Clotrimazole
Catalog No.S1606 Synonyms: BAY b 5097, FB 5097
Molecular Weight(MW): 344.84
Clotrimazole alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections.
Cited by 1 publication
Purity & Quality Control
Choose Selective Anti-infection Inhibitors
Biological Activity
| Description | Clotrimazole alters the permeability of the fungal cell wall by inhibiting the biosynthesis of ergosterol, used in the treatment of fungal infections. |
|---|---|
| In vitro |
Clotrimazole causes a sustained depletion of intracellular Ca2+ stores, which results in activation of PKR, phosphorylation of eIF2alpha, and thereby in inhibition of protein synthesis at the level of translation initiation. Clotrimazole preferentially decreases the expression of the growth promoting proteins cyclin A, E and D1, resulting in inhibition of cyclin-dependent kinase activity and blockage of cell cycle in G1.[1] Clotrimazole inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2(hTRPM2). Clotrimazole (3 mM to 30 mM) produces an essentially complete inhibition of theTRPM2-mediated current. Clotrimazole antagonizes ADP-ribose-activated whole-cell and single-channel currents in the rat insulinoma cell-line CRI-G1. [2] Clotrimazole (2 mM) causes a sharp decline in parasitemia, complete inhibition of parasite replication, and destruction of parasites and host cells within a single intraerythrocytic asexual cycle (approximately 48 hours). Clotrimazole effectively and rapidly inhibits parasite growth in five different strains of P. falciparum, in vitro, irrespective of their Chloroquine sensitivity. [3] |
| In vivo | Clotrimazole stimulates a subset of capsaicin-sensitive and mustard oil-sensitive trigeminal neurons, and evoked nocifensive behavior and thermal hypersensitivity with intraplantar injection in mice. Clotrimazole-induced pain behavior is suppressed by the TRPV1-antagonist BCTC [(N-(-4-tertiarybutylphenyl)-4-(3-cholorpyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide)] and absent in TRPV1-deficient mice. Clotrimazole inhibits the cold and menthol receptor TRPM8, and blocks menthol-induced responses in capsaicin- and mustard oil-insensitive trigeminal neurons. [4] |
Protocol
Solubility (25°C)
| In vitro | Ethanol | 69 mg/mL (200.09 mM) |
|---|---|---|
| DMSO | 11 mg/mL (31.89 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 344.84 |
|---|---|
| Formula | C22H17ClN2 |
| CAS No. | 23593-75-1 |
| Storage | powder |
| in solvent | |
| Synonyms | BAY b 5097, FB 5097 |
Bio Calculators
Molarity Calculator
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02907307 | Withdrawn | Vulvovaginal Candidiasis | Medinova AG | December 2018 | Phase 3 |
| NCT02907307 | Withdrawn | Vulvovaginal Candidiasis | Medinova AG | December 2018 | Phase 3 |
| NCT02582177 | Not yet recruiting | Tinea | Ache Laboratorios Farmaceuticos S.A. | August 1 2018 | Phase 3 |
| NCT02582177 | Not yet recruiting | Tinea | Ache Laboratorios Farmaceuticos S.A. | August 1 2018 | Phase 3 |
| NCT03599323 | Recruiting | Vaginal Candida | Bayer|SATO PHARMACEUTICAL Ltd. | July 10 2018 | -- |
| NCT03599323 | Recruiting | Vaginal Candida | Bayer|SATO PHARMACEUTICAL Ltd. | July 10 2018 | -- |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.
