Home Cell Cycle Rho inhibitor CASIN For research use only.

CASIN

Synonyms: Pirl1-related Compound 2

CASIN (Pirl1-related Compound 2) directly inhibits activation of Cdc42/RhoGDI with IC50 of 2 μM.

CASIN Chemical Structure

CASIN Chemical Structure

CAS: 425399-05-9

Purity & Quality Control

Batch: S687501 DMSO] 61 mg/mL] false] Ethanol] 61 mg/mL] false] Water] Insoluble] false Purity: 99.92%
99.92

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Biological Activity

Description CASIN (Pirl1-related Compound 2) directly inhibits activation of Cdc42/RhoGDI with IC50 of 2 μM.
Targets
Cdc42/RhoGDI [1]
(Cell-free assay)
2 μM
In vitro
In vitro

CASIN facilitates the eradication of ALL LSCs by AraC + QC and prolongs the survival of both primary and secondary recipients without affecting long-term normal human hematopoiesis.[2]
Cell Research Cell lines Human ALL cell line Molt4-Luc2 expressing luciferase maker
Concentrations 5 μM
Incubation Time --
Method

For in vitro studies, CASIN (containing 0.02-0.2% DMSO) was used at 5 μM in the culture medium.
In Vivo
In vivo

The combination of CASIN with the AraC + QC regimen eliminates quiescent LSCs and prolongs the survival of xenografted mice.[2]
Animal Research Animal Models Humanized NSGS mice expressing transgenic cDNA encoding human SCF, GM-SCF, and IL-3 (NOD SCID IL-2Rγ -/- SCF, GM-CSF, and IL-3) 36
Dosages 2.4 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 306.4 Formula

C20H22N2O
CAS No. 425399-05-9 SDF --
Smiles OCCNC1CCCC2=C1[NH]C3=C2C=C(C=C3)C4=CC=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 61 mg/mL ( (199.08 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 61 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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