CA3(CIL56)
Catalog No.S8661
Molecular Weight(MW): 489.61
CA3 has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties.
Purity & Quality Control
Choose Selective Hippo pathway Inhibitors
Biological Activity
| Description | CA3 has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. | ||||||||||||||||
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| Targets |
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| In vitro |
CA3 strongly inhibits esophageal adenocarcinoma cell growth in vitro. CA3 can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells. CA3 specially inhibits Tead/YAP1 transcriptional activity but shows no inhibitory activity on other transcriptional factors-Super-TOP/Wnt, CBF1/Notch, and AP-1 after cotransfection of their respective individual promoter luciferases in 293T cells. CA3 preferentially inhibits CSC properties enriched in radiation-resistant esophageal adenocarcinoma cells[1]. |
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| Cell Data |
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| In vivo | CA3 exerts strong antitumor activity in xenograft model with no apparent toxicity[1]. |
Protocol
| Cell Research: |
+ Expand
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Solubility (25°C)
| In vitro | DMSO | 97 mg/mL (198.11 mM) |
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| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 489.61 |
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| Formula | C23H27N3O5S2 |
| CAS No. | 300802-28-2 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
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