Colchicine

For research use only.

Catalog No.S2284 Synonyms: Colchineos, Colchisol, Colcin

7 publications

Colchicine Chemical Structure

Molecular Weight(MW): 399.44

Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM.

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Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM.

Protocol

References

Solubility (25°C)

In vitro DMSO 80 mg/mL (200.28 mM)
Water 80 mg/mL (200.28 mM)
Ethanol 80 mg/mL (200.28 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 399.44
Formula

C22H25NO6

CAS No. 64-86-8
Storage powder
in solvent
Synonyms Colchineos, Colchisol, Colcin
Smiles COC1=CC=C2C(=CC1=O)C(CCC3=C2C(=C(OC)C(=C3)OC)OC)NC(C)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04375202 Recruiting Drug: Colchicine 1 MG Oral Tablet COVID-19 University Of Perugia April 18 2020 Phase 2
NCT04377321 Completed Drug: Colchicine Tablets Treatment Adherence Ministry of Health and Population Egypt October 10 2019 --
NCT03927677 Not yet recruiting Drug: Xanthine Oxidase Inhibitor Gout|Hyperuricemia LG Chem October 30 2019 Phase 1
NCT03933007 Recruiting Drug: Colchicine|Drug: midazolam|Drug: fexofenadine Gout Flare Assistance Publique - Hôpitaux de Paris September 10 2019 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID