Calcipotriene

For research use only.

Catalog No.S3739 Synonyms: Calcipotriol, MC903

1 publication

Calcipotriene Chemical Structure

Molecular Weight(MW): 412.60

Calcipotriene is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

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Selleck's Calcipotriene has been cited by 1 publication

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Biological Activity

Description Calcipotriene is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
In vitro

Calcipotriene enhances IL-10 secretion in psoriatic skin and in human T cells, induces secretion of type 2 cytokines by T cells and, significantly modulates the differentiation of DCs and T cells[1].

In vivo Calcipotriol suppresses skin cancer development in mice in a TSLP-dependent manner. Calcipotriol is a well-tolerated topical medication for psoriasis. The low concentration of calcipotriol in the clinically available formulation (0.005% ointment) dampens its effect against skin cancer development in mice[2].

Protocol

Cell Research:[1]
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  • Cell lines: Monocytes (CD14+ cells)-derived DCs
  • Concentrations: 100 nM
  • Incubation Time: 24 h or 3 days
  • Method: Cells are treated in duplicates with 100 nM calcipotriol, 1 mM betamethasone (BDP), combination of calcipotriol and betamethasone (100 nM/1 mM; ratio 1:10 as in the fixed-combination product) or a corresponding vehicle control (0.1% DMSO). Treatment is applied after the first 5 days in culture and before and throughout the 3 days of activation with LPS and IFN-γ or two days after activation with LPS and IFN-γ and throughout the last 24 h of activation.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: genetically engineered mouse models
  • Dosages: 80 nM
  • Administration: topical
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 82 mg/mL (198.73 mM)
Water Insoluble
Ethanol '82 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 412.60
Formula

C27H40O3

CAS No. 112965-21-6
Storage powder
in solvent
Synonyms Calcipotriol, MC903
Smiles CC(\C=C\C(O)C1CC1)C2CCC3/C(CCCC23C)=C/C=C\4CC(O)CC(O)C4=C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03596073 Recruiting Drug: Topical Calcipotriene Ointment|Other: Topical Vaseline Breast Cancer Massachusetts General Hospital November 7 2018 Phase 1
NCT03476746 Completed Drug: LEO 90100 foam|Drug: Dovobet® ointment Healthy LEO Pharma March 20 2018 Phase 1
NCT03462927 Completed Drug: MC2-01 Cream|Drug: CAL/BDP combination Psoriasis Vulgaris MC2 Therapeutics February 8 2018 Phase 2
NCT02605057 Completed Drug: LEO 80185 gel|Drug: Dovobet(r) Ointment Psoriasis Vulgaris LEO Pharma November 2015 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID