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Cephalexin

Synonyms: Cefalexin

Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.

Cephalexin Chemical Structure

Cephalexin Chemical Structure

CAS: 15686-71-2

Selleck's Cephalexin has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.79%
99.79

Cephalexin Related Products

Choose Selective Bacterial Inhibitors

Biological Activity

Description Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.
In vitro
In vitro Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0. [1] Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet. [2] Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. [3]
In Vivo
In vivo Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration. [4] Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04916951 Enrolling by invitation
Neonatal Infection
University of Colorado Denver
 July 14 2021 Phase 1
NCT03802552 Completed
Osteomyelitis|Septic Arthritis|Pyomyositis
University of Colorado Denver
 May 1 2019 Phase 1
NCT02490670 Completed
Healthy
Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.
 July 2015 Phase 1
NCT02123459 Completed
Healthy Volunteers
Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.
 May 2014 Phase 1
NCT02123472 Completed
Healthy Volunteers
Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V.
 May 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 347.39 Formula

C16H17N3O4S
CAS No. 15686-71-2 SDF Download Cephalexin SDF
Smiles CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 10 mg/mL

DMSO : 5 mg/mL ( (14.39 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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