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1-Cyclohexyl-3-dodecyl urea

Name: 1-Cyclohexyl-3-dodecyl urea
Brand: Selleck Chemicals
SKU: S0548
Rating: 5 (1 reviews)

Synonyms: CDU, N-Cyclohexyl-N-dodecyl urea, NCND

Catalog No.S0548 Purity: 99.55%

1-Cyclohexyl-3-dodecyl urea (CDU, N-Cyclohexyl-N-dodecyl urea, NCND) is a highly selective inhibitor of soluble epoxide hydrolase (sEH) that increases epoxyeicosatrienoic acids (EETs) levels.

1-Cyclohexyl-3-dodecyl urea Chemical Structure

CAS: 402939-18-8

Purity & Quality Control

Batch: S054801 Ethanol] 30 mg/mL] false] DMSO] Insoluble] false] Water] Insoluble] false Purity: 99.55%

99.55

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Choose Selective Epoxide Hydrolase Inhibitors

Biological Activity

Description

1-Cyclohexyl-3-dodecyl urea (CDU, N-Cyclohexyl-N-dodecyl urea, NCND) is a highly selective inhibitor of soluble epoxide hydrolase (sEH) that increases epoxyeicosatrienoic acids (EETs) levels.

Targets

sEH ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05413317	Recruiting	Pulmonary Embolism	Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer	March 4 2022	--
NCT05300139	Completed	Deep Vein Thrombosis	Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer	November 29 2021	--
NCT05687006	Completed	Mammaplasty	St. Anne''s University Hospital Brno Czech Republic\|Masaryk University	January 1 2021	Not Applicable
NCT04329182	Unknown status	Active Sacroiliitis in Ankylosing Spondylitis	Assiut University	May 2020	--
NCT03167333	Unknown status	Synovitis of Knee\|Osteoarthritis Knee	Taipei Veterans General Hospital Taiwan	March 1 2020	Not Applicable

References

[1] John D Imig, et al. Hypertension. 2002 Feb;39(2 Pt 2):690-4.

Chemical Information & Solubility

Molecular Weight	310.52	Formula	C₁₉H₃₈N₂O
CAS No.	402939-18-8	SDF	--
Smiles	CCCCCCCCCCCCNC(=O)NC1CCCCC1
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Ethanol : 30 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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