For research use only. Not for use in humans.

Cova322 (Anti-IL-17 & TNF-Alpha)

Cat.No.A4043

Cova322 is a bispecific FynomAb targeting TNF and IL-17A, created by fusing a small anti-IL-17A Fynomer to the anti-TNF antibody adalimumab. It shows potent inhibition of TNF and IL-17A in vitro and in vivo, offering potential benefits for inflammatory disease treatment. M.W 161.9 kDa.

Quality Control

Specificity

Name	Citation	TNF-α	TNF-alpha	Others
QNZ (EVP4593)	155	++++		NF-κB
JTE-607 Dihydrochloride	0	++++	++++	IL-1beta,IL-8,IL-6
PF-3644022	1	+		MK2
UCB-9260	0	+++	+++	NF-κB
MD2-TLR4-IN-1	0	+		TLR4,IL-6
R-7050	8	+		IL-1β
Resatorvid (TAK-242)	62	++++		TLR4,IL-6,NO
Apigenin-7-O-glucuronide	0	✔
UTL-5g	0	✔
Benpyrine racemate	1	✔
Amarogentin	0	✔		TAS2R1,AMPK
Stylopine	0	✔		IL-1β,NO,COX-2
Myrislignan	1	✔		iNOS,IL-6,NF-κB
NE 52-QQ57	1	✔		iNOS,IL-6,IL-1β
(3R,8S)-Falcarindiol	3	✔		IL-1β,IL-6,iNOS
Gardenoside	0	✔		NF-κB,P2X7 Receptor,IL-6
Cucurbitacin IIb	0	✔		JNK,STAT3,NF-κB
IQ 3	1	✔		IL-6,JNK3,JNK1
Isuzinaxib (APX-115 free base)	0	✔		IL-6,MCP-1/CCL2,NOX2
AUDA	0	✔		Smad3,TGF-β,IL-1β
CPI-1189	1	✔
Madecassic acid	1	✔		IL-1β,COX-2,iNOS
Homoplantaginin	1	✔		IL-6,IKKβ,NF-κB
2',5'-Dihydroxyacetophenone	1	✔		IL-6,NF-κB,ERK1/2
Forsythoside B	0	✔		IκB,NF-κB,IL-6
Mulberroside A	0	✔		ERK,NF-κB,Caspase-1
Ginsenoside Rb1	4	✔		TLR3,NF-κB,IRAK-1
Muscone	4	✔		IL-6,IL-1β,NLRP3 inflammasome
(±)-Shikonin	38	✔		NF-κB,Proteasome,chemokine receptor
Methylthiouracil	0	✔		IL-6,ERK1/2,NF-κB

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Cova322 is a bispecific FynomAb targeting TNF and IL-17A, created by fusing a small anti-IL-17A Fynomer to the anti-TNF antibody adalimumab. It shows potent inhibition of TNF and IL-17A in vitro and in vivo, offering potential benefits for inflammatory disease treatment. M.W 161.9 kDa.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	N/A
Source	CHO
Storage (From the date of receipt)	-80℃(avoid freeze-thaw cycles)

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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Handling Instructions

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