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CD38 inhibitor 1 (compound 78c) CD38 inhibitor

Name: CD38 inhibitor 1 (compound 78c)
SKU: S8960
Availability: InStock
Rating: 5 (7 reviews)

Cat.No.S8960

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

Chemical Structure

Molecular Weight: 413.53

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.98%

99.98

Products Often Used Together with CD38 inhibitor 1 (compound 78c)

Quercetin (Sophoretin)

It and Quercetin use decreases lipopolysaccharides (LPS), inflammation, and CD38 levels and helps to prevent aging and metabolic disorders.

Apigenin

It and Apigenin enhance NAD+ levels and SIRT1 activity by inhibiting CD38.

Tectochrysin

Tectochrysin has high binding affinity for CD38, similar to that of the endogenous inhibitor of this enzyme.

Chrysin

Chrysin has high binding affinity for CD38, similar to the endogenous inhibitor of CD38 which was revealed by molecular docking.

Related Targets	AChR Calcium Channel Sodium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR NMDAR P2 Receptor Proton Pump P-gp CFTR SGLT Chloride Channel MCT Amino acid transporter GLUT CRM1 VDAC BCRP NKCC OCT NCX OAT VMAT Aquaporin EAAT GlyT GlyR
Related Products	Anti-CD83 SodiuM Metatungstate NQ301 LY-3475070 Relatlimab (anti-LAG-3) Apamistamab (Anti-PTPRC / CD45) Dalotuzumab (Anti-IGF1R / CD221) E-Cadherin Antibody [P11M9] Neihulizumab (Anti-PSGL1 / CD162) Visilizumab (Anti-CD3) Anti-CD34 Tregalizumab (Anti-CD4) Anti-CD4 (TRX1) Anti-F3 / Factor III / Tissue Factor / CD142 (TNX-832) NCAM1 Antibody [G16N2] Divozilimab (Anti-CD20) Letaplimab (Anti-CD47) Ligufalimab (Anti-CD47) Urabrelimab (Anti-CD47) Anti-TNFRSF4 / OX40 / CD134 (BMS-986178) CD9 Antibody [J21F10] Gatralimab (Anti-CD52) CD147 Antibody [C22F12] Mupadolimab (Anti-NT5E / CD73) Anti-CD59 Lucatumumab (Anti-TNFRSF5 / CD40) Anti-human CD3 (UCHT1)-InVivo Mitazalimab (Anti-TNFRSF5 / CD40) Tesnatilimab (Anti-NKG2D / CD314) Ravagalimab (Anti-TNFRSF5 / CD40)

Chemical Information, Storage & Stability

Molecular Weight	413.53	Formula	C₂₂H₂₇N₃O₃S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1700637-55-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	CD38-IN-78c, MDK-7553			Smiles	CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC

Solubility

In vitro
Batch:

DMSO : 42 mg/mL (101.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.000mg/ml (4.84mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5% DMSO 1 40%PEG300 2 55%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (12.09mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 550 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 40%PEG300 2 55%PBS Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (12.09mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 550 μL of PBS to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.150mg/ml (10.04mM)	Taking the 1 mL working solution as an example, add 50 μL 83 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	mCD38 ^[1] (Cell-free assay) 1.9 nM hCD38 ^[1] (Cell-free assay) 7.3 nM
In vitro	CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs.^[2]
In vivo	CD38 inhibitor 1 (compound 78c) is found to not only be a very potent inhibitor, but also had suitable physiochemical properties to serve as a robust tool for in vivo studies. In addition, this compound is able to elevate NAD in both liver and gastrocnemius tissue when dosed orally in a DIO mouse.^[1]
References	[1] https://pubmed.ncbi.nlm.nih.gov/25828863/ [2] https://pubmed.ncbi.nlm.nih.gov/29719225/

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