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Cinepazide maleate Calcium Channel inhibitor

Cat.No.S3045

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
Cinepazide maleate Calcium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 533.57

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Quality Control

Batch: S304501 DMSO]107 mg/mL]false]Water]107 mg/mL]false]Ethanol]Insoluble]false Purity: 99.82%
99.82

Solubility

In vitro
Batch:

DMSO : 107 mg/mL (200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 107 mg/mL

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 533.57 Formula

C22H31N3O5.C4H4O4

 Storage (From the date of receipt)
CAS No. 26328-04-1 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=CC(=O)O)C(=O)O

Mechanism of Action

Targets/IC50/Ki
Calcium channel
In vivo
Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/2426499/

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