Catalog No.S1466 Synonyms: RO215535, Topitriol
Molecular Weight(MW): 416.64
Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.
Cited by 10 Publications
3 Customer Reviews
Mireia Vila Gasull University of Porto. 2011;Mireia Vila Gasull . Calcitriol purchased from Selleck.
To chemically induce klotho expression, THP-1 cells were treated with Calcitriol. The effects were evaluated on the gene level with real time PCR from 5 to 480 min after treatment and on the protein level with western blot after 48 h and 72 h.
Mol Cell Endocrinol, 2018, 470:1-13. Calcitriol purchased from Selleck.
Calcitriol alleviates inflammation in vivo accompanied by upregulated A20. c HE staining, CD3+ lymphocyte and F4/80+ macrophage staining. Values are shown as mean ± SD, n = 5 per group. **P < 0.01 among groups. ΔΔP < 0.01 versus control.
Inflammation, 2017, 40(6):1884-1893. Calcitriol purchased from Selleck.
Purity & Quality Control
Choose Selective Vitamin Inhibitors
|Description||Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.|
Calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Calcitriol suppresses interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion.  Calcitriol increases the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol.  Calcitriol can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. Calcitriol causes a selective decrease in the secreted levels of type IV collagenases (MMP-2 and MMP-9).  Calcitriol has antiproliferative activity in squamous cell carcinoma and prostatic adenocarcinoma and enhances the antitumor activity of platinum-based agents. Calcitriol prior to paclitaxel significantly reduces clonogenic survival compared with either agent alone in the murine squamous cell carcinoma and PC-3 cells.  Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Calcitriol potentiates the antitumor effects of many cytotoxic agents and inhibits motility and invasiveness of tumor cells and formation of new blood vessels. 
-  Rigby WF, et al. J Clin Invest, 1984, 74(4), 1451-1455.
-  Le Mellay V, et al. J Biol Chem, 1997, 272(18), 11902-11907.
-  Schwartz GG, et al. Cancer Epidemiol Biomarkers Prev, 1997, 6(9), 727-732.
|In vitro||DMSO||83 mg/mL (199.21 mM)|
|Ethanol||83 mg/mL (199.21 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03029429||Recruiting||Drug: Theophylline|Drug: Placebos||Pseudohypoparathyroidism|Albright Hereditary Osteodystrophy||Vanderbilt University Medical Center|Harvard University||September 1 2018||Phase 2|
|NCT02714361||Completed||Dietary Supplement: Vitamin D3 supplement|Other: Placebo||Iron Deficiency|Anemia; Deficiency Nutritional With Poor Iron Absorption|Vitamin D Deficiency||University of Chester|Medical Research Council||September 2015||Not Applicable|
|NCT02332135||Unknown status||Procedure: microwave ablation|Drug: active vitamin D||Secondary Hyperparathyroidism|Maintenance Hemodialysis||Wenhu Liu|Beijing Friendship Hospital||January 2015||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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