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Caffeic Acid Phenethyl Ester
Catalog No.S7414 Synonyms: CAPE, Phenylethyl Caffeate
For research use only.
Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.
CAS No. 104594-70-9
Selleck's Caffeic Acid Phenethyl Ester has been cited by 40 publications
Purity & Quality Control
Choose Selective NF-κB Inhibitors
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Biological Activity
| Description | Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
Caffeic acid phenethyl ester blocks NF-κB activation induced by phorbol ester, ceramide, okadaic acid, and hydrogen peroxide by preventing the translocation of the p65 subunit of NF-κB to the nucleus. [1] In a series of tumor cell lines, Caffeic acid phenethyl ester shows promising antiproliferative activity with EC50 of 1.76, 3.16, 13.7, and 44.0 μM against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines, respectively. [2] Caffeic acid phenethyl ester, as a potent antioxidant, exerts its anti-apoptotic effect in cerebellar granule cells by blocking ROS formation and inhibiting caspase activity. [3] Moreover, Caffeic acid phenethyl ester attenuates the pro-inflammatory phenotype of LPS-stimulated HSCs, and LPS-induced sensitization of HSCs to fibrogenic cytokines by inhibiting NF-κB signaling. [4] |
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| Cell Data |
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| Assay |
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| In vivo | In vivo, Caffeic acid phenethyl ester (10 mg/kg, i.p.) inhibits the growth and angiogenesis of primary tumors in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. [5] Caffeic acid phenethyl ester (5, 10, 20 mg/kg) also shows immunomodulatory effects in vivo by decreasing thymus weight and/or cellularity of thymus and spleen. [6] |
Protocol (from reference)
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Solubility (25°C)
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In vitro |
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Chemical Information
| Molecular Weight | 284.31 | ||
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| Formula | C17H16O4 |
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| CAS No. | 104594-70-9 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | C1=CC=C(C=C1)CCOC(=O)C=CC2=CC(=C(C=C2)O)O | ||
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.
Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT05157828 | Not yet recruiting | Other: No intervention | Iron Deficiency Anemia of Pregnancy | University of Cape Town | February 2022 | -- |
| NCT04633434 | Not yet recruiting | Device: The Talk Parenting Skill for Alexa | Parenting Practices|Self Efficacy|Stress|Child Behavior|Emotional Adjustment|Sleep Problems|Parent-Child Relations | Oregon Research Behavioral Intervention Strategies Inc.|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | September 1 2021 | Not Applicable |
| NCT05110417 | Recruiting | Drug: Pyridostigmine Bromide 60 Milligrams (mg) | Dysphonia Spastic|Dysphonia|Laryngeal Dystonia | Eastern Virginia Medical School | May 20 2021 | Phase 4 |
| NCT04028674 | Enrolling by invitation | Device: Laryngeal Pacing Device | Bilateral Vocal Fold Paralysis (BVFP) | Vanderbilt University Medical Center|National Institute on Deafness and Other Communication Disorders (NIDCD) | January 14 2021 | Not Applicable |
| NCT04633473 | Recruiting | Behavioral: SIB-Time Web-Application Tool | Family Relations|Sibling Relations | Oregon Research Behavioral Intervention Strategies Inc. | January 1 2021 | Not Applicable |
| NCT03790956 | Recruiting | Procedure: Silk Microparticle Filler Injection | Vocal Cord Paralysis Unilateral|Dysphonia|Dysphagia Oropharyngeal | University of Southern California|Sofregen Medical Inc. | July 1 2020 | Not Applicable |
(data from https://clinicaltrials.gov, updated on 2022-01-17)
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