Cyclothiazide

Catalog No.S6611

For research use only.

Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function.

Cyclothiazide Chemical Structure

CAS No. 2259-96-3

Selleck's Cyclothiazide has been cited by 7 Publications

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Biological Activity

Description Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function.
Targets
AMPA-type receptors [1]
()
In vitro

Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current[1].

Protocol (from reference)

Chemical Information

Molecular Weight 389.88
Formula

C14H16ClN3O4S2

CAS No. 2259-96-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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