Cephalexin

Catalog No.S1502 Synonyms: Cefalexin

Cephalexin Chemical Structure

Molecular Weight(MW): 347.39

Cephalexin is an antibiotic that can treat a number of bacterial infections.

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Biological Activity

Description Cephalexin is an antibiotic that can treat a number of bacterial infections.
In vitro

Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0. [1] Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet. [2] Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. [3]

In vivo Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration. [4] Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs. [5]

Protocol

Solubility (25°C)

In vitro Water 10 mg/mL (28.78 mM)
DMSO 2 mg/mL (5.75 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 347.39
Formula

C16H17N3O4S

CAS No. 15686-71-2
Storage powder
in solvent
Synonyms Cefalexin

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03802552 Enrolling by invitation Drug: Cefadroxil|Drug: Cephalexin Osteomyelitis|Septic Arthritis|Pyomyositis University of Colorado Denver May 1 2019 Phase 1
NCT02490670 Completed Drug: Cephalexin Healthy Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. July 2015 Phase 1
NCT02123459 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. May 2014 Phase 1
NCT02123472 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. May 2014 Phase 1
NCT02123446 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. April 2014 Phase 1
NCT02100826 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. April 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID