Catalog No.S1502 Synonyms: Cefalexin
Molecular Weight(MW): 347.39
Cephalexin is an antibiotic that can treat a number of bacterial infections.
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|Description||Cephalexin is an antibiotic that can treat a number of bacterial infections.|
Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0.  Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet.  Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. 
|In vivo||Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration.  Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs. |
-  Watanabe S, et al. J Pharmacol Exp Ther, 2010, 334(2), 651-656.
-  Rees CA, et al. J Am Vet Med Assoc, 2004, 224(9), 1455-1458.
-  Zarebska A, et al. Ann Univ Mariae Curie Sklodowska Med, 2004, 59(1), 145-150.
|In vitro||Water||10 mg/mL (28.78 mM)|
|DMSO||2 mg/mL (5.75 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03802552||Enrolling by invitation||Drug: Cefadroxil|Drug: Cephalexin||Osteomyelitis|Septic Arthritis|Pyomyositis||University of Colorado Denver||May 1 2019||Phase 1|
|NCT02490670||Completed||Drug: Cephalexin||Healthy||Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.||July 2015||Phase 1|
|NCT02123459||Completed||Drug: Cephalexin||Healthy Volunteers||Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.||May 2014||Phase 1|
|NCT02123472||Completed||Drug: Cephalexin||Healthy Volunteers||Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.||May 2014||Phase 1|
|NCT02123446||Completed||Drug: Cephalexin||Healthy Volunteers||Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.||April 2014||Phase 1|
|NCT02100826||Completed||Drug: Cephalexin||Healthy Volunteers||Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.||April 2014||Phase 1|
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