Cephalexin

Catalog No.S1502 Synonyms: Cefalexin

For research use only.

Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.

Cephalexin Chemical Structure

CAS No. 15686-71-2

Selleck's Cephalexin has been cited by 4 Publications

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.
In vitro

Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibits saturable kinetics with K(m) = 5.9 mM and a bell-shaped pH profile with a maximum at pH 7.0. [1] Cephalexin results in overestimation of glucose concentration, but only in the samples that contain the highest antimicrobial concentration (2,400microg/mL) and only for the tablet. [2] Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. [3]

In vivo Cephalexin causes a slight prolongation of 1-stage prothrombin time (PT) and activated partial thromboplastin time (PTT) and slight decrease in fibrinogen concentration in healthy dogs. Cephalexin causes a significant increase in 1-stage PT and activated PTT, amoxicillin causes a significant increase in activated PTT, and enrofloxacin causes a significant decrease in fibrinogen concentration. [4] Cephalexin results in high numbers of E. coli producing plasmid-mediated CMY-2 β-lactamase at the end of the treatment period in dogs. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 10 mg/mL
(28.78 mM)
DMSO 1 mg/mL
(2.87 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 347.39
Formula

C16H17N3O4S

CAS No. 15686-71-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04916951 Enrolling by invitation Drug: Amoxicillin|Drug: Cephalexin Neonatal Infection University of Colorado Denver July 14 2021 Phase 1
NCT03802552 Completed Drug: Cefadroxil|Drug: Cephalexin Osteomyelitis|Septic Arthritis|Pyomyositis University of Colorado Denver May 1 2019 Phase 1
NCT02490670 Completed Drug: Cephalexin Healthy Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. July 2015 Phase 1
NCT02123459 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. May 2014 Phase 1
NCT02123472 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. May 2014 Phase 1
NCT02123446 Completed Drug: Cephalexin Healthy Volunteers Eli Lilly and Company|Investigacion Farmacologica y Biofarmaceutica S.A. de C.V. April 2014 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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