Home Immunology & Inflammation CCR antagonist C-021 For research use only.

C-021

C-021 is a potent CCR4 antagonist with IC50 values are 0.14 μM and 39 nM for inhibition of chemotaxis in human and mouse respectively.

C-021 Chemical Structure

C-021 Chemical Structure

CAS: 864289-85-0

Purity & Quality Control

Batch: E048601 DMSO] 94 mg/mL] false] Ethanol] 23 mg/mL] false] Water] Insoluble] false Purity: 99.98%
99.98

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Biological Activity

Description C-021 is a potent CCR4 antagonist with IC50 values are 0.14 μM and 39 nM for inhibition of chemotaxis in human and mouse respectively.
Targets
CCR4 [1]
(in the [35S]GTPγS-binding and mouse chemotaxis assay)		 CCR4 [1]
(in the [35S]GTPγS-binding and human chemotaxis assay)
39 nM 0.14 μM
In Vivo
In vivo

C021 is a potent CC chemokine receptor-4 (CCR4) antagonist, which significantly reduces microglia activation and phosphorylation of ERK1/2, also alleviates AOM-induced cytokine upregulation in azoxymethane (AOM)-treated mice.[2]
Animal Research Animal Models Mouse model of hepatic encephalopathy
Dosages 1 mg/kg/day
Administration i.p.

Chemical Information & Solubility

Molecular Weight 467.65 Formula

C27H41N5O2
CAS No. 864289-85-0 SDF --
Smiles COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCCCCC3)N4CCC(CC4)N5CCCCC5
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 94 mg/mL ( (201.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 23 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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