Calcitriol

Catalog No.S1466 Synonyms: RO215535, Topitriol

Calcitriol Chemical Structure

Molecular Weight(MW): 416.64

Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.

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In DMSO USD 500 In stock
USD 120 In stock
USD 270 In stock
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Cited by 9 Publications

3 Customer Reviews

  • Mireia Vila Gasull University of Porto. 2011;Mireia Vila Gasull . Calcitriol purchased from Selleck.

    To chemically induce klotho expression, THP-1 cells were treated with Calcitriol. The effects were evaluated on the gene level with real time PCR from 5 to 480 min after treatment and on the protein level with western blot after 48 h and 72 h.

    Mol Cell Endocrinol, 2018, 470:1-13. Calcitriol purchased from Selleck.

  • Calcitriol alleviates inflammation in vivo accompanied by upregulated A20. c HE staining, CD3+ lymphocyte and F4/80+ macrophage staining. Values are shown as mean ± SD, n = 5 per group. **P < 0.01 among groups. ΔΔP < 0.01 versus control.

    Inflammation, 2017, 40(6):1884-1893. Calcitriol purchased from Selleck.

Purity & Quality Control

Choose Selective Vitamin Inhibitors

Biological Activity

Description Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.
Targets
vitamin D receptor [1]
(Cell-free assay)
In vitro

Calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Calcitriol suppresses interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion. [1] Calcitriol increases the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol. [2] Calcitriol can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. Calcitriol causes a selective decrease in the secreted levels of type IV collagenases (MMP-2 and MMP-9). [3] Calcitriol has antiproliferative activity in squamous cell carcinoma and prostatic adenocarcinoma and enhances the antitumor activity of platinum-based agents. Calcitriol prior to paclitaxel significantly reduces clonogenic survival compared with either agent alone in the murine squamous cell carcinoma and PC-3 cells. [4] Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Calcitriol potentiates the antitumor effects of many cytotoxic agents and inhibits motility and invasiveness of tumor cells and formation of new blood vessels. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HCT116 NXyyVmM3S3m2b4TvfIlkyqCjc4PhfS=> M2Xsd|EzOCCq NG\meoVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBkd3WwdDDh[pRmeiBzMkCgbJJ{NCCLQ{WwQVFmNTB3IN88US=> M4XlPFIzQTJ4ME[4
human HOS cells NVvZe3RiTnWwY4Tpc44h[XO|YYm= MVSyOEBp NILGOXBC[3Srdnn0fUBifCCqdX3hckBXTFJiZYjwdoV{e2WmIHnuJIh2dWGwIFjPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIIDHUFMucE:lLDDwR2RPSS2qVlTSJIFv\CCyaGLMMXRMKGG|c3Xzd4VlKGG|IHHzd4V{e2WmIHHzJJRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJI1m[XO3cnXkJFI1KGi{czDwc5N1KGmwZnXjeIlwdiCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NYUuODVizszN Mmi5NlE5QDl|M{S=
human HOS/SF cells NXK1cm12TnWwY4Tpc44h[XO|YYm= MofjNlQhcA>? MmrkWJJidnOjY4TpeoF1cW:wIH;mJHZFWi2vZXTpZZRm\CCxc4Tlc4NidGOrbjDwdo9ud3SncjDpckBpfW2jbjDIU3MwW0ZiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0zNj[nLUC1JO69VQ>? NXrEW5BqOjR7MEC3Nlg>
human PBMC NWrveoo6TnWwY4Tpc44h[XO|YYm= NYnsenN6OjRiaB?= NFziR4JKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44hcW5iaIXtZY4hWEKPQzDh[pRmeiB{NDDodpMh[nliRVzJV2EtKEmFNU2yMllmNTB3IN88US=> NY\4W4tuOTl|MEmxOVU>
mouse LM05e cells MVzQdo9tcW[ncnH0bY9vKGG|c3H5 MknsO|IhcA>? MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEyPMEXlJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygcpVu[mW{IHHmeIVzKDd{IHjyd{BjgSCZU2SgZZN{[XluIFnDOVA:O2VvMEWg{txO NVrhUoFXOjR7MECzN|k>
rat osteosarcoma cells MlXtSpVv[3Srb36gZZN{[Xl? M1H6U2lv\HWldHnvckBw\iCYRGKtcYVlcWG2ZXSgNlQucHmmcn;4fYxie2VidILhcpNkemmydHnvckBqdiC{YYSgc5N1\W:|YYLjc41iKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWQ2OD1yLkKgcm0> MlzINlE6ODJ{M{W=
rat ROS 17/2.8 cells MXnGeY5kfGmxbjDhd5NigQ>? NF3sXmUyPiCq NVHubmRySWO2aY\peJkh[XRiVlTSJIlvKHKjdDDSU3MhOTdxMj64JINmdGy|IHHzd4V{e2WmIHHzJJRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJI9nKDJ2LXj5[JJwgHmuYYPlJIdmdmVicILvcY91\XJiYX\0[ZIhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkKgcm0> M3qzR|E6OTZ5OEmz
COS7 cells MXvGeY5kfGmxbjDhd5NigQ>? M{HjcVI1KGh? NHHYZYFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHZFWiCrbjDDU3M4KGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjD0doFve2O{aYD0bY9v[WxidILhcpNi[3SrdnH0bY9vKGGodHXyJFI1KGi{czDifUBud3W|ZTDvd5Rmd3CxboTpckBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC53IH7N NVny[3dOOTd7MESzO|A>
mouse SVEC cells NYTHWYxbWHKxbHnm[ZJifGmxbjDhd5NigQ>? MmPwO|IhcA>? MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKFOYRVOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDueY1j\XJiYX\0[ZIhPzJiaILzJIJ6KFeVVDDhd5NigSxiSVO1NF0xNjV{IH7N MXqyOFkxODN|OR?=
CV1 cells M{SyTWZ2dmO2aX;uJIF{e2G7 NWm0W4k5SWO2aY\peJkhd25iaIXtZY4hXkSULX3l[IlifGWmIITyZY5{[3KrcITpc44hd2Zib4P0[Y9k[WylaX6gWmRTTSCodYPl[EB1dyC2aIntbYRqdmVia3nuZZNmKHC{b33veIVzN2e{b4f0bEBpd3Kvb37lJJJmeG:{dHXyJIdmdmViaX6gR3YyKGOnbHzzMEBGTDVyPUCuO{BvVQ>? MmPxNVcyPDl6OEC=
COS1 cells MmHrSpVv[3Srb36gZZN{[Xl? NHfBclVFcXOybHHj[Y1mdnRib3[gNU1idHCqYTygNlUuME:KKWuzTH1FOyCocn;tJIh2dWGwIG\EVkBmgHC{ZYPz[YQhcW5iQ1;TNUBk\WyuczygTWM2OD1yLkigcm0> M2rqe|E4QTJ2NkG2
human PBMC MnjJSpVv[3Srb36gZZN{[Xl? Mmj2NlQhcA>? NWHiS5lkUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVDF{L{KzdFQxKHC{b3T1Z5Rqd25iaX6gbJVu[W5iUFLNR{Bi\nSncjCyOEBpenNiYomgSWxKW0FuIFnDOVA:OSCwTR?= NVLybphCOTl|MEmxOVU>
HEK293 cells NHSzTFlHfW6ldHnvckBie3OjeR?= MYOyOEBp NFO0d2FC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHZFWiCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJJRz[W6|Y4LpdJRqd26jbDD0doFve2GldHn2ZZRqd25iYX\0[ZIhOjRiaILzJIJ6KG2xdYPlJI9{fGWxcH;ueIlvKGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1zIH7N M4rIclE4QTB2M{ew
human HL60 cells NGHTNnRHfW6ldHnvckBie3OjeR?= MWnJcoR2[3Srb36gc4YhcHWvYX6gTGw3OCCmaX\m[ZJmdnSrYYTpc44h[XO|ZYPz[YQh[XNiY3XscJMhemWmdXPpcochdmm2cn:gZox2\SC2ZYTyZZpwdGm3bTygSWQ2OD1zIH7N NYrWcmhmOjF7MEKyN|U>
human HeLa cells M3nU[WZ2dmO2aX;uJIF{e2G7 MoPjNVYhcA>? M136WHRz[W6|YXP0bZZifGmxbjDv[kBISUx2LX\1d4VlKF[GUjDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1zIH7N NFzQcFMzOjl3N{izOC=>
human T47D cells NVjI[XFqWHKxbHnm[ZJifGmxbjDhd5NigQ>? MXK3NkBp NVvlXHA{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIFnfGW{IEeyJIhzeyCkeTDXV3Qh[XO|YYmsJGlEPTB;MT6zJI5O MYeyOFkxODN|OR?=
human peripheral blood mononuclear cells M1HpXnBzd2yrZnXyZZRqd25iYYPzZZk> NW\hRo12UW5idnn0do8hcW6qaXLpeIlwdiCxZjDwbJl1d2inbXHn[4x2fGmwaX7pck1qdmS3Y3XkJJN1cW23bHH0bY9vKG:oIHj1cYFvKHCncnnwbIVz[WxiYnzvc4QhdW:wb371Z4xm[XJiY3XscJMheHKxbHnm[ZJifGmxbjygSWQ2OD1{Lkegcm0> NV7iVVM5OTFyMECwNVQ>
human Caco-2 cells MlOxSpVv[3Srb36gZZN{[Xl? Mom2SYZn\WO2IH;uJHZFWiC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkhcW5iaIXtZY4hS2Glbz2yJINmdGy|IHnuJJBz\XOnbnPlJI9nKDVnIH\leIFtKGOjbH[gd4VzfW1uIFXDOVA:Oy53MjDuUS=> MmrGNVgxPTR{M{C=
human MCF7 cells MWHGeY5kfGmxbjDhd5NigQ>? NVTzU5ExSWexbnnzeEBi[3Srdnn0fUBifCC8ZXLyZYZqe2hiZ3HsOE1XTFJiTFLEJIV5eHKnc4Pl[EBqdiCqdX3hckBOS0Z5IHPlcIx{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:PS53IH7N NIjQfpIzOjF6MEizOy=>
human THP1 cells M4jsbWZ2dmO2aX;uJIF{e2G7 NIn5d4RC[3SrdnH0bY9vKG:oIG\EVkBqdiCqdX3hckBVUFBzIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJINifGinbHnjbYRqdiCjboTpcYlkem:kaXHsJJBmeHSrZHWgcXJPSSCneIDy[ZN{cW:wIHL5JHJVNVCFUjygSWM2OD1zMDDuUS=> M1XqOFE6OzB7MUW1
human HaCaT cells NITWXXpHfW6ldHnvckBie3OjeR?= M2DPPFI1KGh? NWXHPHc4XHKjboPhZ5RqfmG2aX;uJI9nKF[GUjDpckBpfW2jbjDIZWNiXCClZXzsd{Bi\nSncjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvOzJzNTFOwG0> NHi0SlMzPjN4N{CxPS=>
human HN12 cells NH7hRVVRem:uaX\ldoF1cW:wIHHzd4F6 NFjKTJU4OiCq NYPrUGRmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUlEzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIFnfGW{IEeyJIhzeyCkeTDXV3Qh[XO|YYmsJGlEPTB;MD61OVMh|ryP NV63fm95OjR7MECzN|k>
human HaCaT cells MYHGeY5kfGmxbjDhd5NigQ>? NF7lfItKdmirYnn0bY9vKG:oIHPvcI9vgSCob4LtZZRqd25ib3[gbJVu[W5iSHHDZXQh[2WubIO= NELsSXIzOjRyNEOyOi=>
human HCT116 cells MYDGeY5kfGmxbjDhd5NigQ>? NIHzc|EzOC12MDFOwG0> MUKyOEBp MmX5RYdwdmm|dDDhZ5Rqfmm2eTDheEBTSVJiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iSFPUNVE3KGOnbHzzJINwNWW6cILld5NqdmdiUlHSSUBifCB{MDD0c{A1OCC3TTDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NHzKSIEzOzJ5NkS0PS=>
mouse C3H10T1/2 cells NHHrWHVHfW6ldHnvckBie3OjeR?= NF\JV4oxNjVvNTFOwG0> MYOyOEBp MoTkTY5pcWKrdHnvckBw\iCKZXTn[Yhw\yC|aXfuZYxqdmdicHH0bJdigSCrbjDtc5V{\SCFM1ixNHQyNzJiY3XscJMh[XO|ZYPz[YQh[XNiZH;3ckBz\We3bHH0bY9vKG:oIFfsbVEh[XRiMD61JJRwKDVidV2gZYZ1\XJiMkSgbJJ{KGK7IGLUMXBEWiCjbnHsfZNqew>? MXiyNlIzPjZ3Nx?=
human A498 cells M3zBe2Z2dmO2aX;uJIF{e2G7 M360ZlAvODFizszN M2mwVFQhcA>? MmPOTY5lfWO2aX;uJI9nKEO\UEK0JI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDBOFk5KGOnbHzzJIF1KDBwMEGg{txOKGGodHXyJFQhcHK|IHL5JHJVNVCFUjDhcoFtgXOrcx?= NGOxNmgzOTN7Mkm4Ny=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (199.21 mM)
Ethanol 83 mg/mL (199.21 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 416.64
Formula

C27H44O3

CAS No. 32222-06-3
Storage powder
in solvent
Synonyms RO215535, Topitriol

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03563235 Not yet recruiting Postmenopausal Osteoporoses Fujian Academy of Traditional Chinese Medicine September 1 2019 Early Phase 1
NCT03563235 Not yet recruiting Postmenopausal Osteoporoses Fujian Academy of Traditional Chinese Medicine September 1 2019 Early Phase 1
NCT03748966 Recruiting X-linked Hypophosphatemia|Hypophosphatemic Rickets|Hypophosphatemic Rickets X-Linked Dominant Massachusetts General Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) December 1 2018 Early Phase 1
NCT03748966 Recruiting X-linked Hypophosphatemia|Hypophosphatemic Rickets|Hypophosphatemic Rickets X-Linked Dominant Massachusetts General Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) December 1 2018 Early Phase 1
NCT03249012 Recruiting Hypoparathyroidism Postprocedural|Quality of Life CHU de Quebec-Universite Laval September 1 2017 Not Applicable
NCT03249012 Recruiting Hypoparathyroidism Postprocedural|Quality of Life CHU de Quebec-Universite Laval September 1 2017 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID