Cinepazide maleate

Catalog No.S3045

For research use only.

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

Cinepazide maleate Chemical Structure

CAS No. 26328-04-1

Purity & Quality Control

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Biological Activity

Description Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
Calcium channel [1]
In vivo Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. [1] Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. [2] Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. [3] Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia. [4]

Protocol (from reference)

Animal Research:[4]
  • Animal Models: Male Wistar rats weighing 170 g -200 g
  • Dosages: 4 mg/kg, 20 mg/kg, 100 mg/kg and 150 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 107 mg/mL
(200.53 mM)
Water 107 mg/mL
(200.53 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 533.57


CAS No. 26328-04-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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