CD38 inhibitor 1 (compound 78c)

Catalog No.S8960 Synonyms: CD38-IN-78c, MDK-7553

For research use only.

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

CD38 inhibitor 1 (compound 78c) Chemical Structure

CAS No. 1700637-55-3

Selleck's CD38 inhibitor 1 (compound 78c) has been cited by 1 Publication

Purity & Quality Control

Choose Selective CD markers Inhibitors

Biological Activity

Description CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.
Targets
mCD38 [1]
(Cell-free assay)
hCD38 [1]
(Cell-free assay)
1.9 nM 7.3 nM
In vitro

CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs.[2]

In vivo

CD38 inhibitor 1 (compound 78c) is found to not only be a very potent inhibitor, but also had suitable physiochemical properties to serve as a robust tool for in vivo studies. In addition, CD38 inhibitor 1 (compound 78c) is able to elevate NAD in both liver and gastrocnemius tissue when dosed orally in a DIO mouse.[1]

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: HEK293T, MEFs, A549, Jurkat T and AML12 cells
  • Concentrations: 0.5 μM, 0.2 - 0.5 μM
  • Incubation Time: 16 h, 24 h
  • Method:

    To test the reversibility of the CD38i, A549 cells were treated with vehicle or 0.5 μM 78c for 16 hours. Then, cells were washed and incubated with (78c) or without (78c+release) 78c for another 8 hours.

Animal Research:

[1]

  • Animal Models: DIO C57Bl6 mice
  • Dosages: 30 mg/kg, 2 mg/kg
  • Administration: Oral gavage, IV

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 413.53
Formula

C22H27N3O3S

CAS No. 1700637-55-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy CD38 inhibitor 1 (compound 78c) | CD38 inhibitor 1 (compound 78c) supplier | purchase CD38 inhibitor 1 (compound 78c) | CD38 inhibitor 1 (compound 78c) cost | CD38 inhibitor 1 (compound 78c) manufacturer | order CD38 inhibitor 1 (compound 78c) | CD38 inhibitor 1 (compound 78c) distributor