C-176

Catalog No.S6575

For research use only.

STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.

C-176 Chemical Structure

CAS No. 314054-00-7

Selleck's C-176 has been cited by 9 Publications

Purity & Quality Control

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Biological Activity

Description STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
Targets
STING [1]
In vitro

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING)[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCC1806 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MVmzJIRigXN? MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR2MyQDB4IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDNiZHH5d{BjgSClZXzsMZRqfGW{LVfsc{Bz\WGpZX70JIJie2WmIHHzd4F6NCCLQ{WwJF0hPi5{IN88UU4> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNkG4NEc,OjZzMU[xPFA9N2F-
HCC38 NYTTeGpqS3m2b4TvfIlkcXS7IHHzd4F6 NWP5XnJFOyCmYYnz MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR2M{QCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA{KGSjeYOgZpkh[2WubD30bZRmei2JbH:gdoVi\2WwdDDiZZNm\CCjc4PhfUwhUUN3MDC9JFgvPyEQvF2u MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNkG4NEc,OjZzMU[xPFA9N2F-
HCC1143 NXy4U3ZuS3m2b4TvfIlkcXS7IHHzd4F6 NU\s[ZRFOyCmYYnz NF[4[|dEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS0NzMUSzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IEOg[IF6eyCkeTDj[YxtNXSrdHXyMWdtdyC{ZXHn[Y51KGKjc3XkJIF{e2G7LDDJR|UxKD1iOT61JO69VS5? NILiWmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGxOlE5OCd-Mk[xNVYyQDB:L3G+
HCC38 M2PCTmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVGzJIRigXN? NWXLOGpHS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOFM{igZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiMzDkZZl{KGK7IHPlcIwufGm2ZYKtS4xwKHKnYXflcpQh[mG|ZXSgZZN{[Xl? M2O1NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUG2NVgxLz5{NkGxOlE5ODxxYU6=
HEK293 NFHXdoZHfW6ldHnvckBie3OjeR?= MkfLNVAhfU1? MYKyOEBpenN? NILIb5VKdmO{ZXHz[UBqdiCFSF;QJI1TVkFiZYjwdoV{e2mxbjDpckBJTUt{OUOgZ4VtdHNiYYSgNVAhfU1iaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkheVKWLWDDVkBu\XSqb3S= MkPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMU[xPFAoRjJ4MUG2NVgxRC:jPh?=
HCC1806 NXLsS45GS3m2b4TvfIlkcXS7IHHzd4F6 NIrPOlg{KGSjeYO= M3m0TmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhESzF6ME[gZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIlv[3WkYYTl[EBnd3JiMzDkZZl{KGK7IHPlcIwufGm2ZYKtS4xwKHKnYXflcpQh[mG|ZXSgZZN{[Xl? NVnkWJBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVYyQDBpPkK2NVE3OThyPD;hQi=>
HCC1143 NVzKb21zS3m2b4TvfIlkcXS7IHHzd4F6 NILF[Ig{KGSjeYO= NUfVblk2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEOFMUG0N{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjCzJIRigXNiYomgZ4VtdC22aYTldk1IdG9icnXh[4VvfCCkYYPl[EBie3OjeR?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjFzNkG4NEc,OjZzMU[xPFA9N2F-
HEK293T M{jVVmZ2dmO2aX;uJIF{e2G7 MkLKNVAhfU1? NInDdGwzPCCqcoO= NXzBW4cxUW6lcnXhd4UhcW5iQ1jPVEBmgHC{ZYPzbY9vKGmwIFjFT|I6O1RiY3XscJMhe3SjYnz5JJRz[W6|ZnXjeIVlKHerdHigcJVkcW[ncnHz[UBo\W6nIHH0JFExKHWPIHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= NWXTUVhCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xNVYyQDBpPkK2NVE3OThyPD;hQi=>
In vivo

C-176 attenuates STING-associated autoinflammatory disease in mice[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: C57BL/6J mice
  • Dosages: 750 nmol/200 μL
  • Administration: ip

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 358.09
Formula

C11H7IN2O4

CAS No. 314054-00-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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