Home GPCR & G Protein Adrenergic Receptor agonist Clorprenaline HCl

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Clorprenaline HCl Adrenergic Receptor agonist

Cat.No.S4135

Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect.
Clorprenaline HCl Adrenergic Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 250.16

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Quality Control

Batch: S413501 DMSO]50 mg/mL]false]Water]50 mg/mL]false]Ethanol]50 mg/mL]false Purity: 99.91%
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99.91

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (199.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 50 mg/mL

Ethanol : 50 mg/mL

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 250.16 Formula

C11H16ClNO.HCl

 Storage (From the date of receipt)
CAS No. 6933-90-0 Download SDF Storage of Stock Solutions

Synonyms NSC 334693 Smiles CC(C)NCC(C1=CC=CC=C1Cl)O.Cl

Mechanism of Action

Targets/IC50/Ki
β2-receptor
In vitro
The linear ranges 8.0-1.6 ×103 ng/mL for Clorprenaline in a single chromatographic run, the detection limits 3.0 ng/mL for Clorprenaline. Clorprenaline is a bronchodilator that has been separated by CE based on affinity-interaction or with charged CD-CZE sulfobuthylether (SBE)-β-CD or β-CD-phosphate with resolution greater than 1.2. Clorprenaline is separated in optimum condition of 60 mM HP-β-CD. Clorprenaline hydrochloride (a), bromhexine hydrochloride (b) and decloxizine hydrochloride (c) are three main components in clorprenaline compound tablet.
References

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