Home Protein Tyrosine Kinase CSF-1R inhibitor - Aurora Kinase inhibitor - VEGFR inhibitor - PDGFR inhibitor - c-Kit inhibitor Chiauranib For research use only.

Chiauranib

Synonyms: CS2164

Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.

Chiauranib Chemical Structure

Chiauranib Chemical Structure

CAS: 1256349-48-0

Purity & Quality Control

Batch: E061601 DMSO] 87 mg/mL] false] Ethanol] 10 mg/mL] false] Water] Insoluble] false Purity: 99.49%
99.49

Chiauranib Related Products

Signaling Pathway

CSF-1R Signaling Pathways

CSF-1R Signaling Pathway

Choose Selective CSF-1R Inhibitors

Biological Activity

Description Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
Targets
c-Kit [1]
(Kinase inhibition assay)		 VEGFR2 [1]
(Kinase inhibition assay)		 CSF-1R [1]
(Kinase inhibition assay)		 Aurora B [1]
(Kinase inhibition assay)
4 nM 7 nM 7 nM 9 nM

Chemical Information & Solubility

Molecular Weight 435.5 Formula

C27H21N3O3
CAS No. 1256349-48-0 SDF --
Smiles COC1=CC2=C(C=C1)C(=CC=N2)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=C(N)C=CC=C5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 87 mg/mL ( (199.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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