Home Neuronal Signaling Adrenergic Receptor inhibitor Carvedilol Phosphate

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Carvedilol Phosphate Adrenergic Receptor inhibitor

Cat.No.S5703

Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
Carvedilol Phosphate Adrenergic Receptor inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 513.48

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S570301 DMSO]100 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 513.48 Formula

C24H29N2O8P.1/2H2O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 610309-89-2 -- Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.O.OP(=O)(O)O.OP(=O)(O)O

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (194.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00732511 Unknown status
Endothelial Function|Diabetes Mellitus|Hypertension
State University of New York - Downstate Medical Center
 April 2008 Phase 4
NCT00537043 Completed
Hypertension
GlaxoSmithKline
 October 2007 Phase 1
NCT00552708 Completed
Hypertension
GlaxoSmithKline
 September 2007 Phase 1
NCT00508365 Completed
Hypertension
GlaxoSmithKline
 September 25 2007 Phase 1

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