Catalog No.S8997

For research use only.

680C91 is a potent and selective inhibitor of TDO with Ki of 51 nM.

680C91 Chemical Structure

CAS No. 163239-22-3

Purity & Quality Control

Choose Selective IDO/TDO Inhibitors

Biological Activity

Description 680C91 is a potent and selective inhibitor of TDO with Ki of 51 nM.
TDO [1]
(Cell-free assay)
51 nM(Ki)
In vitro

68OC91 is a potent (Ki = 51 nM) and selective TDO inhibitor with no inhibitory activity against indoleamine 2,3-dioxygenase (EC, monoamine oxidase A and B, 5-HT uptake and 5-HT1A,1D,2A and 2c receptors at a concentration of 10 μM. 68OC91 has no effect on the binding of tryptophan to serum albumin in plasma and inhibited TDO competitively with respect to its substrate tryptophan. 68OC91 inhibits the catabolism of tryptophan by rat liver cells and rat liver perfused in situ.[1]

In vivo

The catabolism of L-[ring-2-14C]-tryptophan and a load dose of tryptophan (100 mg/kg) in vivo are inhibited by prior administration of 68OC91. Administration of 68OC91 alone produces marked increases in brain tryptophan, 5-HT and 5-HIAA. A load dose of tryptophan (100 mg/kg), producing increases in brain tryptophan 4-fold greater than that seen with 68OC91, does not increase brain 5-HT and 5-HIAA to levels greater than those seen with 68OC91 and produces a shorter-lasting increase in these parameters.[1]

Protocol (from reference)

Cell Research:


  • Cell lines: rat liver cells
  • Concentrations: 0.1 μM, 0.5 μM, 2 μM
  • Incubation Time: 0 min - 120 min
  • Method:

    The combined concentration of the L-[ring-2-14C]-tryptophan and non-labelled L-tryptophan used in the assays is 20 μM and is added either with or without 68OC91 at time zero.

Animal Research:


  • Animal Models: Male Wistar rats
  • Dosages: 15 mg/kg
  • Administration: Oral gavage

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 238.26


CAS No. 163239-22-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CN=C1)C=CC2=CNC3=C2C=CC(=C3)F

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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