Home Metabolism Epoxide Hydrolase inhibitor 1-Cyclohexyl-3-dodecyl urea

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1-Cyclohexyl-3-dodecyl urea Epoxide Hydrolase inhibitor

Cat.No.S0548

1-Cyclohexyl-3-dodecyl urea (CDU, N-Cyclohexyl-N-dodecyl urea, NCND) is a highly selective inhibitor of soluble epoxide hydrolase (sEH) that increases epoxyeicosatrienoic acids (EETs) levels.
1-Cyclohexyl-3-dodecyl urea Epoxide Hydrolase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 310.52

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S054801 Ethanol]30 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 99.55%
99.55

Chemical Information, Storage & Stability

Molecular Weight 310.52 Formula

C19H38N2O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 402939-18-8 -- Storage of Stock Solutions

Synonyms CDU, N-Cyclohexyl-N-dodecyl urea, NCND Smiles CCCCCCCCCCCCNC(=O)NC1CCCCC1

Solubility

In vitro
Batch:

Ethanol : 30 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
sEH [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05413317 Completed
Pulmonary Embolism
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
 March 4 2022 --
NCT05300139 Completed
Deep Vein Thrombosis
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
 November 29 2021 --
NCT05687006 Completed
Mammaplasty
St. Anne''s University Hospital Brno Czech Republic|Masaryk University
 January 1 2021 Not Applicable
NCT04329182 Unknown status
Active Sacroiliitis in Ankylosing Spondylitis
Assiut University
 May 2020 --
NCT03167333 Unknown status
Synovitis of Knee|Osteoarthritis Knee
Taipei Veterans General Hospital Taiwan
 March 1 2020 Not Applicable

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