Calcitriol

Catalog No.S1466 Synonyms: RO215535, Topitriol

Calcitriol Chemical Structure

Molecular Weight(MW): 416.64

Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.

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In DMSO USD 500 In stock
USD 120 In stock
USD 270 In stock
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Cited by 9 Publications

3 Customer Reviews

  • To chemically induce klotho expression, THP-1 cells were treated with Calcitriol. The effects were evaluated on the gene level with real time PCR from 5 to 480 min after treatment and on the protein level with western blot after 48 h and 72 h.

    Mol Cell Endocrinol, 2018, 470:1-13. Calcitriol purchased from Selleck.

    Calcitriol alleviates inflammation in vivo accompanied by upregulated A20. c HE staining, CD3+ lymphocyte and F4/80+ macrophage staining. Values are shown as mean ± SD, n = 5 per group. **P < 0.01 among groups. ΔΔP < 0.01 versus control.

    Inflammation, 2017, 40(6):1884-1893. Calcitriol purchased from Selleck.

  • Mireia Vila Gasull University of Porto. 2011;Mireia Vila Gasull . Calcitriol purchased from Selleck.

Purity & Quality Control

Choose Selective Vitamin Inhibitors

Biological Activity

Description Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.
Targets
vitamin D receptor [1]
(Cell-free assay)
In vitro

Calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Calcitriol suppresses interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion. [1] Calcitriol increases the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol. [2] Calcitriol can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. Calcitriol causes a selective decrease in the secreted levels of type IV collagenases (MMP-2 and MMP-9). [3] Calcitriol has antiproliferative activity in squamous cell carcinoma and prostatic adenocarcinoma and enhances the antitumor activity of platinum-based agents. Calcitriol prior to paclitaxel significantly reduces clonogenic survival compared with either agent alone in the murine squamous cell carcinoma and PC-3 cells. [4] Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Calcitriol potentiates the antitumor effects of many cytotoxic agents and inhibits motility and invasiveness of tumor cells and formation of new blood vessels. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HCT116 NYG2cY9vS3m2b4TvfIlkyqCjc4PhfS=> NHjkTpAyOjBiaB?= NV34c2NzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOWMUG2JIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwh[2:3boSgZYZ1\XJiMUKwJIhzeyxiSVO1NF0y\S1yNTFOwG0> MWWyNlkzPjB4OB?=
human HOS cells NIq4V4xHfW6ldHnvckBie3OjeR?= NIrXcYwzPCCq M2rUbGFkfGm4aYT5JIF1KGi3bXHuJHZFWiCneIDy[ZN{\WRiaX6gbJVu[W5iSF;TJINmdGy|IITyZY5{\mWldHXkJJdqfGhicFfMN{1pV2NuIIDDSG5CNWiYRGKgZY5lKHCqUlytWGsh[XO|ZYPz[YQh[XNiYYPz[ZN{\WRiYYOgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gcYVie3W{ZXSgNlQhcHK|IIDvd5QhcW6oZXP0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2x[U0xPSEQvF2= M360[lIyQDh7M{O0
human HOS/SF cells NEX6SXVHfW6ldHnvckBie3OjeR?= MXOyOEBp MnvLWJJidnOjY4TpeoF1cW:wIH;mJHZFWi2vZXTpZZRm\CCxc4Tlc4NidGOrbjDwdo9ud3SncjDpckBpfW2jbjDIU3MwW0ZiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0zNj[nLUC1JO69VQ>? M2nkUFI1QTByN{K4
human PBMC NFX6XndHfW6ldHnvckBie3OjeR?= NUjt[Wg5OjRiaB?= MX\Jcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSoFteGijIIDyc4R2[3Srb36gbY4hcHWvYX6gVGJOSyCjZoTldkAzPCCqcoOgZpkhTUyLU1GsJGlEPT1{LknlMVA2KM7:TR?= MX6xPVMxQTF3NR?=
mouse LM05e cells Mn;KVJJwdGmoZYLheIlwdiCjc4PhfS=> NITmWno4OiCq NFzVVXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFzNNFVmKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIFnfGW{IEeyJIhzeyCkeTDXV3Qh[XO|YYmsJGlEPTB;M3WtNFUh|ryP NIHhV3YzPDlyMEOzPS=>
rat osteosarcoma cells MYLGeY5kfGmxbjDhd5NigQ>? MmHMTY5lfWO2aX;uJI9nKF[GUj3t[YRq[XSnZDCyOE1pgWS{b4j5cIF{\SC2cnHud4NzcXC2aX;uJIlvKHKjdDDvd5Rmd3OjcnPvcYEh[2WubIOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFSFUxRTBwMjDuUS=> MnPNNlE6ODJ{M{W=
rat ROS 17/2.8 cells Mo\USpVv[3Srb36gZZN{[Xl? MoPyNVYhcA>? MYDBZ5Rqfmm2eTDheEBXTFJiaX6gdoF1KFKRUzCxO{8zNjhiY3XscJMh[XO|ZYPz[YQh[XNidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25ib3[gNlQucHmmcn;4fYxie2ViZ3Xu[UBxem:vb4TldkBi\nSncjCxOkBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvOiCwTR?= MUexPVE3Pzh7Mx?=
COS7 cells MnLRSpVv[3Srb36gZZN{[Xl? NXm0cIx3OjRiaB?= M4jHWGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gWmRTKGmwIFPPV|ch[2WubIOgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIITyZY5{[3KrcITpc45idCC2cnHud4FkfGm4YYTpc44h[W[2ZYKgNlQhcHK|IHL5JI1wfXOnIH;zeIVweG:wdHnuJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjVibl2= M3vw[|E4QTB2M{ew
mouse SVEC cells NVjpbGFuWHKxbHnm[ZJifGmxbjDhd5NigQ>? NWHKRoEyPzJiaB?= MlXrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCVVlXDJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygcpVu[mW{IHHmeIVzKDd{IHjyd{BjgSCZU2SgZZN{[XluIFnDOVA:OC53MjDuUS=> NXj3N4VrOjR7MECzN|k>
CV1 cells Mlf4SpVv[3Srb36gZZN{[Xl? NWPqbXlJSWO2aY\peJkhd25iaIXtZY4hXkSULX3l[IlifGWmIITyZY5{[3KrcITpc44hd2Zib4P0[Y9k[WylaX6gWmRTTSCodYPl[EB1dyC2aIntbYRqdmVia3nuZZNmKHC{b33veIVzN2e{b4f0bEBpd3Kvb37lJJJmeG:{dHXyJIdmdmViaX6gR3YyKGOnbHzzMEBGTDVyPUCuO{BvVQ>? MX:xO|E1QTh6MB?=
COS1 cells NVzHPY42TnWwY4Tpc44h[XO|YYm= MlPrSIl{eGyjY3Xt[Y51KG:oIEGtZYxxcGFuIEK1MUhQUCmdM1jdSFMh\nKxbTDoeY1idiCYRGKg[ZhxemW|c3XkJIlvKEORU{GgZ4VtdHNuIFnDOVA:OC56IH7N NWn4Ros{OTd7MkS2NVY>
human PBMC M3HyTWZ2dmO2aX;uJIF{e2G7 MXKyOEBp M4nqZmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgTWwyOi9{M4C0NEBxem:mdXP0bY9vKGmwIHj1cYFvKFCETVOgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCNCCLQ{WwQVEhdk1? NHrCOXMyQTNyOUG1OS=>
HEK293 cells NXPYUYxoTnWwY4Tpc44h[XO|YYm= NYrLdGVsOjRiaB?= MX3B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIG\EVkBqdiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIITyZY5{[3KrcITpc45idCC2cnHud4FkfGm4YYTpc44h[W[2ZYKgNlQhcHK|IHL5JI1wfXOnIH;zeIVweG:wdHnuJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0yKG6P NHK3eJcyPzlyNEO3NC=>
human HL60 cells M3XWXWZ2dmO2aX;uJIF{e2G7 NGjZdnZKdmS3Y4Tpc44hd2ZiaIXtZY4hUEx4MDDkbYZn\XKnboTpZZRqd25iYYPz[ZN{\WRiYYOgZ4VtdHNicnXkeYNqdmdibnn0do8h[my3ZTD0[ZRz[XqxbHn1cUwhTUR3ME2xJI5O MlfiNlE6ODJ{M{W=
human HeLa cells MnLySpVv[3Srb36gZZN{[Xl? NXTtS4lKOTZiaB?= NHLneG9VemGwc3HjeIl3[XSrb36gc4YhT0GOND3meZNm\CCYRGKgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDoeY1idiCKZVzhJINmdGy|IHHmeIVzKDF4IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MTDuUS=> NXLmfZJEOjJ7NUe4N|Q>
human T47D cells MWXQdo9tcW[ncnH0bY9vKGG|c3H5 MV63NkBp MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFR2N1SgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDueY1j\XJiYX\0[ZIhPzJiaILzJIJ6KFeVVDDhd5NigSxiSVO1NF0yNjNibl2= MlKyNlQ6ODB|M{m=
human peripheral blood mononuclear cells MYHQdo9tcW[ncnH0bY9vKGG|c3H5 NGLqXVBKdiC4aYTyc{BqdmirYnn0bY9vKG:oIIDofZRwcGWvYXfncJV1cW6rbnnuMYlv\HWlZXSgd5RqdXWuYYTpc44hd2ZiaIXtZY4heGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{Bxem:uaX\ldoF1cW:wLDDFSFUxRTJwNzDuUS=> MkfYNVExODByMUS=
human Caco-2 cells M{DYWGZ2dmO2aX;uJIF{e2G7 MkLuSYZn\WO2IH;uJHZFWiC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkhcW5iaIXtZY4hS2Glbz2yJINmdGy|IHnuJJBz\XOnbnPlJI9nKDVnIH\leIFtKGOjbH[gd4VzfW1uIFXDOVA:Oy53MjDuUS=> NFP1dIgyQDB3NEKzNC=>
human MCF7 cells M2jpUGZ2dmO2aX;uJIF{e2G7 NETLcJpC\2:waYP0JIFkfGm4aYT5JIF1KHqnYoLh[ol{cCCpYXy0MXZFWiCOQlSg[ZhxemW|c3XkJIlvKGi3bXHuJG1ETjdiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGKjc3XkJJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF02NjVibl2= NVHSSFg1OjJzOEC4N|c>
human THP1 cells MkDrSpVv[3Srb36gZZN{[Xl? NFW4SJVC[3SrdnH0bY9vKG:oIG\EVkBqdiCqdX3hckBVUFBzIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJINifGinbHnjbYRqdiCjboTpcYlkem:kaXHsJJBmeHSrZHWgcXJPSSCneIDy[ZN{cW:wIHL5JHJVNVCFUjygSWM2OD1zMDDuUS=> MkXmNVk{ODlzNUW=
human HaCaT cells MXXGeY5kfGmxbjDhd5NigQ>? MoX1NlQhcA>? M4TGc3Rz[W6|YXP0bZZifGmxbjDv[kBXTFJiaX6gbJVu[W5iSHHDZXQh[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlMzOTVizszN MUiyOlM3PzBzOR?=
human HN12 cells Mn\TVJJwdGmoZYLheIlwdiCjc4PhfS=> NWP0NWtSPzJiaB?= NHrVVY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjONVIh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBvfW2kZYKgZYZ1\XJiN{KgbJJ{KGK7IGfTWEBie3OjeTygTWM2OD1yLkW1N{DPxE1? NELVbowzPDlyMEOzPS=>
human HaCaT cells NHuxOFdHfW6ldHnvckBie3OjeR?= M4XNemlvcGmkaYTpc44hd2ZiY3;sc456KG[xcn3heIlwdiCxZjDoeY1idiCKYVPhWEBk\Wyucx?= MXuyNlQxPDN{Nh?=
human HCT116 cells Ml;qSpVv[3Srb36gZZN{[Xl? MV:yNE01OCEQvF2= MVGyOEBp M2PFWWFod26rc4SgZYN1cX[rdImgZZQhWkGUIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFjDWFEyPiClZXzsd{Bkdy2neIDy[ZN{cW6pIGLBVmUh[XRiMkCgeI8hPDBidV2gZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> M1LqS|I{Ojd4NES5
mouse C3H10T1/2 cells NGHnWINHfW6ldHnvckBie3OjeR?= M{T0NFAvPS13IN88US=> M2TtSlI1KGh? NHj4U41KdmirYnn0bY9vKG:oIFjl[IdmcG:pIIPp[45idGmwZzDwZZRpf2G7IHnuJI1wfXOnIFOzTFExXDFxMjDj[YxteyCjc4Pld5Nm\CCjczDkc5dvKHKnZ4XsZZRqd25ib3[gS4xqOSCjdDCwMlUhfG9iNTD1UUBi\nSncjCyOEBpenNiYomgVnQuWEOUIHHuZYx6e2m| M4DnTlIzOjJ4NkW3
human A498 cells NX:3PJZvTnWwY4Tpc44h[XO|YYm= Mo\UNE4xOSEQvF2= M2e0O|QhcA>? MknQTY5lfWO2aX;uJI9nKEO\UEK0JI1TVkFiZYjwdoV{e2mxbjDpckBpfW2jbjDBOFk5KGOnbHzzJIF1KDBwMEGg{txOKGGodHXyJFQhcHK|IHL5JHJVNVCFUjDhcoFtgXOrcx?= MnrWNlE{QTJ7OEO=

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Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (199.21 mM)
Ethanol 83 mg/mL (199.21 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 416.64
Formula

C27H44O3

CAS No. 32222-06-3
Storage powder
in solvent
Synonyms RO215535, Topitriol

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03563235 Not yet recruiting Postmenopausal Osteoporoses Fujian Academy of Traditional Chinese Medicine September 1 2019 Early Phase 1
NCT03563235 Not yet recruiting Postmenopausal Osteoporoses Fujian Academy of Traditional Chinese Medicine September 1 2019 Early Phase 1
NCT03748966 Recruiting X-linked Hypophosphatemia|Hypophosphatemic Rickets|Hypophosphatemic Rickets X-Linked Dominant Massachusetts General Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) December 1 2018 Early Phase 1
NCT03748966 Recruiting X-linked Hypophosphatemia|Hypophosphatemic Rickets|Hypophosphatemic Rickets X-Linked Dominant Massachusetts General Hospital|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) December 1 2018 Early Phase 1
NCT03249012 Recruiting Hypoparathyroidism Postprocedural|Quality of Life CHU de Quebec-Universite Laval September 1 2017 Not Applicable
NCT03249012 Recruiting Hypoparathyroidism Postprocedural|Quality of Life CHU de Quebec-Universite Laval September 1 2017 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID