Cetylpyridinium Chloride

Catalog No.S4172

For research use only.

Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.

Cetylpyridinium Chloride Chemical Structure

CAS No. 123-03-5

Purity & Quality Control

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Biological Activity

Description Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
In vitro

Cetylpyridinium chloride (CPC) as active ingredient of antiseptic oral mouthrinses has a broad antimicrobial spectrum with a rapid bactericidal effect on gram-positive pathogens and a fungicide effect on yeasts in particular. Application of CPC at a concentration of 0.05% as a mouthrinse results in an immediate reduction in bacterial counts of 2.0 to 2.5 log steps (which is adequate to > 99%). This reverts to about 1 log step (= 90%) 1 h after application. The ability of CPC to inhibit plaque and thereby reduce gingivitis is assured. In comparison to chlorhexidine, CPC has a lower residual effect, and as a result a lesser effect against plaque and gingivitis. The efficacy of CPC against oropharyngeal candidiasis is assured. CPC mouthrinses can significantly reduce infectious aerosols in dental practice, thereby protecting both staff and the patient. The balance of intra-oral bacterial flora is not disturbed even in the case of relatively long-term use of CPC (up to six weeks). [1]

In vivo Cetylpyridinium chloride increases the risk of severe allergic reactions, such as swelling of the mouth, face, lips or tongue, labored breathing, rashes, and hives. Ingesting high concentrations of cetylpyridinium chloride can lead to lung damage. Cetylpyridinium chloride is toxic if swallowed or inhaled. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 68 mg/mL
(200.0 mM)
Water 68 mg/mL
(200.0 mM)
Ethanol 68 mg/mL
(200.0 mM)

Chemical Information

Molecular Weight 339.99
Formula

C21H38N.Cl

CAS No. 123-03-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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