Ceftriaxone disodium salt hemi (heptahydrate)

Catalog No.S4158

For research use only.

Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.

Ceftriaxone disodium salt hemi (heptahydrate) Chemical Structure

CAS No. 104376-79-6

Selleck's Ceftriaxone disodium salt hemi (heptahydrate) has been cited by 1 Publication

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Biological Activity

Description Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.
In vitro

Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic has a broad spectrum of activity in vitro which includes Gram-positive and Gram-negative aerobic and some anaerobic bacteria. Both penicillin-sensitive and –resistant strains of Staphyococcus aureus are sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug is poorly active against methicillin- or oxacillin-resistant strains. Creftriaxone is similar in activity to several penicillins and other cephalosporins against Streptococcus pyogenes, and is also active in low concentrations against other Streptococcus species. Staphylococcus epidermidis is only moderately sensitive and Streptococcus faecalis is usually resistant to Ceftriaxone. Ceftriaxone is generally more active than cefoperazone, and is similar in activity to cefotaxime and latamoxef against Gram-negative bacilli. 90% of tested strains of most Enterobacteroacae are inhibited by a Ceftriaxone concentration of < 1 mg/L. The reported activity of Ceftriaxone against Pseudomonas aeruginosa varies widely, but generally at least 32 mg/L is required to inhibit most strains, and is thus usually less active than the aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime, carumonam and piperacillin. and several species of Bacteroides, including B. fragilis, are only moderately sensitive or insensitive to Ceftriaxone, but some other anaerobic bacteria are inhibited by the drug. Ceftriaxone is stable to inactivation by β-lactamases produced by many bacteria, but not to those produced by B. fragilis or by some strains of Klebsiella species, Proteus vulgaris and Pseudomonas cepacia. In general, theβ-lactamase stability of Ceftriaxone is similar to that of cefotaxime and cefuroxime. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 661.6
Formula

C18H16N8O7S3.7/2H2O.2Na

CAS No. 104376-79-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04902560 Completed -- Gonorrhea University Hospital Montpellier May 1 2021 --
NCT05061875 Recruiting -- Ceftriaxone Poisoning Fundación Pública Andaluza para la gestión de la Investigación en Sevilla March 1 2021 --
NCT04269434 Active not recruiting Other: No Screening Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis Infection Institute of Tropical Medicine Belgium September 21 2020 Not Applicable
NCT04268342 Unknown status Other: Resistance guided treatment for gonorrhoea infection Drug Resistance Microbial|Antimicrobial Stewardship|Gonorrhea The University of Queensland|Kirby Institute|Monash University|South Australian Health and Medical Research Institute|University of Melbourne|University of California Los Angeles|Griffith University|Queensland Health|SydPath - St Vincent''s Pathology|SpeeDx Pty. Ltd.|NSW Health Pathology|University of Sydney March 2 2020 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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