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Capsaicin(Vanilloid)

Name: Capsaicin(Vanilloid)
Brand: Selleck Chemicals
SKU: S1990
Rating: 5 (10 reviews)

Catalog No.S1990 Purity: 100%

Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.

Capsaicin(Vanilloid) Chemical Structure

CAS: 404-86-4

Selleck's Capsaicin(Vanilloid) has been cited by 10 publications

Purity & Quality Control

Batch: Purity: 100%

100

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Choose Selective TRP Channel Inhibitors

Biological Activity

Description	Capsaicin(Vanilloid) is an active component of chili peppers, which are plants belonging to the genus Capsicum.Capsaici is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.

In vitro
In vitro	Capsaicin, a TRPV-1 agonist, dose-dependently inhibits the proliferation of the HCC cell lines PLC/PRF/7, HuH7 and HepG2, which is not effected by TRPV1 channel blockers. Combining capsaicin and sorafenib significantly enhances the suppression on cell proliferation, achieving a high-level synergistic effect and promoting HCC cell apoptosis through the enhancement of p-ERK and reduction of p-STAT3 signaling.^[1]
Cell Research	Cell lines	HCC cells PLC/PRF/5, HuH7, and HepG2
	Concentrations	50, 100, 150, 200 and 250 μM
	Incubation Time	72 h
	Method	Cells (5×10³ per well) seeded in 96-well plates are exposed to capsaicin, sorafenib, or their combination for 72 h. Then, the medium is removed and the wells are washed with phosphate-buffered saline (PBS). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay is performed by adding 20 μL of MTT to the cells for 4 h. Light absorbance is measured.

In Vivo
In vivo	Combining capsaicin and sorafenib enhances inhibition of xenograft tumor growth in nude mice, with no apparent gross toxicity.^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05817591	Recruiting	Peripheral Neuropathic Pain	Centre Hospitalier Annecy Genevois	December 14 2023	--
NCT05813223	Not yet recruiting	Chronic Cough	Stuart Mazzone\|Merck Sharp & Dohme LLC\|Melbourne Health\|Monash University\|University of Melbourne	December 1 2023	Early Phase 1
NCT05840562	Not yet recruiting	Chemotherapy-induced Peripheral Neuropathy	Institut Cancerologie de l''Ouest\|Grünenthal GmbH	September 2023	Phase 3

References

[1] Zhang SS, et al. Acta Pharmacol Sin. 2018;39(3):438-448.

Chemical Information & Solubility

Molecular Weight	305.41	Formula	C₁₈H₂₇NO₃
CAS No.	404-86-4	SDF	Download Capsaicin(Vanilloid) SDF
Smiles	CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 61 mg/mL ( (199.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 61 mg/mL

Water : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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