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Cyromazine Parasite inhibitor

Cat.No.S4167

Cyromazine(Cyromazin,CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide.
Cyromazine Parasite inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 166.18

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Quality Control

Batch: S416701 DMSO]33 mg/mL]false]Ethanol]2 mg/mL]false]Water]1 mg/mL]false Purity: 99.2%
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99.2

Solubility

In vitro
Batch:

DMSO : 33 mg/mL (198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 2 mg/mL

Water : 1 mg/mL

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 166.18 Formula

C6H10N6

 Storage (From the date of receipt)
CAS No. 66215-27-8 Download SDF Storage of Stock Solutions

Synonyms Cyromazin,CGA-72662 Smiles C1CC1NC2=NC(=NC(=N2)N)N

Mechanism of Action

In vitro

Cyromazine, a cyclopropyl derivative of melamine, is an insect growth regulator, affects larval and pupal cuticles in dipterans and some other insects. The mode of action of this compound may be to inhibit the synthesis of chitin and cuticular proteins. It may, however, act on some step(s) of sclerotization of the cuticle. This chemical does not significantly affect PAH and DHFR activity. It changes the relative content of phenylalanine and tyrosine, or the total amount and profile of amino acids of puparial cuticles, which showed a larviform shape typical for cyromazine intoxication.

In vivo

Cyromazine can be hydrolysed at extreme pH or photodegraded leading to the stable heterocyclic structure melamine (1,3,5-triazine-2,4,6-triamine). It can also be metabolized via dealkylation reactions in both plants and animals and undergoes environmental degradation to form melamin.

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