Home Microbiology Antibiotics chemical Ceftriaxone disodium salt hemi (heptahydrate)

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Ceftriaxone disodium salt hemi (heptahydrate) Antibiotics chemical

Cat.No.S4158

Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.
Ceftriaxone disodium salt hemi (heptahydrate) Antibiotics chemical Chemical Structure

Chemical Structure

Molecular Weight: 661.6

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Quality Control

Batch: S415801 Water]100 mg/mL]false]DMSO]1 mg/mL]false]Ethanol]Insoluble]false Purity: 99.06%
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99.06

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : 1 mg/mL (1.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 661.6 Formula

C18H16N8O7S3.7/2H2O.2Na

 Storage (From the date of receipt)
CAS No. 104376-79-6 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

Mechanism of Action

In vitro

Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic has a broad spectrum of activity in vitro which includes Gram-positive and Gram-negative aerobic and some anaerobic bacteria. Both penicillin-sensitive and –resistant strains of Staphyococcus aureus are sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug is poorly active against methicillin- or oxacillin-resistant strains. Creftriaxone is similar in activity to several penicillins and other cephalosporins against Streptococcus pyogenes, and is also active in low concentrations against other Streptococcus species. Staphylococcus epidermidis is only moderately sensitive and Streptococcus faecalis is usually resistant to Ceftriaxone. Ceftriaxone is generally more active than cefoperazone, and is similar in activity to cefotaxime and latamoxef against Gram-negative bacilli. 90% of tested strains of most Enterobacteroacae are inhibited by a Ceftriaxone concentration of < 1 mg/L. The reported activity of Ceftriaxone against Pseudomonas aeruginosa varies widely, but generally at least 32 mg/L is required to inhibit most strains, and is thus usually less active than the aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime, carumonam and piperacillin. and several species of Bacteroides, including B. fragilis, are only moderately sensitive or insensitive to Ceftriaxone, but some other anaerobic bacteria are inhibited by the drug. Ceftriaxone is stable to inactivation by β-lactamases produced by many bacteria, but not to those produced by B. fragilis or by some strains of Klebsiella species, Proteus vulgaris and Pseudomonas cepacia. In general, theβ-lactamase stability of Ceftriaxone is similar to that of cefotaxime and cefuroxime.

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05960006 Recruiting
Antibiotic Toxicity|Liver Cirrhosis|Renal Insufficiency|Ceftriaxone Overdose|Ascites Hepatic|Infection Bacterial
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Erasmus Medical Center
 July 10 2023 --
NCT04268342 Active not recruiting
Drug Resistance Microbial|Antimicrobial Stewardship|Gonorrhea
The University of Queensland|Kirby Institute|Monash University|South Australian Health and Medical Research Institute|University of Melbourne|University of California Los Angeles|Griffith University|Queensland Health|St Vincent''s Hospital Sydney|SpeeDx Pty Ltd|NSW Health Pathology|University of Sydney
 April 26 2022 Not Applicable
NCT04902560 Completed
Gonorrhea
University Hospital Montpellier
 May 1 2021 --
NCT05061875 Unknown status
Ceftriaxone Poisoning
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
 March 1 2021 --

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