Home Immunology & Inflammation TLR activator CU-CPD107 For research use only.

CU-CPD107

CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.

CU-CPD107 Chemical Structure

CU-CPD107 Chemical Structure

CAS: 2573912-32-8

Purity & Quality Control

Batch: S993701 DMSO] 80 mg/mL] false] Ethanol] 80 mg/mL] false] Water] Insoluble] false Purity: 98.90%
98.90

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Biological Activity

Description CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.
Targets
TLR8 [1]
(in HEK-Blue hTLR8 cells)
13.7 μM
In vitro
In vitro

CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1]
Cell Research Cell lines HEK-Blue cells, HEK-Blue hTLR cells, HEK-Blue Null1 cells
Concentrations 0-100 µM
Incubation Time 24 h
Method

Cellular toxicity was assessed using the Roche Cell Proliferation Reagent WST1 per the manufacturer's recommendation. Briefly, WST1 was diluted 1:10 into cell-containing media and assayed with absorbance at 450 nm.

Chemical Information & Solubility

Molecular Weight 400.26 Formula

C16H21IN2O2
CAS No. 2573912-32-8 SDF --
Smiles CCOCC1=NC(=C([N]1CC(C)(C)O)C2=CC=CC=C2)I
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 80 mg/mL ( (199.87 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 80 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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