Ceftriaxone disodium salt hemi(heptahydrate)
Molecular Weight(MW): 661.6
Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic.
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|Description||Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic.|
Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic has a broad spectrum of activity in vitro which includes Gram-positive and Gram-negative aerobic and some anaerobic bacteria. Both penicillin-sensitive and –resistant strains of Staphyococcus aureus are sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug is poorly active against methicillin- or oxacillin-resistant strains. Creftriaxone is similar in activity to several penicillins and other cephalosporins against Streptococcus pyogenes, and is also active in low concentrations against other Streptococcus species. Staphylococcus epidermidis is only moderately sensitive and Streptococcus faecalis is usually resistant to Ceftriaxone. Ceftriaxone is generally more active than cefoperazone, and is similar in activity to cefotaxime and latamoxef against Gram-negative bacilli. 90% of tested strains of most Enterobacteroacae are inhibited by a Ceftriaxone concentration of < 1 mg/L. The reported activity of Ceftriaxone against Pseudomonas aeruginosa varies widely, but generally at least 32 mg/L is required to inhibit most strains, and is thus usually less active than the aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime, carumonam and piperacillin.
|In vitro||Water||100 mg/mL (151.14 mM)|
|DMSO||1 mg/mL (1.51 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03959527||Recruiting||Drug: zoliflodacin|Drug: ceftriaxone|Drug: azithromycin||Gonorrhea||Global Antibiotics Research and Development Partnership||September 27 2019||Phase 3|
|NCT03179384||Recruiting||Drug: Ceftriaxone||Pyelonephritis Acute||Centre Hospitalier Universitaire de Nice||June 26 2017||Phase 4|
|NCT02746276||Unknown status||Drug: Ceftriaxone|Drug: Metronidazole||Malnutrition||University of Oxford|KEMRI-Wellcome Trust Collaborative Research Program|Centre for Research in Therapeutic Sciences Strathmore University Nairobi Kenya|University College London|Centre for Microbiology Research Kenya Medical Research Institute|Centre for Clinical Research Kenya Medical Research Institute||April 1 2016||Phase 2|
|NCT02473640||Completed||Drug: SYN-004|Drug: Esomeprazole|Drug: Ceftriaxone||Healthy Volunteers With Ileostomy||Synthetic Biologics Inc.||June 2015||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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