Ceftriaxone disodium salt hemi (heptahydrate)

For research use only.

Catalog No.S4158

1 publication

Ceftriaxone disodium salt hemi (heptahydrate) Chemical Structure

CAS No. 104376-79-6

Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.

Selleck's Ceftriaxone disodium salt hemi (heptahydrate) has been cited by 1 publication

Purity & Quality Control

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Biological Activity

Description Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.
In vitro

Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic has a broad spectrum of activity in vitro which includes Gram-positive and Gram-negative aerobic and some anaerobic bacteria. Both penicillin-sensitive and –resistant strains of Staphyococcus aureus are sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug is poorly active against methicillin- or oxacillin-resistant strains. Creftriaxone is similar in activity to several penicillins and other cephalosporins against Streptococcus pyogenes, and is also active in low concentrations against other Streptococcus species. Staphylococcus epidermidis is only moderately sensitive and Streptococcus faecalis is usually resistant to Ceftriaxone. Ceftriaxone is generally more active than cefoperazone, and is similar in activity to cefotaxime and latamoxef against Gram-negative bacilli. 90% of tested strains of most Enterobacteroacae are inhibited by a Ceftriaxone concentration of < 1 mg/L. The reported activity of Ceftriaxone against Pseudomonas aeruginosa varies widely, but generally at least 32 mg/L is required to inhibit most strains, and is thus usually less active than the aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime, carumonam and piperacillin. and several species of Bacteroides, including B. fragilis, are only moderately sensitive or insensitive to Ceftriaxone, but some other anaerobic bacteria are inhibited by the drug. Ceftriaxone is stable to inactivation by β-lactamases produced by many bacteria, but not to those produced by B. fragilis or by some strains of Klebsiella species, Proteus vulgaris and Pseudomonas cepacia. In general, theβ-lactamase stability of Ceftriaxone is similar to that of cefotaxime and cefuroxime. [1]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (151.14 mM)
DMSO 1 mg/mL (1.51 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 661.6
Formula

C18H16N8O7S3.7/2H2O.2Na

CAS No. 104376-79-6
Storage powder
in solvent
Synonyms N/A
Smiles CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04902560 Recruiting -- Gonorrhea University Hospital Montpellier May 1 2021 --
NCT04269434 Active not recruiting Other: No Screening Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis Infection Institute of Tropical Medicine Belgium September 21 2020 Not Applicable
NCT04268342 Not yet recruiting Other: Resistance guided treatment for gonorrhoea infection Drug Resistance Microbial|Antimicrobial Stewardship|Gonorrhea The University of Queensland|Kirby Institute|Monash University|South Australian Health and Medical Research Institute|University of Melbourne|University of California Los Angeles|Griffith University|Queensland Health|SydPath - St Vincent''s Pathology|SpeeDx Pty. Ltd.|NSW Health Pathology|University of Sydney March 2 2020 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID