Molecular Weight(MW): 533.57
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
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|Description||Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.|
|In vivo||Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists.  Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose.  Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%.  Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia. |
|In vitro||DMSO||107 mg/mL (200.53 mM)|
|Water||107 mg/mL (200.53 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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