Home GPCR & G Protein Adenosine Receptor antagonist Ciforadenant (CPI-444) For research use only.

Ciforadenant (CPI-444)

Synonyms: V81444

Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.

Ciforadenant (CPI-444) Chemical Structure

Ciforadenant (CPI-444) Chemical Structure

CAS: 1202402-40-1

Selleck's Ciforadenant (CPI-444) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.98%
99.98

Ciforadenant (CPI-444) Related Products

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Biological Activity

Description Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes.
Targets
A2AR [1]
3.54 nM(Ki)
In vitro
In vitro

CPI-444 restores T-cell activation in vitro[1].
In Vivo
In vivo

CPI-444 treatment resulted in a similar inhibition of tumor growth in the B16F10 melanoma (100 mg/kg) and RENCA renal cell cancer syngeneic models (10 mg/kg). It enhances T-cell activation in both the periphery and tumor microenvironment[1].
Animal Research Animal Models C57BL/6 mice engrafted MC38 cells
Dosages 1, 10, or 100 mg/kg
Administration oral gavage

Chemical Information & Solubility

Molecular Weight 407.43 Formula

C20H21N7O3
CAS No. 1202402-40-1 SDF --
Smiles CC1=CC=C(O1)C2=C3C(=NC(=N2)N)N(N=N3)CC4=NC(=CC=C4)COC5CCOC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 81 mg/mL ( (198.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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