Camptothecin (NSC-100880)

Catalog No.S1288 Synonyms: CPT, Campathecin, (S)-(+)-Camptothecin

For research use only.

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.

Camptothecin (NSC-100880) Chemical Structure

CAS No. 7689-03-4

Selleck's Camptothecin (NSC-100880) has been cited by 106 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Targets
Topo I [2]
(Cell-free assay)
0.68 μM
In vitro

Camptothecin, a plant alkaloid orignially isolated from Camptotheca acuminate in 1966. [1] Camptothecin is noted to halt cells during the S phase of mitosis. Camptothecin displays nanomolar potency in cytotoxicity against many human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB, with IC50 values ranging from 37 nM to 48 nM. [2] In combination with TNF, Camptothecin induces apoptosis in primary mouse hepatocytes, with an IC50 value of 13 μM. Camptothecin also abrogated the TNF-induced NF-κB Activation, as well as the expression of TNF-receptor associated factor 2 (TRAF2), X-linked inhibitor of apoptosis protein (X-IAP), and FLICE-inhibitory protein (FLIP). [4] In HCT116 cells, Camptothecin (5 μM) induces proteasome-mediated degradation of mixed lineage leukemia 5 (MLL5) protein, which leads to phosphorylation of p53 at Ser392. [5] Due to the low solubility and adverse effects of Camptothecin, various Camptothecin analogues have been developed, and two of them, topotecan and irinotecan, has been approved by FDA and are used in cancer chemotherapy.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
P388 MUfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NUDLeHNxUUN3ME2zNkBvVQ>? M2TlS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{S2PVM{Lz5zMEO0Olk{OzxxYU6=
P388CPT5 R NUj3dJFoT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= Moj5TWM2OD1{Lkig{txO NE\BZlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEO0Olk{Oyd-MUCzOFY6OzN:L3G+
KBwt M3Hlc2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MXXJR|UxRTRyIH7N NHy2Z|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMESxNVQ4Pid-MUC0NVE1PzZ:L3G+
KBMDR MXrHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NEXSRlZKSzVyPUewJI5O MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODRzMUS3Okc,OTB2MUG0O|Y9N2F-
KBV20C NGXTbYtIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M2SyS2lEPTB;M{Cgcm0> NFP2cmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMESxNVQ4Pid-MUC0NVE1PzZ:L3G+
KB7D MoriS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWn5T21VUUN3ME2zOUBvVQ>? NEO2WlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMESxNVQ4Pid-MUC0NVE1PzZ:L3G+
KBCamp NHnjeWlIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NIPa[|BKSzVyPUGuNFQh|ryP M3XXXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyNEGxOFc3Lz5zMESxNVQ4PjxxYU6=
HT29 M3rr[IN6fG:2b4jpZ4l1gSCjc4PhfS=> NUHsflBMUUN3ME24NEBvVQ>? NETUeI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEi0NVgxQCd-MUC4OFE5ODh:L3G+
A549 NIfXS5NkgXSxdH;4bYNqfHliYYPzZZk> NIPj[WRKSzVyPU[3JI5O MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh2MUiwPEc,OTB6NEG4NFg9N2F-
T24 M4WxZ4N6fG:2b4jpZ4l1gSCjc4PhfS=> MYjJR|UxRTh6IH7N M3fRSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOESxPFA5Lz5zMEi0NVgxQDxxYU6=
HOP-62 MmP3S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M3LzNGlEPTB;MUCgcm0> Mkn1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
HCT-116 M3vZTmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NF;VWY5KSzVyPUOwJI5O MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
SF-539 MXTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NU[weXhDUUN3ME2xNEBvVQ>? MkXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
UACC-62 M3HqS2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NFfUcodKSzVyPUGwJI5O MkHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTFyMkCyPFMoRjFzMEKwNlg{RC:jPh?=
OVCAR-3 NF7mN3JIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M2PG[2lEPTB;MkKwJI5O MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTB{MEK4N{c,OTFyMkCyPFM9N2F-
SN12C NX;hR5FnT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MWnJR|UxRTJyIH7N M2rTTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMEKwNlg{Lz5zMUCyNFI5OzxxYU6=
DU-145 MmXSS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? Mk[0TWM2OD1zMDDuUS=> NILSfHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCyNFI5Oyd-MUGwNlAzQDN:L3G+
MDA-MB-435 MoKyS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NUHtWGpTUUN3ME20NEBvVQ>? NUHteZY5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGwNlAzQDNpPkGxNFIxOjh|PD;hQi=>
WiDr M3PEZYN6fG:2b4jpZ4l1gSCjc4PhfS=> NEDRUpBFVVOR Mo\YTWM2OD1zNzDuUS=> MmTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
A549 M2TDWYN6fG:2b4jpZ4l1gSCjc4PhfS=> NF\meY5FVVOR NX3MZ5RGUUN3ME2xOEBvVQ>? M2njR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
MKN45 NFi2SJFkgXSxdH;4bYNqfHliYYPzZZk> MUfEUXNQ MoXnTWM2OD1zNzDuUS=> MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTN|NEW2PUc,OTF|M{S1Olk9N2F-
SK-OV-3 NFyzbJhkgXSxdH;4bYNqfHliYYPzZZk> NUTRNWVZTE2VTx?= M3XUN2lEPTB;MkCgcm0> Mn\3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF|M{S1OlkoRjFzM{O0OVY6RC:jPh?=
H128 MV;jfZRwfG:6aXPpeJkh[XO|YYm= NEnQdZVFVVOR MWHJR|UxRTF6IH7N M1\Dd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{O0OVY6Lz5zMUOzOFU3QTxxYU6=
SK-BR-3 M3zleYN6fG:2b4jpZ4l1gSCjc4PhfS=> MljxSG1UVw>? MX3JR|UxRTJyIH7N NX23Z4Q3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjlpPkGxN|M1PTZ7PD;hQi=>
LX-1 Mn2zZ5l1d3SxeHnjbZR6KGG|c3H5 MVPEUXNQ NXjhfolSUUN3ME2xNlAhdk1? NIC0b2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUi1PFc{Pyd-MUG4OVg4Ozd:L3G+
HCT116 NV3lcIps[3m2b4TvfIlkcXS7IHHzd4F6 M2HKe2ROW09? NV;ObJNYUUN3ME25JI5O MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTh3OEezO{c,OTF6NUi3N|c9N2F-
A2780 NYXORnh4[3m2b4TvfIlkcXS7IHHzd4F6 M1KzeGROW09? MWTJR|UxRTRibl2= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTh3OEezO{c,OTF6NUi3N|c9N2F-
IMR-32 NWL4S3NO[3m2b4TvfIlkcXS7IHHzd4F6 NH;YRZV,OTBizszN NEDqNmZFVVOR NVG4WlVyUUN3ME2yMlIyKG6P M{nQeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkG3PFk1Lz5zMk[xO|g6PDxxYU6=
P388 MoLQZ5l1d3SxeHnjbZR6KGG|c3H5 NXK1cI9oUUN3ME2xN{BvVQ>? NE\URmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[yNFA5OSd-MUK2NlAxQDF:L3G+
Lewis M4TtPIN6fG:2b4jpZ4l1gSCjc4PhfS=> NGCyWI5KSzVyPUOzJI5O Mni4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4MkCwPFEoRjF{NkKwNFgyRC:jPh?=
JLC NG\xT4dkgXSxdH;4bYNqfHliYYPzZZk> NGXIPFFKSzVyPUWuOkBvVQ>? M1KxcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkKwNFgyLz5zMk[yNFA5OTxxYU6=
HT-29 MXrjfZRwfG:6aXPpeJkh[XO|YYm= Mnn1TWM2OD1zLkSg{txO Mo[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4M{m1OFEoRjF{NkO5OVQyRC:jPh?=
Caki-2 NH23WXJkgXSxdH;4bYNqfHliYYPzZZk> M3rLZmlEPTB;Mz65OkDPxE1? MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ|OUW0NUc,OTJ4M{m1OFE9N2F-
A549 M3nXc4N6fG:2b4jpZ4l1gSCjc4PhfS=> M3f0emlEPTB;Mj61N{DPxE1? M2frNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO5OVQyLz5zMk[zPVU1OTxxYU6=
HEC-1-B NVzXdnJn[3m2b4TvfIlkcXS7IHHzd4F6 MWLJR|UxRThwNkSg{txO NUPiR3d[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
HL-60 M1rQfoN6fG:2b4jpZ4l1gSCjc4PhfS=> M1K3W2lEPTB;Nk[gcm0> NUjyNmVlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2N|k2PDFpPkGyOlM6PTRzPD;hQi=>
Col2 MWnjfZRwfG:6aXPpeJkh[XO|YYm= NWjxPYtMhjFizszN MoLpSWQ2OD13NzDuUS=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
HUVEC Ml;CZ5l1d3SxeHnjbZR6KGG|c3H5 M4HNNZ4yKM7:TR?= Ml\6SWQ2OD1{NUigcm0> NWnxWVZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
KB NF\zOVBkgXSxdH;4bYNqfHliYYPzZZk> NWPUd4F5hjFizszN MmWzSWQ2OD1{MjDuUS=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
LCNaP MknSZ5l1d3SxeHnjbZR6KGG|c3H5 MmHOglEh|ryP MXLFSFUxRTJ6IH7N MnLzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
Lu1 NYHKSnVR[3m2b4TvfIlkcXS7IHHzd4F6 NIqxcFV,OSEQvF2= NX\RXVhLTUR3ME2yPUBvVQ>? NH23SWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
RPMI8402 MUPjfZRwfG:6aXPpeJkh[XO|YYm= NULQUGJ1hjFyIN88US=> NULxZWdxUUN3ME22JI5O M1TpSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
CPT-K5 MXnjfZRwfG:6aXPpeJkh[XO|YYm= Mlz6glExKM7:TR?= MYHJR|UxRjFyIN88US=> MmDxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
P388 NFT3Om9kgXSxdH;4bYNqfHliYYPzZZk> MVL+NVAh|ryP NHPBTopKSzVyPUG0JI5O M4rqN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
P388/CPT45 M1f1U4N6fG:2b4jpZ4l1gSCjc4PhfS=> NV\H[Ww{hjFyIN88US=> M13xcGlEPTB-MUCg{txO MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
KB3-1 NIrlTnBkgXSxdH;4bYNqfHliYYPzZZk> MVj+NVAh|ryP MkLkTWM2OD12MDDuUS=> M4SxNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NEiyPVI6Lz5zNUS4NlkzQTxxYU6=
KBV-1 + MDR1 NYjtdnJ3[3m2b4TvfIlkcXS7IHHzd4F6 MkG1glExKM7:TR?= MVvJR|UxRTR2MDDuUS=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTR6MkmyPUc,OTV2OEK5Nlk9N2F-
KBH Mk[1Z5l1d3SxeHnjbZR6KGG|c3H5 NGXvW|F,OTBizszN M{\mXGlEPTB;NESwJI5O MoO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEK5NlkoRjF3NEiyPVI6RC:jPh?=
HOP-62 MWLjfZRwfG:6aXPpeJkh[XO|YYm= MYX+NVAh|ryP MXPHTVUxRTFyIH7N M3eyUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
HCT-116 M4mycIN6fG:2b4jpZ4l1gSCjc4PhfS=> MVr+NVAh|ryP Mn\US2k2OD1|MDDuUS=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
F-539 M3HZO4N6fG:2b4jpZ4l1gSCjc4PhfS=> M3i1ep4yOCEQvF2= NFXZcnBIUTVyPUGwJI5O MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
UACC-62 NUTEOYRJ[3m2b4TvfIlkcXS7IHHzd4F6 NILWVpN,OTBizszN MVXHTVUxRTFyIH7N MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTVyOUG2OEc,OTV3MEmxOlQ9N2F-
OVCAR-3 MVPjfZRwfG:6aXPpeJkh[XO|YYm= NHfRWHB,OTBizszN MYTHTVUxRTJ{MDDuUS=> M4CwNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUC5NVY1Lz5zNUWwPVE3PDxxYU6=
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HCT116 NGnHb3dEgXSxdH;4bYNqfHliYYPzZZk> MYi3NkBpenN? MmfsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OS56ON88UU4> M{THUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUKzN|g5Lz5{OEmyN|M5QDxxYU6=
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KBVIN NGS5eZlEgXSxdH;4bYNqfHliYYPzZZk> MXy3NkBpenN? M2HEPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDXkmQIHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4xOTV5zszNMi=> M1;GTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUK3O|kxLz5{OEmyO|c6ODxxYU6=
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MDA-MB-231 NFjLWVFEgXSxdH;4bYNqfHliYYPzZZk> MYG3NkBpenN? M17kN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1yLkOwO:69VS5? NXnwe3VuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5Nlc4QTBpPkK4PVI4PzlyPD;hQi=>
HL60 MorqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn;rO|IhcHK| Mo[wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKTE[wJINmdGy|IHHmeIVzKDd{IHjyd{BjgSC2conwbIFvKGKudXWgd5RicW6rbnegZoF{\WRiaHXtZZRw[3m2b33leJJq[yCvZYToc4QtKEmFNUC9NE46Os7:TT6= Mln3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzM{G2NVYoRjJ7MUOxOlE3RC:jPh?=
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PANC1 NITKZYtEgXSxdH;4bYNqfHliYYPzZZk> NFHqe204OiCqcoO= NUe3S4J3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFiWVDDhd5NigSxiSVO1NF0xNjB7zszNMi=> NF;STZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MECxO|EyPCd-M{CwNVcyOTR:L3G+
PANC1 NFXJboZEgXSxdH;4bYNqfHliYYPzZZk> MoXoOFghcHK| NVnlVphuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEGQQ{GgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NF0xNjF6zszNMi=> NYfVR2FqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNVcyOTRpPkOwNFE4OTF2PD;hQi=>
Capan1 NH\XVmlEgXSxdH;4bYNqfHliYYPzZZk> Mkf5O|IhcHK| NGjiWHJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[XCjbkGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFiWVDDhd5NigSxiSVO1NF0xNjJzzszNMi=> MmfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByMUexNVQoRjNyMEG3NVE1RC:jPh?=
CNE2 NHHs[XJEgXSxdH;4bYNqfHliYYPzZZk> MVi0PEBpenN? MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDUmUzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOc7:TT6= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB{NUO0OEc,OzByMkWzOFQ9N2F-
A549 M2DaUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkTvOFghcHK| NUnwZ2FHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13LkZOwG0v NYDJclBrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNlU{PDRpPkOwNFI2OzR2PD;hQi=>
HepG2 M4XOXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYPsdIc3PDhiaILz M4jGOWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF|LkNOwG0v M2[0VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEK1N|Q1Lz5|MECyOVM1PDxxYU6=
K562 M1iw[GFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXK0PEBpenN? M4i2S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwMEhOwG0v NYCwXlJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwOVU1PjVpPkOwNFU2PDZ3PD;hQi=>
HepG2 NHnuUmtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVu0PEBpenN? NGXKWIZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD6zO:69VS5? MnXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByNUW0OlUoRjNyMEW1OFY2RC:jPh?=
CNE1 MnnoRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M2HaOVczKGi{cx?= NEDZOIVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPOSVEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkO0{txONg>? MoLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzMkW3NlUoRjNyMUK1O|I2RC:jPh?=
MCF7 NVywO3FsSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NW\uVG96PzJiaILz NUL4S5BVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD60Nu69VS5? NUXuWXFZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNlU4OjVpPkOwNVI2PzJ3PD;hQi=>
HeLa NGLje29CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M3e0NVczKGi{cx?= NH7xXYdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLk[2{txONg>? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF{NUeyOUc,OzBzMkW3NlU9N2F-
CNE2 NXrTd21ySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MknDO|IhcHK| MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOQRUKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjl6zszNMi=> NHLiWXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGyOVczPSd-M{CxNlU4OjV:L3G+
SMMC7721 MnKyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIHHfoE4OiCqcoO= MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOPTVO3O|IyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT6wPO69VS5? NXriWINqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxNlU4OjVpPkOwNVI2PzJ3PD;hQi=>
HepG2 MmT5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{HXVFczKGi{cx?= M2jie2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zLkO2{txONg>? M2PJ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUK1O|I2Lz5|MEGyOVczPTxxYU6=
HepG2 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MW[0PEBpenN? M1zRZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD14LkC4{txONg>? MmPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzMkW3NlUoRjNyMUK1O|I2RC:jPh?=
HCT15 MlvkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYT2PFBqPzJiaILz MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEG1JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCHWj3DXXRQYCC{ZXHn[Y51KGKjc3XkJIF{e2G7LDDJR|UxRTBwMEZOwG0v Mm\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NkKxN|IoRjNyMk[yNVMzRC:jPh?=
T47D NUHUdZZZSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2fDWVczKGi{cx?= M2ftVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iVES3SEBk\WyuczDh[pRmeiB5MjDodpMh[nliRWqtR3lVV1hicnXh[4VvfCCkYYPl[EBie3OjeTygTWM2OD1yLkC3{txONg>? MkPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NkKxN|IoRjNyMk[yNVMzRC:jPh?=
HeLa MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MlfqO|IhcHK| M4XqW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB5MjDodpMh[nliRWqtR3lVV1hicnXh[4VvfCCkYYPl[EBie3OjeTygTWM2OD1zLkO3{txONg>? Mn7MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NkKxN|IoRjNyMk[yNVMzRC:jPh?=
CCRF-CEM NEK0PW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MY[3NkBpenN? M2LHVGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFfJOVA:OC5yMEhOwG0v NIfRVpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEOzOlAzOyd-M{CzN|YxOjN:L3G+
HCT116 MkXaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17CdVczKGi{cx?= NYThOGNsT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFfJOVA:OC5yMEpOwG0v MoPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|M{[wNlMoRjNyM{O2NFI{RC:jPh?=
DU145 NInKRYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUW3NkBpenN? NIjYVFhIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBFXTF2NTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVAvODJzzszNMi=> NETieVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEOzOlAzOyd-M{CzN|YxOjN:L3G+
HCT116 NEnncIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\JO|IhcHK| NU[0UJA5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUG2JINmdGy|IHX4dJJme3OrbnegWG9ROSC|aWLORUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBIUTVyPUCuNFc2|ryPLh?= MnzuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|M{[wNlMoRjNyM{O2NFI{RC:jPh?=
HuH7 MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2\RbVczKGi{cx?= MnO5S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTJVJPyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBIUTVyPUCuNFk6|ryPLh?= NWj6S3NbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzN|YxOjNpPkOwN|M3ODJ|PD;hQi=>
A549 NWq2Z|VZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPnO|IhcHK| M16xNWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhT0l3ME2wMlIy|ryPLh?= NETDXok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEOzOlAzOyd-M{CzN|YxOjN:L3G+
RC0.1 M1rDT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWW3NkBpenN? NFzYWFRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBTSzBwMTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVQvPzQQvF2u NX7kS5V6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzN|YxOjNpPkOwN|M3ODJ|PD;hQi=>
MCF7 NYPRS5pHS3m2b4TvfIlkcXS7IHHzd4F6 MV:3NkBpenN? NED6NZNEgXSxdH;4bYNqfHliYXfhbY5{fCCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yNN88UU4> NWLpSlZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFA5QTlpPkOwN|QxQDl7PD;hQi=>
MS NYLCR2RrS3m2b4TvfIlkcXS7IHHzd4F6 M4nvXVczKGi{cx?= MkXTR5l1d3SxeHnjbZR6KGGpYXnud5Qh[WejaX7zeEBpfW2jbjDNV{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlc4|ryPLh?= NV32UFVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFA5QTlpPkOwN|QxQDl7PD;hQi=>
A549 MUTDfZRwfG:6aXPpeJkh[XO|YYm= MX23NkBpenN? MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NU4{Oc7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN2MEi5PUc,OzB|NEC4PVk9N2F-
HEK293 MXHDfZRwfG:6aXPpeJkh[XO|YYm= M1fU[VczKGi{cx?= MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT62Ne69VS5? NUXSblJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFA5QTlpPkOwN|QxQDl7PD;hQi=>
RD M{DvVmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVvIWIlHPzJiaILz MlPkR5l1d3SxeHnjbZR6KGGpYXnud5Qh[WejaX7zeEBpfW2jbjDSSEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xMlcz|ryPLh?= NWrvdpc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFA5QTlpPkOwN|QxQDl7PD;hQi=>
HCT116 M{HObmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2XheFczKGi{cx?= NIXrc3FEgXSxdH;4bYNqfHliYXfhbY5{fCCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zLki4{txONg>? MlLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|NEC4PVkoRjNyM{SwPFk6RC:jPh?=
Hep2 MkmwR5l1d3SxeHnjbZR6KGG|c3H5 MXS3NkBpenN? MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBi\2GrboP0JIh2dWGwIFjldFIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9N{4xOc7:TT6= Mm\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|NEC4PVkoRjNyM{SwPFk6RC:jPh?=
HCT116 NIWwNJVCdnSrbXnndoF1d3K7IHHzd4F6 MnXNNkB2VQ>? NGr6bYc6PiCqcoO= MnjKRY51cW2rZ4LheI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKQ2SxNVYh[2WubIOgZZQhOiC3TTDh[pRmeiB7NjDodpMh[nlid3;1coQhcGWjbHnu[{Bie3OjeR?= NF3JSmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO0NFg6QSd-M{CzOFA5QTl:L3G+
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LN229 NUDUPI5FS3m2b4TvfIlkcXS7IHHzd4F6 NGHwbXE1QCCqcoO= Mn;KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG4zOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JGNEUzhiYYPzZZktKEmFNUC9NE4xODB|Mt88UU4> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODdyMkK4Okc,OzB5MEKyPFY9N2F-
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HCT116 NGnMSVZHfW6ldHnvckBie3OjeR?= NG\MW3NKdmirYnn0bY9vKG:oIFTORUB1d3CxaYPvcYVz[XOnIEGgbY4hUG:vbzDzZZBq\W6|IDjoeY1idiliSFPUNVE3KGOnbHzzMEBKSzVyPUSuO|XPxE1w M3rxNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY2Nyd-Q3jFUWJNRC:jPh?=
VACO 241 NEi3cIlHfW6ldHnvckBie3OjeR?= NIDLTpVKdmirYnn0bY9vKG:oIFTORUB1d3CxaYPvcYVz[XOnIEGgbY4hUG:vbzDzZZBq\W6|IDjoeY1idiliVlHDU{AzPDFiY3XscJMtKEmFNUC9OE46Pc7:TT6= NUfXb3ZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
SAS MonBRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlLSO|IhcHK| M3nlZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1HTJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF03|ryPLh?= NUW4R4o{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPjVxJ{7DbGVOSkx:L3G+
MDA-MB-231 NILNeFFEgXSxdH;4bYNqfHliYYPzZZk> M1rTVFQ5KGi{cx?= MnvlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTF4LkS0{txONg>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OU8oRkOqRV3CUFww[T5?
PC3 Mnr6R5l1d3SxeHnjbZR6KGG|c3H5 MUK0PEBpenN? MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zOD6yOO69VS5? NF3QZo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
AGS NFTCXYtCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYW3NkBpenN? MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEGJUzDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlMvPzcQvF2u NHzWblg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
MCF7 NIS2T3ZHfW6ldHnvckBie3OjeR?= Mn\5NVAhfU1? M1jhSlEzKGi{cx?= NHvZ[W5Rd2m|b37pcoch[WO2aY\peJkh[XRidH;wc4l{d22ncnHz[UAyKGmwIHj1cYFvKE2FRkegZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOTJiaILzJIJ6KGmvbYXuc4JidmRiZHXwcIV1cW:wIHHzd4F6 MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly2OU8oRkOqRV3CUFww[T5?
A549 NIDaWo9CeG:ydH;zbZMh[XO|YYm= NILKPZMyOiC2bzCxOUBpenN? M3jkXWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{Bnd3KvYYTpc44hd2ZiYYDvdJRwfGmlIHLv[IlmeyCjZoTldkAyOiC2bzCxOUBpenNiYomg[oxwfyCleYTvcYV1emmlIH3leIhw\A>? NHKydFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
A549 MnXSRZBweHSxc3nzJIF{e2G7 NWPaWlhEOTJidH:gNVUhcHK| NHHTellKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDjc45l\W6|YYTpc44h[W[2ZYKgNVIhfG9iMUWgbJJ{KGK7IH\sc5ch[3m2b33leJJq[yCvZYToc4Q> NIDuT5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3PS9pPlPoSW1DVDxxYU6=
MDA-MB-231 M37we2NmdGxiY4njcIUh[XO|YYm= Mm\NNUB2VQ>? M{CzNlE3KGi{cx?= MW\D[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDTMZBp[XOnIHH0JFEhfU1iaX7jeYJifGWmIH\vdkAyPiCqcoOgZpkh\myxdzDjfZRwdWW2com= MmjIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlUwLz6FaFXNRmw9N2F-
Assay
Methods Test Index PMID
Western blot Cyclin1 / CDK1 / CDK2 ; Vimentin / Fibronectin / E-cadherin ; TGF-β / PI3K / pPI3K / AKT / pAKT ; p53 / Cleaved caspase-3 / Cleaved PARP 29963130 17548347
In vivo Camptothecin (8 mg/kg) displays complete growth inhibition and regression in mice xenografts of various tumors, including colon, lung, breast, stomach, and ovary tumors. [3] In mice, combinations of Camptothecin (50 mg/kg) and TNF (5 and 7 μg/kg), but not Camptothecin alone, induces liver damage. [4]

Protocol (from reference)

Kinase Assay:[2]
  • Topoisomerase I Cleavable Complex Assay:

    Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine

Cell Research:[2]
  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 0.17 nM–10 mM
  • Incubation Time: 48 hours
  • Method: Tumor cells are plated in 100 μL of medium in 96-well microtiter plates at a density of 1500 to 4000 cells per well and allowed to adhere overnight. Cells are incubated with Camptothecin for 48 hours and then with fresh medium for 48 hours. Camptothecin at each concentration is added in quadruplicate. Following a 4-hour incubation of treated cells with MTT, the reduced dye product is extracted from the cells with 0.2 mL of DMSO followed by 50 μL of Sorensen's buffer. The plates are shaken briefly, and the absorbance at 570 nm is read and quantitated. Curves are fitted to the MTT assay data using a four-parameter logistic equation.
Animal Research:[3]
  • Animal Models: Nude mice (NIH-I high fertility strain) bearing xenografts of CASE, SW48, DOY, SPA, and CLO cells
  • Dosages: 0–8 mg/kg
  • Administration: Administered via i.m. or i.v. injection

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 348.35
Formula

C20H16N2O4

CAS No. 7689-03-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05310097 Not yet recruiting Behavioral: CPT|Behavioral: MS PTSD Boston University|National Institute of Mental Health (NIMH) September 2022 Not Applicable
NCT05227742 Not yet recruiting Drug: Psilocybin|Drug: Placebo Demoralization University of Alabama at Birmingham|Diamond Therapeutics Inc. August 2022 Early Phase 1
NCT05461170 Not yet recruiting Drug: VIR-2218|Drug: VIR-3434 Hepatitis D Chronic Vir Biotechnology Inc. August 15 2022 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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