Home Biosimilar Antibodies Apoptosis TNF-alpha inhibitor -Interleukins antibody Cova322 (Anti-IL-17 & TNF-Alpha) For research use only.
Not for use in humans.

Cova322 (Anti-IL-17 & TNF-Alpha)

Cova322 is a bispecific FynomAb targeting TNF and IL-17A, created by fusing a small anti-IL-17A Fynomer to the anti-TNF antibody adalimumab. It shows potent inhibition of TNF and IL-17A in vitro and in vivo, offering potential benefits for inflammatory disease treatment. M.W 161.9 kDa.

Cova322 (Anti-IL-17 & TNF-Alpha)

Purity & Quality Control

Choose Selective TNF-alpha Inhibitors

Name Citation TNF-α TNF-alpha Others
QNZ (EVP4593) 148 NF-κB
JTE-607 Dihydrochloride 0 IL-1beta,IL-8,IL-6
PF-3644022 1 MK2
UCB-9260 0 NF-κB
MD2-TLR4-IN-1 0 TLR4,IL-6
R-7050 8 IL-1β
Resatorvid (TAK-242) 59 TLR4,IL-6,NO
Apigenin-7-O-glucuronide 0
UTL-5g 0
Benpyrine racemate 1
Amarogentin 0 TAS2R1,AMPK
Stylopine 0 IL-1β,NO,COX-2
Myrislignan 1 iNOS,IL-6,NF-κB
NE 52-QQ57 1 iNOS,IL-6,IL-1β
(3R,8S)-Falcarindiol 3 IL-1β,IL-6,iNOS
Gardenoside 0 NF-κB,P2X7 Receptor,IL-6
Cucurbitacin IIb 0 JNK,STAT3,NF-κB
IQ 3 1 IL-6,JNK3,JNK1
Isuzinaxib (APX-115 free base) 0 IL-6,MCP-1/CCL2,NOX2
AUDA 0 Smad3,TGF-β,IL-1β
CPI-1189 1
Madecassic acid 1 IL-1β,COX-2,iNOS
Homoplantaginin 1 IL-6,IKKβ,NF-κB
2',5'-Dihydroxyacetophenone 1 IL-6,NF-κB,ERK1/2
Forsythoside B 0 IκB,NF-κB,IL-6
Mulberroside A 0 ERK,NF-κB,Caspase-1
Ginsenoside Rb1 4 TLR3,NF-κB,IRAK-1
Muscone 3 IL-6,IL-1β,NLRP3 inflammasome
(±)-Shikonin 37 NF-κB,Proteasome,chemokine receptor
Methylthiouracil 0 IL-6,ERK1/2,NF-κB
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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description Cova322 is a bispecific FynomAb targeting TNF and IL-17A, created by fusing a small anti-IL-17A Fynomer to the anti-TNF antibody adalimumab. It shows potent inhibition of TNF and IL-17A in vitro and in vivo, offering potential benefits for inflammatory disease treatment. M.W 161.9 kDa.

Product Details

CAS No. N/A
Source CHO
Storage
(From the date of receipt)		 -80℃(avoid freeze-thaw cycles)

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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