Caffeic Acid Phenethyl Ester
For research use only.
Catalog No.S7414 Synonyms: CAPE, Phenylethyl Caffeate
CAS No. 104594-70-9
Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.
Selleck's Caffeic Acid Phenethyl Ester has been cited by 36 publications
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Choose Selective NF-κB Inhibitors
|Description||Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.|
Caffeic acid phenethyl ester blocks NF-κB activation induced by phorbol ester, ceramide, okadaic acid, and hydrogen peroxide by preventing the translocation of the p65 subunit of NF-κB to the nucleus.  In a series of tumor cell lines, Caffeic acid phenethyl ester shows promising antiproliferative activity with EC50 of 1.76, 3.16, 13.7, and 44.0 μM against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines, respectively.  Caffeic acid phenethyl ester, as a potent antioxidant, exerts its anti-apoptotic effect in cerebellar granule cells by blocking ROS formation and inhibiting caspase activity.  Moreover, Caffeic acid phenethyl ester attenuates the pro-inflammatory phenotype of LPS-stimulated HSCs, and LPS-induced sensitization of HSCs to fibrogenic cytokines by inhibiting NF-κB signaling. 
|In vivo||In vivo, Caffeic acid phenethyl ester (10 mg/kg, i.p.) inhibits the growth and angiogenesis of primary tumors in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells.  Caffeic acid phenethyl ester (5, 10, 20 mg/kg) also shows immunomodulatory effects in vivo by decreasing thymus weight and/or cellularity of thymus and spleen. |
-  Natarajan K, et al. Proc Natl Acad Sci U S A. 1996, 93(17), 9090-9095.
-  Banskota AH, et al. J Ethnopharmacol. 2002, 80(1), 67-73.
-  Amodio R, et al. Int J Dev Neurosci. 2003, 21(7), 379-389.
|In vitro||DMSO||57 mg/mL (200.48 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||CAPE, Phenylethyl Caffeate|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04633434||Not yet recruiting||Device: The Talk Parenting Skill for Alexa||Parenting Practices|Self Efficacy|Stress|Child Behavior|Emotional Adjustment|Sleep Problems|Parent-Child Relations||Oregon Research Behavioral Intervention Strategies Inc.|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)||September 1 2021||Not Applicable|
|NCT04028674||Enrolling by invitation||Device: Laryngeal Pacing Device||Bilateral Vocal Fold Paralysis (BVFP)||Vanderbilt University Medical Center|National Institute on Deafness and Other Communication Disorders (NIDCD)||January 14 2021||Not Applicable|
|NCT04633473||Recruiting||Behavioral: SIB-Time Web-Application Tool||Family Relations|Sibling Relations||Oregon Research Behavioral Intervention Strategies Inc.||January 1 2021||Not Applicable|
|NCT03790956||Recruiting||Procedure: Silk Microparticle Filler Injection||Vocal Cord Paralysis Unilateral|Dysphonia|Dysphagia Oropharyngeal||University of Southern California|Sofregen Medical Inc.||July 1 2020||Not Applicable|
|NCT03749863||Enrolling by invitation||Procedure: Serial PRP injections||Presbylarynx|Atrophy; Larynx|Dysphonia|Vocal Cord Atrophy|Presbylarynges|Vocal Fold Scar|Sulcus Vocalis of Vocal Cord||University of Southern California||February 18 2020||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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