Cefadroxil hydrate

Catalog No.S3636

For research use only.

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.

Cefadroxil hydrate Chemical Structure

CAS No. 66592-87-8

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.
In vitro

Cefadroxil is a first generation aminocephalosporin with good patient compliance, a long-acting therapeutic effect, high solubility and relatively broad spectrum of anti-bacterial activity. Cefadroxil is also a substrate of the intestinal peptide transporter PepT1, which is primarily responsible for the drug’s uptake across the apical membrane of small intestine[1].

In vivo Cefadroxil has low plasma protein binding (~20%) and good oral bioavailability of at least 90%. Renal excretion is the primary route of elimination, with more than 90% of the orally administered drug being excreted unchanged in urine over 24 hours[1].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: C57BL/6 mice
  • Dosages: 11, 33, 66, 132, 264 and 528 nmol/g body weight
  • Administration: oral

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 381.4
Formula

C16H17N3O5S.H2O

CAS No. 66592-87-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O.O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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