Ceftriaxone disodium salt hemi(heptahydrate)

Catalog No.S4158

Ceftriaxone disodium salt hemi(heptahydrate) Chemical Structure

Molecular Weight(MW): 661.6

Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic.

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Biological Activity

Description Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic.
In vitro

Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic has a broad spectrum of activity in vitro which includes Gram-positive and Gram-negative aerobic and some anaerobic bacteria. Both penicillin-sensitive and –resistant strains of Staphyococcus aureus are sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug is poorly active against methicillin- or oxacillin-resistant strains. Creftriaxone is similar in activity to several penicillins and other cephalosporins against Streptococcus pyogenes, and is also active in low concentrations against other Streptococcus species. Staphylococcus epidermidis is only moderately sensitive and Streptococcus faecalis is usually resistant to Ceftriaxone. Ceftriaxone is generally more active than cefoperazone, and is similar in activity to cefotaxime and latamoxef against Gram-negative bacilli. 90% of tested strains of most Enterobacteroacae are inhibited by a Ceftriaxone concentration of < 1 mg/L. The reported activity of Ceftriaxone against Pseudomonas aeruginosa varies widely, but generally at least 32 mg/L is required to inhibit most strains, and is thus usually less active than the aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime, carumonam and piperacillin. and several species of Bacteroides, including B. fragilis, are only moderately sensitive or insensitive to Ceftriaxone, but some other anaerobic bacteria are inhibited by the drug. Ceftriaxone is stable to inactivation by β-lactamases produced by many bacteria, but not to those produced by B. fragilis or by some strains of Klebsiella species, Proteus vulgaris and Pseudomonas cepacia. In general, theβ-lactamase stability of Ceftriaxone is similar to that of cefotaxime and cefuroxime. [1]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (151.14 mM)
DMSO 1 mg/mL (1.51 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 661.6
Formula

C18H16N8O7S3.7/2H2O.2Na

CAS No. 104376-79-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03959527 Recruiting Drug: zoliflodacin|Drug: ceftriaxone|Drug: azithromycin Gonorrhea Global Antibiotics Research and Development Partnership September 27 2019 Phase 3
NCT03179384 Recruiting Drug: Ceftriaxone Pyelonephritis Acute Centre Hospitalier Universitaire de Nice June 26 2017 Phase 4
NCT02746276 Unknown status Drug: Ceftriaxone|Drug: Metronidazole Malnutrition University of Oxford|KEMRI-Wellcome Trust Collaborative Research Program|Centre for Research in Therapeutic Sciences Strathmore University Nairobi Kenya|University College London|Centre for Microbiology Research Kenya Medical Research Institute|Centre for Clinical Research Kenya Medical Research Institute April 1 2016 Phase 2
NCT02473640 Completed Drug: SYN-004|Drug: Esomeprazole|Drug: Ceftriaxone Healthy Volunteers With Ileostomy Synthetic Biologics Inc. June 2015 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID