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Cinepazide maleate

Name: Cinepazide maleate
Brand: Selleck Chemicals
SKU: S3045
Rating: 5 (1 reviews)

Catalog No.S3045 Purity: 99.82%

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

Cinepazide maleate Chemical Structure

CAS: 26328-04-1

Purity & Quality Control

Batch: S304501 DMSO] 107 mg/mL] false] Water] 107 mg/mL] false] Ethanol] Insoluble] false Purity: 99.82%

99.82

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Signaling Pathway

Calcium Channel Signaling Pathway

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

Targets

Calcium channel ^[1]

In Vivo
In vivo	Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. ^[1] Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. ^[2] Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. ^[3] Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia. ^[4]
Animal Research	Animal Models	Male Wistar rats weighing 170 g -200 g
	Dosages	4 mg/kg, 20 mg/kg, 100 mg/kg and 150 mg/kg
	Administration	i.p.

References

[4] Miwa S, et al. Jpn J Pharmacol. 1986, 41(1), 109-115.

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Chemical Information & Solubility

Molecular Weight	533.57	Formula	C₂₂H₃₁N₃O₅.C₄H₄O₄
CAS No.	26328-04-1	SDF	Download Cinepazide maleate SDF
Smiles	COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=CC(=O)O)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 107 mg/mL ( (200.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 107 mg/mL

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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