Chlorpromazine HCl

Catalog No.S2456 Synonyms: Sonazine

For research use only.

Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.

Chlorpromazine HCl Chemical Structure

CAS No. 69-09-0

Selleck's Chlorpromazine HCl has been cited by 18 publications

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Biological Activity

Description Chlorpromazine HCl (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
Dopamine receptor [6] Potassium channel [6]
In vitro

Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the binding (kon) and by increasing the unbinding (koff) rates of GABAARs. [1] Chlorpromazine modulates activated TRPA1 currents in a voltage-dependent way, leading to a block at positive potentials and an increased open probability at negative potentials. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells MUXGeY5kfGmxbjDhd5NigQ>? MXLDc41xd3WwZDD3ZZMh\X[jbIXheIVlKG[xcjD0bIUh[mmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JHs{UF16LV;IMWRRSVRvbHHi[Yxm\CB3LXj5[JJwgHm2conweIFucW6nIEHBJJJm[2WydH;yJJNqfGW|IHnuJINtd26nZDDDTG8h[2WubIOsJGtqRTBwNkezJO69VQ>? M33JOVgxQTd3M{i=
CHO cells M4PhO2Z2dmO2aX;uJIF{e2G7 MVHDc41xd3WwZDD3ZZMh\X[jbIXheIVlKG[xcjD0bIUh[mmwZHnu[{Bi\m[rbnn0fUBi\2GrboP0JHs{UF2XLUi2MFE4OC2uYXLlcIVlKER{IIPpeIV{KGmwIHPsc45m\CCFSF:gZ4VtdHNuIFvpQVAvODB|IN88US=> NYrsPWp6QDB7N{WzPC=>
In vivo Chlorpromazine independently down-regulates the production of various T cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and up-regulates the secretion of IL-10 in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine -mediated amplification of the SEB-driven Chlorpromazine secretion is accompanied by an enhanced IL-10 mRNA accumulation. [3] Chlorpromazine protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and inhibits TNF serum levels. Chlorpromazine protects against LPS lethality when administered 30 minutes (min) before, simultaneously, or up to 10 min after LPS and is ineffective when given 30 min after LPS, paralleling the inhibitory effect on TNF production. Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity in mice sensitized to LPS toxicity by actinomycin D, whereas under these conditions DEX is inactive. [4] Chlorpromazine protects brain tissue from hypoxia-induced irreversible loss of synaptic transmission in rats. Chlorpromazine also significantly delays the occurrence of the hypoxia-induced spreading depression (SD) in rats. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 71 mg/mL
(199.81 mM)
Water 71 mg/mL
(199.81 mM)
Ethanol 71 mg/mL
(199.81 mM)

Chemical Information

Molecular Weight 355.33


CAS No. 69-09-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03548714 Completed Drug: PT150|Other: Beverage Alcohol Dependence|Alcohol Interaction Pop Test Oncology LLC|Pharmacotherapies for Alcohol and Substance Abuse Consortium|Congressionally Directed Medical Research Programs|Michael E. DeBakey VA Medical Center|Baylor College of Medicine|University of California San Diego September 1 2018 Phase 1
NCT02943213 Completed Drug: Chlorpromazine Hydrochloride Anti-Psychotic|Management of Manifestations of Psychotic Disorders|Treatment of Schizophrenia|Control Nausea and Vomiting|Relief of Restlessness and Apprehension Before Surgery|Acute Intermittent Porphyria|Adjunct in the Treatment of Tetanus|Control Manifestations of the Manic Type of Mani-depressive Illness|Relief of Intractable Hiccups Cycle Pharmaceuticals Ltd.|Parexel November 2016 Phase 1
NCT02295462 Completed Other: Person-centered Care|Other: Optimised Treatment Dementia Martin-Luther-Universität Halle-Wittenberg|University of Luebeck|University of Witten/Herdecke December 2014 Not Applicable

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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