For research use only.
CAS No. 123-03-5
Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
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|Description||Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.|
Cetylpyridinium chloride (CPC) as active ingredient of antiseptic oral mouthrinses has a broad antimicrobial spectrum with a rapid bactericidal effect on gram-positive pathogens and a fungicide effect on yeasts in particular. Application of CPC at a concentration of 0.05% as a mouthrinse results in an immediate reduction in bacterial counts of 2.0 to 2.5 log steps (which is adequate to > 99%). This reverts to about 1 log step (= 90%) 1 h after application. The ability of CPC to inhibit plaque and thereby reduce gingivitis is assured. In comparison to chlorhexidine, CPC has a lower residual effect, and as a result a lesser effect against plaque and gingivitis. The efficacy of CPC against oropharyngeal candidiasis is assured. CPC mouthrinses can significantly reduce infectious aerosols in dental practice, thereby protecting both staff and the patient. The balance of intra-oral bacterial flora is not disturbed even in the case of relatively long-term use of CPC (up to six weeks). 
|In vivo||Cetylpyridinium chloride increases the risk of severe allergic reactions, such as swelling of the mouth, face, lips or tongue, labored breathing, rashes, and hives. Ingesting high concentrations of cetylpyridinium chloride can lead to lung damage. Cetylpyridinium chloride is toxic if swallowed or inhaled. |
|In vitro||DMSO||68 mg/mL (200.0 mM)|
|Water||68 mg/mL (200.0 mM)|
|Ethanol||68 mg/mL (200.0 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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