Chlorzoxazone

Synonyms: Chlorzoxazon,Paraflex

Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.

Chlorzoxazone Chemical Structure

Chlorzoxazone Chemical Structure

CAS: 95-25-0

Purity & Quality Control

Batch: S415501 DMSO] 34 mg/mL] false] Ethanol] 34 mg/mL] false] Water] Insoluble] false Purity: 99.8%
99.8

Chlorzoxazone Related Products

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
In vitro
In vitro

Chlorzoxazone is well documented to be metabolized mainly to 6-hydroxychlorzoxazone physically, which is catalyzed primarily by CYP2E1. Other human hepatic P450 enzymes, namely CYP1A1, CYP1A2 and CYP3A4 may also contribute to Chlorzoxazone metabolism. Chlorzoxazone has been used as a probe for CYP2E1 activity in microsomes from various sources (e.g., liver, kidney, lung cells) as well as directly in cell cultures. [1] Chlorzoxazone is a centrally acting skeletal muscle relaxant, which acts on the spinal cord by depressing reflexes. Chlorzoxazone is able to activate rat brain SK2 channel currents in cells. The maximal response to Chlorzoxazone is achieved at 1 mM, which is 44% ( 62%) of the response to 1 mM 1-EBIO. [2]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02654236 Completed
Alcohol Consumption
Suthat Liangpunsakul|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|Intercept Pharmaceuticals|Indiana University
April 2016 Not Applicable
NCT00138684 Completed
Insulin Resistance|Iron Overload
Rennes University Hospital|Ministry of Health France
September 2003 Phase 2

Chemical Information & Solubility

Molecular Weight 169.57 Formula

C7H4ClNO2

CAS No. 95-25-0 SDF Download Chlorzoxazone SDF
Smiles C1=CC2=C(C=C1Cl)NC(=O)O2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (200.5 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 34 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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