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Ciprofloxacin (CPX) hydrochloride Topoisomerase inhibitor

Name: Ciprofloxacin (CPX) hydrochloride
Brand: Selleck Chemicals
SKU: S5008
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S5008

Ciprofloxacin (CPX) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).

Chemical Structure

Molecular Weight: 367.8

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Quality Control

Batch: S500801 Water]30 mg/mL]false]DMSO]7 mg/mL]false]Ethanol]Insoluble]false Purity: 98%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV
Other Topoisomerase Inhibitors	Camptothecin (CPT) Betulinic acid (S)-10-Hydroxycamptothecin Beta-Lapachone Ellagic acid Amonafide Voreloxin (SNS-595) hydrochloride Hydroxy Camptothecine Cu(II)-Elesclomol Genz-644282

Solubility

In vitro
Batch:

Water : 30 mg/mL

DMSO : 7 mg/mL (19.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.350mg/ml (0.95mM)	Taking the 1 mL working solution as an example, add 50 μL of 7 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.350mg/ml (0.95mM)	Taking the 1 mL working solution as an example, add 50 μL of 7 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	367.8	Formula	C₁₇H₁₉ClFN₃O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	93107-08-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Bay-09867			SMILES	Cl.OC(=O)C1=CN(C2CC2)C3=CC(=C(F)C=C3C1=O)N4CCNCC4

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	DNA gyrase
References	[1] https://pubmed.ncbi.nlm.nih.gov/3292209/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-18)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06728072	RECRUITING	Colorectal Cancer; CRC	Virginia Commonwealth University	2025-03-07	PHASE2
NCT06810583	RECRUITING	Leukemia; Acute Myeloid Leukemia; Lymphoblastic Leukemia in Children	St. Jude Children's Research Hospital	2025-05-22	PHASE1
NCT07028424	NOT_YET_RECRUITING	PDAC - Pancreatic Ductal Adenocarcinoma	GERCOR - Multidisciplinary Oncology Cooperative Group	2025-07	PHASE2
NCT07704359	NOT_YET_RECRUITING	Perianal Abscess; Anal Fistula	University of Illinois at Chicago	2026-08-03	PHASE4
NCT07625267	WITHDRAWN	Acute Uncomplicated Diverticulitis	Montefiore Medical Center	2026-07-01	PHASE4
NCT07788404	RECRUITING	Prosthetic Joint Infection; Osteomyelitis; Staphylococcal Infections	Groupe Hospitalier Diaconesses Croix Saint-Simon	2023-06-10

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