Ceftriaxone disodium salt hemi (heptahydrate)
For research use only.
CAS No. 104376-79-6
Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.
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|Description||Ceftriaxone disodium salt hemi (heptahydrate) is a third-generation cephalosporin antibiotic.|
Ceftriaxone disodium salt hemi(heptahydrate) is a third-generation cephalosporin antibiotic has a broad spectrum of activity in vitro which includes Gram-positive and Gram-negative aerobic and some anaerobic bacteria. Both penicillin-sensitive and –resistant strains of Staphyococcus aureus are sensitive to Ceftriaxone (MIC90, 2 to 8 mg/L), but the drug is poorly active against methicillin- or oxacillin-resistant strains. Creftriaxone is similar in activity to several penicillins and other cephalosporins against Streptococcus pyogenes, and is also active in low concentrations against other Streptococcus species. Staphylococcus epidermidis is only moderately sensitive and Streptococcus faecalis is usually resistant to Ceftriaxone. Ceftriaxone is generally more active than cefoperazone, and is similar in activity to cefotaxime and latamoxef against Gram-negative bacilli. 90% of tested strains of most Enterobacteroacae are inhibited by a Ceftriaxone concentration of < 1 mg/L. The reported activity of Ceftriaxone against Pseudomonas aeruginosa varies widely, but generally at least 32 mg/L is required to inhibit most strains, and is thus usually less active than the aminoglycosides, aztreonam, imipenem, cefoperazone, ceftazidime, carumonam and piperacillin.
|In vitro||Water||100 mg/mL (151.14 mM)|
|DMSO||1 mg/mL (1.51 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04902560||Recruiting||--||Gonorrhea||University Hospital Montpellier||May 1 2021||--|
|NCT04269434||Active not recruiting||Other: No Screening||Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis Infection||Institute of Tropical Medicine Belgium||September 21 2020||Not Applicable|
|NCT04268342||Not yet recruiting||Other: Resistance guided treatment for gonorrhoea infection||Drug Resistance Microbial|Antimicrobial Stewardship|Gonorrhea||The University of Queensland|Kirby Institute|Monash University|South Australian Health and Medical Research Institute|University of Melbourne|University of California Los Angeles|Griffith University|Queensland Health|SydPath - St Vincent''s Pathology|SpeeDx Pty. Ltd.|NSW Health Pathology|University of Sydney||March 2 2020||Not Applicable|
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