For research use only. Not for use in humans.

Catalog No.S4155

Chlorzoxazone Chemical Structure

Molecular Weight(MW): 169.57

Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.

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Biological Activity

Description Chlorzoxazone is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
In vitro

Chlorzoxazone is well documented to be metabolized mainly to 6-hydroxychlorzoxazone physically, which is catalyzed primarily by CYP2E1. Other human hepatic P450 enzymes, namely CYP1A1, CYP1A2 and CYP3A4 may also contribute to Chlorzoxazone metabolism. Chlorzoxazone has been used as a probe for CYP2E1 activity in microsomes from various sources (e.g., liver, kidney, lung cells) as well as directly in cell cultures. [1] Chlorzoxazone is a centrally acting skeletal muscle relaxant, which acts on the spinal cord by depressing reflexes. Chlorzoxazone is able to activate rat brain SK2 channel currents in cells. The maximal response to Chlorzoxazone is achieved at 1 mM, which is 44% ( 62%) of the response to 1 mM 1-EBIO. [2]


Solubility (25°C)

In vitro DMSO 34 mg/mL (200.5 mM)
Ethanol 34 mg/mL (200.5 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 169.57


CAS No. 95-25-0
Storage powder
in solvent
Synonyms N/A
Smiles ClC1=CC2=C(OC(=O)N2)C=C1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID