNwdmOnboTyZZRqd25idHjheEBqdmirYnn0d{B1cGVicILvcIln\XKjdHnvckBw\iCOMUKxNEBk\WyuczDifUA2OCVuIFnDOVA:OC5yMUVOwG0v MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN5NEK4K|4zPTN5NEK4QE9iRg>?
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HT-29 NXvxZ2VDS3m2b4TvfIlkcXS7IHHzd4F6 M{XMV2N6fG:2b4jpZ4l1gSC5YYOg[IV1\XKvaX7l[EBqdiC4aYTyc{BqdiCKVD2yPUBk\Wyuczjjc4xwdilib3[gbJVu[W5idIXtc5Ih[2WubDDsbY5meyCkeTD1d4lv\yCPVGSgZZN{[XluIFnDOVA:OC5yNEdOwG0v MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QDV|M{OxK|44QDV|M{OxQE9iRg>?
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L1210 NY\GWmxES3m2b4TvfIlkcXS7IHHzd4F6 NVjZVoRVS3m2b4TvfIlkcXS7IIfhd{Bu\WG|dYLl[EBwdiCldXz0eZJm\CCvdYLpcoUhdHmvcHjvZoxie3SrYzDs[ZVs\W2rYTDj[YxteyBqTEGyNVAqNCCLQ{WwQVAvODF3zszNMi=> NUjhcopURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEK0OlI{QCd-OEK0OlI{QDxxYU6=
HL-60 MlyxSpVv[3Srb36gZZN{[Xl? Mn7sTY5pcWKrdHnvckBw\iCWb4DvbZNwdWW{YYPlJGkh[nliY3zlZZZi\2ViY3;tdIxmgCCob4LtZZRqd25iaX6gbJVu[W5iSFytOlAh[2WubIOsJGlEPTB;MD62PO69VS5? NHzlT4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96NEGwPVgyLz56NEGwPVgyRC:jPh?=
KB MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;n[m8xS2:vcH;1coQh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{Bz\WS3Y3WgeIhmKGW6cH;u[Y51cWGuIHfyc5d1cCCxZjDLRkBk\WyuczDifUA2OCVuIFPDOVA:OC5yMEdOwG0v MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTd4N{[zNkc,QTd4N{[zNlww[T5?
MT-4 NUe4N25QT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkTqR49ueG:3bnSgZ49v[2WwdILheIlwdiC{ZYH1bZJm\CC2bzDy[YR2[2VidHjlJIV5eG:wZX70bYFtKGe{b4f0bEBw\iCPVD20JINmdGy|IHL5JFUxLSxiQ1O1NF0xNjBzzszNMi=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PzZ5NkOyK|46PzZ5NkOyQE9iRg>?
COLO 205 M1LUXWN6fG:2b4jpZ4l1gSCjc4PhfS=> NI\u[HBEgXSxdH;4bYNqfHliZYjwdoV{e2WmIHHzJJRp\SClb37j[Y51emG2aX;uJJRp[XRiaX7obYJqfGWmIHnuZ49zeG:{YYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdnSxIHPlcIx2dGG{IFTORUBw\iCqdX3hckBkd2yxcnXjeIFtKGOnbHzzJEhEV0yRIEKwOUktKEmFNUC9NE4xODV2zszNMi=> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODR5OUK5N{c,OTB2N{myPVM9N2F-
HepG2 M2j3OWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWXDfZRwfG:6aXPpeJkh\XiycnXzd4VlKGG|IITo[UBkd26lZX70doF1cW:wIIToZZQhcW6qaXLpeIVlKGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKGOnbHz1cIFzKESQQTDv[kBpfW2jbjDo[ZBifG:lZXzseYxieiClZXzsd{ApUGWyR{KpMEBKSzVyPUCuNFA3O87:TT6= M3ewblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNEe5Nlk{Lz5zMES3PVI6OzxxYU6=
H928 NUjVN4hWS3m2b4TvfIlkcXS7IHHzd4F6 M{PHT2N6fG:2b4jpZ4l1gSCneIDy[ZN{\WRiYYOgeIhmKGOxbnPlcpRz[XSrb36geIhifCCrbnjpZol1\WRiaX7jc5Jxd3KjdHnvckBw\iCdM1jdMZRpgW2rZHnu[UBqdnSxIHPlcIx2dGG{IFTORUBw\iCqdX3hckBtfW6pIHPhdoNqdm:vYTDj[YxteyBqSEmyPEktKEmFNUC9NE4xODd6zszNMi=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODR5OUK5N{c,OTB2N{myPVM9N2F-
CaSki M2fITmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2TCbWN6fG:2b4jpZ4l1gSCneIDy[ZN{\WRiYYOgeIhmKGOxbnPlcpRz[XSrb36geIhifCCrbnjpZol1\WRiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iY3XscJVt[XJiRF7BJI9nKGi3bXHuJINmen[rY3HsJINmdGy|IDjDZXNscSluIFnDOVA:OC5yMEi1{txONg>? NVvPZ|ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUC0O|kzQTNpPkGwOFc6Ojl|PD;hQi=>
MDA-MB-435 MUDGeY5kfGmxbjDhd5NigQ>? NF3LUWdKdmirYnn0bY9vKGGpYXnud5QhVUSDLV3CMVQ{PSCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{KGmwIITo[UBi[nOnbnPlJI9nKEiVQTygTWM2OD1yLkCxOe69VS5? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB3MkiwNkc,OTFyNUK4NFI9N2F-
MDA-MB-435 NEPxdnhHfW6ldHnvckBie3OjeR?= NHvweGdKdmirYnn0bY9vKGGpYXnud5QhVUSDLV3CMVQ{PSCqdX3hckBjemWjc4SgZ4Fv[2W{IHPlcIx{KGmwIITo[UBxemW|ZX7j[UBw\iBzMTDt[{9uVCCKU1GsJGlEPTB;MD6zO|XPxE1w NWnJTJFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwOVI5ODJpPkGxNFUzQDB{PD;hQi=>
Jurkat M4jPdWZ2dmO2aX;uJIF{e2G7 M4\1[2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBLfXKtYYSgbJVu[W5ibHX1b4VucWFiY3XscJMtKEmFNUC9NE4xODV4zszNMi=> M3u2RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{i0NlQ2Lz5zMUO4OFI1PTxxYU6=
P388 MYTGeY5kfGmxbjDhd5NigQ>? MXrJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgVFM5QCCvdYLpcoUhdGW3a3XtbYEh[2WubIOsJGlEPTB;MD6wNVPPxE1w MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN6NEK0OUc,OTF|OESyOFU9N2F-
Lewis lung carcinoma cells Mle4SpVv[3Srb36gZZN{[Xl? MlXaTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGxmf2m|IHz1coch[2G{Y3nuc41iKGOnbHzzMEBKSzVyPUCuNFM{|ryPLh?= NWiwenB7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzPFQzPDVpPkGxN|g1OjR3PD;hQi=>
A549 MYfGeY5kfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJJRweG:rc3;t[ZJie2ViMTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGOxbo\ldpNqd25ib3[gd5Vx\XKlb3ns[YQheEKUM{KyJGRPSSC2bzDy[YxigGWmIH\vdo0tKEmFNUC9OO69VS5? M4mxT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEOwNFAyLz5zMUSzNFAxOTxxYU6=
HeLa MXnGeY5kfGmxbjDhd5NigQ>? NIrMcmNKdmirYnn0bY9vKHSxcH;pd49u\XKjc3WgNUBqdiCqdX3hckBJ\UyjIHPlcIx{KGG|c3Xzd4VlKGG|IHPvcpZmenOrb36gc4Yhe3WyZYLjc4lt\WRicFLSN|IzKESQQTD0c{Bz\WyjeHXkJIZwem1uIFnDOVA:Qc7:TT6= NU\1R3h7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG0N|AxODFpPkGxOFMxODBzPD;hQi=>
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HT-29 NFT0WJJEgXSxdH;4bYNqfHliYYPzZZk> MmXTOFghcHK| NF;vT3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCneIDy[ZN{cW6pIIC1N{BufXSjboSgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1yLkVOwG0v NXy5OnR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NVU{OTlpPkG5O|E2OzF7PD;hQi=>
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MDA-MB-231 MnHxR5l1d3SxeHnjbZR6KGG|c3H5 M3mzXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPjkQvF2u Mm\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6M{[yN|EoRjF7OEO2NlMyRC:jPh?=
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HT1080 NGjleWpEgXSxdH;4bYNqfHliYYPzZZk> NV\1NI17S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRzMEiwJINmdGy|LDDJR|UxRTBwMElOwG0v NHnCOJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC5OVE{OSd-MkGwPVUyOzF:L3G+
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HT-29 MX7DfZRwfG:6aXPpeJkh[XO|YYm= MlfGO|IhcHK| MmP4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhXEeLPUOxMlYz|ryPLh?= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUKxNEc,OjFzMUWyNVA9N2F-
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RD MXrDfZRwfG:6aXPpeJkh[XO|YYm= MVi3NkBpenN? NW\ifoZmS3m2b4TvfIlkcXS7IHnuJIh2dWGwIGLEJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTRwNEpOwG0v NGTqeY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|M5Oid-Mki5NlM{QDJ:L3G+
A549 NWrE[HB5S3m2b4TvfIlkcXS7IHHzd4F6 NFvTO|M4OiCqcoO= MojER5l1d3SxeHnjbZR6KGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QC56N988UU4> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{M{O4Nkc,Ojh7MkOzPFI9N2F-
HCT16 MUPDfZRwfG:6aXPpeJkh[XO|YYm= M2THVFczKGi{cx?= NHLyU2REgXSxdH;4bYNqfHliaX6gbJVu[W5iSFPUNVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUKuN|TPxE1w M3PR[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUKzN|gzLz5{OEmyN|M5OjxxYU6=
MCF7 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NWPJPJFRPzJiaILz NIDRNnVEgXSxdH;4bYNqfHliaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMz62Nu69VS5? MlK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7MkOzPFIoRjJ6OUKzN|gzRC:jPh?=
TE32 MkiwR5l1d3SxeHnjbZR6KGG|c3H5 M4n1UFczKGi{cx?= MmnUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGU{OiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvOjUQvF2u Mn:yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7MkOzPFgoRjJ6OUKzN|g5RC:jPh?=
MS Mne0R5l1d3SxeHnjbZR6KGG|c3H5 M1jjSlczKGi{cx?= NWXpcYM{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yNjh2zszNMi=> NHrKWYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyN|M5QCd-Mki5NlM{QDh:L3G+
HCT116 NG\5U5JEgXSxdH;4bYNqfHliYYPzZZk> MY[3NkBpenN? M4\MOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTFwOElOwG0v MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{M{O4PEc,Ojh7MkOzPFg9N2F-
Hep2 NIPGVXBEgXSxdH;4bYNqfHliYYPzZZk> NHX5Zno4OiCqcoO= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZAzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9N{4xPM7:TT6= NUTzXIxvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5NlM{QDhpPkK4PVI{Ozh6PD;hQi=>
A549 NHHGZ5dEgXSxdH;4bYNqfHliYYPzZZk> M1[0dlczKGi{cx?= MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OU46O87:TT6= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{M{O4PEc,Ojh7MkOzPFg9N2F-
A549 NHjvNZZEgXSxdH;4bYNqfHliYYPzZZk> M17Tc|czKGi{cx?= NETITHpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xODh4M988UU4> NHHqeo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEmyO|c6OCd-Mki5Nlc4QTB:L3G+
KBVIN NX\GXXZbS3m2b4TvfIlkcXS7IHHzd4F6 NXfufXQ5PzJiaILz M{iwRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDXkmQIHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOTV5zszNMi=> M13ycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3O|kxLz5{OEmyO|c6ODxxYU6=
KB M3PrfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2rielczKGi{cx?= MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRkBk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTBwMEZOwG0v MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{e5NEc,Ojh7Mke3PVA9N2F-
MCF7 M{HSTWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXu3NkBpenN? MnvpR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuNFg4Pc7:TT6= NUXSdYFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc4QTBpPkK4PVI4PzlyPD;hQi=>
MDA-MB-231 MoXqR5l1d3SxeHnjbZR6KGG|c3H5 MlXkO|IhcHK| NXP5c3RZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUCuN|A4|ryPLh?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl{N{e5NEc,Ojh7Mke3PVA9N2F-
HL60 MmexRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXW3NkBpenN? M3fXfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDh[pRmeiB5MjDodpMh[nlidIL5dIhidiCkbIXlJJN1[WmwaX7nJIJie2WmIHjlcYF1d2O7dH;t[ZRzcWNibXX0bI9lNCCLQ{WwQVAvQTMQvF2u NEL5UVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGzNVYyPid-MkmxN|E3OTZ:L3G+
PC3 NFTiZ5VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXvhbIUxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwQVYvQTcQvF2u NFq1foE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUGzNVYyPid-MkmxN|E3OTZ:L3G+
HL60 MlTQR5l1d3SxeHnjbZR6KGG|c3H5 NEO3RVM1QCCqcoO= MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhSVSSbHn0[U1j[XOnZDDseY1qdmW|Y3XueEBie3OjeTygTWM2OD1yLkCy{txONg>? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
HL60 M2m3NmFxd3C2b4Ppd{Bie3OjeR?= MUeyOEBpenN? MVzJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4F{eGG|ZTCzM|ch[WO2aY\peJkh[W[2ZYKgNlQhcHK|IHL5JINie3Cjc3Wt[4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCLQ{WwQVAvODgQvF2u MkLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{MkOwPVkoRjJ7MkKzNFk6RC:jPh?=
K562 M4DPSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NF7XPJg1QCCqcoO= M4XZN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCDVGDsbZRmNWKjc3XkJIx2dWmwZYPj[Y51KGG|c3H5MEBKSzVyPUCuNFnPxE1w MoDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{MkOwPVkoRjJ7MkKzNFk6RC:jPh?=
MCF7 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NHficHQ1QCCqcoO= MmOxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KEGWUHzpeIUu[mG|ZXSgcJVucW6nc3PlcpQh[XO|YYmsJGlEPTB;MD6zOO69VS5? NHruN|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|A6QSd-MkmyNlMxQTl:L3G+
PC3 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NYrSXGdTPDhiaILz NYT5Z4RtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliQWTQcIl1\S2kYYPl[EBtfW2rbnXzZ4VvfCCjc4PhfUwhUUN3ME2wMlTPxE1w NHjIOGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|A6QSd-MkmyNlMxQTl:L3G+
HepG2 M3Hhd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NV:wfW9JPDhiaILz M3\rfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliQWTQcIl1\S2kYYPl[EBtfW2rbnXzZ4VvfCCjc4PhfUwhUUN3ME2wMlQ{|ryPLh?= NFe1R3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|A6QSd-MkmyNlMxQTl:L3G+
K562 M4LMfmFxd3C2b4Ppd{Bie3OjeR?= MVKyOEBpenN? M4TOZmlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bk[XOyYYPlJFMwPyCjY4Tpeol1gSCjZoTldkAzPCCqcoOgZpkh[2G|cHHz[U1odG9ibIXtbY5me2OnboSgZZN{[XluIFnDOVA:OC55MUJOwG0v NGexW2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUKyN|A6QSd-MkmyNlMxQTl:L3G+
HepG2 M4TOWGFxd3C2b4Ppd{Bie3OjeR?= M1HFcFI1KGi{cx?= NHjsPIpKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGOjc4Dhd4UhOy95IHHjeIl3cXS7IHHmeIVzKDJ2IHjyd{BjgSClYYPwZZNmNWeubzDseY1qdmW|Y3XueEBie3OjeTygTWM2OD12LkO3{txONg>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
RPE1 MWXBdI9xfG:|aYOgZZN{[Xl? MXmyOEBpenN? Ml22TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCUUFWxJINmdGy|IHHzd4V{e2WmIHHzJINie3Cjc3WgN{84KGGldHn2bZR6KGGodHXyJFI1KGi{czDifUBk[XOyYYPlMYdtdyCudX3pcoV{[2WwdDDhd5NigSxiSVO1NF0zPy5{zszNMi=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ{M{C5PUc,Ojl{MkOwPVk9N2F-
Sf9 M2ruOWZ2dmO2aX;uJIF{e2G7 MYmxNEB1dyB3MDD1US=> M4C3O|MxKG2rboO= NVH5cIFIW3SjYnnsbZpifGmxbjDv[kBz\WOxbXLpcoFvfCCqdX3hckB1d3CxaYPvcYVz[XOnLUGtd5Vx\XKlb3ns[YQheEKVIGPLLEsqKESQQTDjcIVifmGpZTDjc41xdGW6IHH0JFExKHSxIEWwJJVOKGGodHXyJFMxKG2rboOgeZNqdmdidH;wc4l{d22ncnHz[VEh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJEBk\WyuczDifUBmfGirZHn1cUBjem:vaXTlJJN1[WmwaX7nJIJie2WmIHHnZZJwe2ViZ3XsJIVt\WO2cn;wbI9z\XOrczDt[ZRp NHLwVFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK5NFExQSd-MkmyPVAyODl:L3G+
MCF7 NVTLelV[TnWwY4Tpc44h[XO|YYm= M1y5UFExKHWP M2jBOFEzKGi{cx?= M2Toe3N1[WKrbHn6ZZRqd25ib3[geI9xd2m|b33ldoF{\S1zLTDn[Y5wdWmlIFTORUBkdGWjdnHn[UBkd22ybHX4JIlvKGi3bXHuJG1ETjdiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNVIhcHK|IHL5JGlETSCjc4PhfS=> MmPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{OUCxNFkoRjJ7MkmwNVA6RC:jPh?=
HCT15 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2nwT|czKGi{cx?= MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEG1JINmdGy|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KEOFS{igZZN{[XluIFnDOVA:OC5yNd88UU4> MmnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEK3OFEoRjJ7NECyO|QyRC:jPh?=
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VACO 241 MojuSpVv[3Srb36gZZN{[Xl? MVLJcohq[mm2aX;uJI9nKESQQTD0c5BwcXOxbXXyZZNmKDFiaX6gTI9udyC|YYDp[Y5{KCiqdX3hckkhXkGFTzCyOFEh[2WubIOsJGlEPTB;ND65Oe69VS5? NHj5S|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
SAS NYjDOoFNSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYTvV2ZEPzJiaILz MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFODUzDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ou69VS5? NFzG[HQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
MDA-MB-231 MkDBR5l1d3SxeHnjbZR6KGG|c3H5 NGfyVGc1QCCqcoO= MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTZwNEVOwG0v Ml;jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
PC3 M2nBPWN6fG:2b4jpZ4l1gSCjc4PhfS=> MljkOFghcHK| MnLmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUiuNlTPxE1w NXj6eHBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
AGS Ml3WRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEfDN4w4OiCqcoO= NU\QNJhsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBS3Mh[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTJ|Lke2{txONg>? MmfRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
MCF7 NI\KWIVHfW6ldHnvckBie3OjeR?= MmHPNVAhfU1? M3TPdVEzKGi{cx?= NHLwVGVRd2m|b37pcoch[WO2aY\peJkh[XRidH;wc4l{d22ncnHz[UAyKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOTJiaILzJIJ6KGmvbYXuc4JidmRiZHXwcIV1cW:wIHHzd4F6 NX\ZTpZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
A549 NUXqfZpNSXCxcITvd4l{KGG|c3H5 MnXqNVIhfG9iMUWgbJJ{ M4TGWWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{Bnd3KvYYTpc44hd2ZiYYDvdJRwfGmlIHLv[IlmeyCjZoTldkAyOiC2bzCxOUBpenNiYomg[oxwfyCleYTvcYV1emmlIH3leIhw\A>? MmHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
A549 MWDBdI9xfG:|aYOgZZN{[Xl? MkfiNVIhfG9iMUWgbJJ{ NGXlU2NKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDjc45l\W6|YYTpc44h[W[2ZYKgNVIhfG9iMUWgbJJ{KGK7IH\sc5ch[3m2b33leJJq[yCvZYToc4Q> MlezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
MDA-MB-231 Mn35R4VtdCCleXPs[UBie3OjeR?= NEn5RlcyKHWP NVqxWWJsOTZiaILz M1O1fWNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JHMueGijc3WgZZQhOSC3TTDpcoN2[mG2ZXSg[o9zKDF4IHjyd{BjgSCobH;3JIN6fG:vZYTyfS=> M1fJeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin1 / CDK1 / CDK2 ; 

PubMed: 29963130     


Western blot analysis indicated that camptothecin (6 µM) downregulates the expression of cell-cycle-associated proteins, cyclin 1, CDK1 and CDK2 in NPC cells. β-actin was used as a loading control.

Vimentin / Fibronectin / E-cadherin ; 

PubMed: 29963130     


Western blot analysis revealed that camptothecin (6 µM) treatment downregulates the expression of vimentin and fibronectin, and upregulates the expression of E-cadherin in NPC cells. β-actin was used as a loading control. NPC, nasopharyngeal carcinoma.

TGF-β / PI3K / pPI3K / AKT / pAKT ; 

PubMed: 29963130     


Western blot analysis revealed that camptothecin (6 µM) treatment inhibits the expression of TGF-β, PI3K and AKT in NPC cells. 

p53 / Cleaved caspase-3 / Cleaved PARP ; 

PubMed: 17548347     


NPCs in trophic factor-containing media were treated with 10 μM camptothecin for 0, 2, 4, 6, or 8 h, and extracts were immunoblotted for p53, active cleaved caspase-3, cleaved PARP, and total GSK3α/β as a loading control.

29963130 17548347
In vivo Camptothecin (8 mg/kg) displays complete growth inhibition and regression in mice xenografts of various tumors, including colon, lung, breast, stomach, and ovary tumors. [3] In mice, combinations of Camptothecin (50 mg/kg) and TNF (5 and 7 μg/kg), but not Camptothecin alone, induces liver damage. [4]

Protocol

Kinase Assay:[2]
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Topoisomerase I Cleavable Complex Assay:

Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine
Cell Research:[2]
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  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 0.17 nM–10 mM
  • Incubation Time: 48 hours
  • Method: Tumor cells are plated in 100 μL of medium in 96-well microtiter plates at a density of 1500 to 4000 cells per well and allowed to adhere overnight. Cells are incubated with Camptothecin for 48 hours and then with fresh medium for 48 hours. Camptothecin at each concentration is added in quadruplicate. Following a 4-hour incubation of treated cells with MTT, the reduced dye product is extracted from the cells with 0.2 mL of DMSO followed by 50 μL of Sorensen's buffer. The plates are shaken briefly, and the absorbance at 570 nm is read and quantitated. Curves are fitted to the MTT assay data using a four-parameter logistic equation.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Nude mice (NIH-I high fertility strain) bearing xenografts of CASE, SW48, DOY, SPA, and CLO cells
  • Dosages: 0–8 mg/kg
  • Administration: Administered via i.m. or i.v. injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 3 mg/mL (8.61 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.35
Formula

C20H16N2O4

CAS No. 7689-03-4
Storage powder
in solvent
Synonyms CPT, Campathecin, (S)-(+)-Camptothecin
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04419272 Not yet recruiting Drug: Methylphenidate|Other: Placebo Epilepsy VA New York Harbor Healthcare System|Portland VA Medical Center|Miami VA Healthcare System April 2022 Phase 4
NCT04657289 Not yet recruiting Drug: PDS Implant filled with 100 mg/mL Ranibizumab Neovascular Age-related Macular Degeneration (nAMD) Hoffmann-La Roche May 6 2021 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID