Home Immunology & Inflammation PD-1/PD-L1 inhibitor CA-170 (AUPM-170) For research use only.

CA-170 (AUPM-170)

Synonyms: AUPM-170, PD-1-IN-1

CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.

CA-170 (AUPM-170) Chemical Structure

CA-170 (AUPM-170) Chemical Structure

CAS: 1673534-76-3

Purity & Quality Control

Batch: S847301 DMSO] 72 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.93%
99.93

CA-170 (AUPM-170) Related Products

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Biological Activity

Description CA-170 (AUPM-170, PD-1-IN-1 ) is potent and orally available inhibitor of the immune checkpoint regulatory proteins PD-L1 (programmed cell death ligand-1) and VISTA (V-domain immunoglobulin (Ig) suppressor of T-cell activation). CA-170 exhibits anti-tumor efficacy.
Targets
PD-L1 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02812875 Completed
Advanced Solid Tumors or Lymphomas
Curis Inc.
 May 2016 Phase 1

Chemical Information & Solubility

Molecular Weight 360.32 Formula

C12H20N6O7
CAS No. 1673534-76-3 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 72 mg/mL ( (199.82 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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