Cetylpyridinium Chloride

Catalog No.S4172

Cetylpyridinium Chloride Chemical Structure

Molecular Weight(MW): 339.99

Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

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Biological Activity

Description Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
In vitro

Cetylpyridinium chloride (CPC) as active ingredient of antiseptic oral mouthrinses has a broad antimicrobial spectrum with a rapid bactericidal effect on gram-positive pathogens and a fungicide effect on yeasts in particular. Application of CPC at a concentration of 0.05% as a mouthrinse results in an immediate reduction in bacterial counts of 2.0 to 2.5 log steps (which is adequate to > 99%). This reverts to about 1 log step (= 90%) 1 h after application. The ability of CPC to inhibit plaque and thereby reduce gingivitis is assured. In comparison to chlorhexidine, CPC has a lower residual effect, and as a result a lesser effect against plaque and gingivitis. The efficacy of CPC against oropharyngeal candidiasis is assured. CPC mouthrinses can significantly reduce infectious aerosols in dental practice, thereby protecting both staff and the patient. The balance of intra-oral bacterial flora is not disturbed even in the case of relatively long-term use of CPC (up to six weeks). [1]

In vivo Cetylpyridinium chloride increases the risk of severe allergic reactions, such as swelling of the mouth, face, lips or tongue, labored breathing, rashes, and hives. Ingesting high concentrations of cetylpyridinium chloride can lead to lung damage. Cetylpyridinium chloride is toxic if swallowed or inhaled. [2]

Protocol

Solubility (25°C)

In vitro DMSO 68 mg/mL (200.0 mM)
Water 68 mg/mL (200.0 mM)
Ethanol 68 mg/mL (200.0 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 339.99
Formula

C21H38N.Cl

CAS No. 123-03-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03706781 Completed Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. November 14 2017 Phase 1
NCT03706781 Completed Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. November 14 2017 Phase 1
NCT03179735 Enrolling by invitation Gingivitis University of Taubate June 1 2017 Phase 4
NCT03179735 Enrolling by invitation Gingivitis University of Taubate June 1 2017 Phase 4
NCT02788786 Completed Periodontitis|Premature Birth of Newborn Johns Hopkins Bloomberg School of Public Health|Bill and Melinda Gates Foundation June 27 2016 Phase 2
NCT02788786 Completed Periodontitis|Premature Birth of Newborn Johns Hopkins Bloomberg School of Public Health|Bill and Melinda Gates Foundation June 27 2016 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID