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Carbazochrome

Synonyms: Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17

Carbazochrome (Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17) is a hemostatic agent that causes the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound.

Carbazochrome Chemical Structure

Carbazochrome Chemical Structure

CAS: 69-81-8

Purity & Quality Control

Batch: S508401 DMSO] 33 mg/mL] false] ] ] false] ] ] false Purity: 99.78%
99.78

Carbazochrome Related Products

Biological Activity

Description Carbazochrome (Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17) is a hemostatic agent that causes the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound.
In vitro
In vitro AC-17 (0.1-1 M) reversed the barrier dysfunction induced by tryptase, thrombin and bradykinin without affecting the endothelial permeability enhanced by Ca2+ ionophores such as ionomycin and A23187 or phorbol 12-myristate 13-acetate. AC-17 reversed the tryptase-induced formation of actin stress fibres and disruption of VE-cadherin in porcine aortic endothelial cells (PAECs)[2].
Cell Research Cell lines porcine aortic endothelial cells (PAECs)
Concentrations 0.1, 1, 10 μM
Incubation Time 30 min
Method

Cells were labelled with [3H]myoinositol for 12 h. After preincubation with 10 mM LiCl, cells were stimulated with 1 µM bradykinin or 10 nM thrombin. AC-17 was included 30 min before stimulation. The [3H]IP3 formed was measured at 30 s after the stimulation.
In Vivo
In vivo AC-17 is a potent agent that inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media[1].
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 10 mg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 236.23 Formula

C10H12N4O3
 
CAS No. 69-81-8 SDF --
Smiles CN1CC(C2=CC(=C(C=C21)O)N=NC(=O)N)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 33 mg/mL ( (139.69 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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