Capecitabine (RO 09-1978)
For research use only.
CAS No. 154361-50-9
Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.
Selleck's Capecitabine (RO 09-1978) has been cited by 16 publications
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A452 induces apoptosis and DNA damage of CRC cells. (A) HCT116 and (B) HT29 cells were cultured with 0.1% DMSO (control) or A452 (0.5, 1, 2 uM), SAHA (5 uM), cisplatin (10 uM), irinotecan (5 uM), or capecitabine (10 uM) at the indicated concentrations for 24 h. The Western blot analysis shows PARP degradation, proapoptotic and antiapoptotic markers. α-Tubulin is shown as a loading control.
Carcinogenesis, 2018, 39(1):72-83. Capecitabine (RO 09-1978) purchased from Selleck.
A, HCT116 and (B) HT29 cells were treated with 0.1% DMSO (control), A452 (2 µM), SAHA (5 µM), cisplatin (10 µM), irinotecan (5 µM), or capecitabine (10 µM) alone or in combination with these compounds at the indicated concentrations for 24 h. The total protein was analyzed by western blotting with α‐tubulin as a loading control.
Mol Carcinog, 2018, 57(10):1383-1395. Capecitabine (RO 09-1978) purchased from Selleck.
Live Dead Assay fluorescent microscopic images of C6 colon cancer cells exposed to (A) free drug Cap for 24 h, (B) PLGA Cap NPs for 24 h, (C) free drug Cap for 150 h, and (D) PLGA Cap NPs for 150 h.
J Drug Deliv Sci Tec, 2018, doi:10.1016/j.jddst.2018.05.025. Capecitabine (RO 09-1978) purchased from Selleck.
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|Description||Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.|
|Features||A tumor-selective fluoropyrimidine carbamate.|
Both LS174T WT and LS174T-c2 cells show significantly greater sensitivity to Capecitabine when cultivated in the same plates as HepG2 hepatoma with IC50 values of 890 and 630 μM in LS174T WT alone and cultivated with HepG2, respectively. In addition, for the LS174T-C2 subline, the IC50 falls from 330 ± 4 down to 89 ± 6 μm when cultivated in the same plates as hepatoma cells. Furthermore, Capecitabine induces apoptosis in a Fas-dependent manner, and shows a 7-fold higher cytotoxicity and markedly stronger apoptotic potential in thymidine phosphorylase (TP)-transfected LS174T-c2 cells. 
|In vivo||In the human cancer xenograft models studied, Capecitabine is more effective in a wider dose range and has a broader spectrum of antitumor activity than 5-FU, UFT or its intermediate metabolite 5'-DFUR, which can be correlated with tumor dThdPase levels.  Capecitabine inhibits tumor growth and metastatic recurrence after resection of human hepatocellular carcinoma (HCC) in highly metastatic nude mice model which is attributed to the high expression of platelet-derived endothelial cell growth factor in tumors. |
|In vitro||DMSO||72 mg/mL (200.36 mM)|
|Water||6 mg/mL (16.69 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04861987||Not yet recruiting||Drug: PCS6422 and capecitabine||Advanced Cancer|Refractory Cancer|Tumor Gastric||Processa Pharmaceuticals||June 17 2021||Phase 1|
|NCT03132025||Unknown status||Drug: Apatinib and Capecitabine|Drug: Capecitabine||Metastatic Colorectal Cancer||Yanqiao Zhang|Harbin Medical University||April 30 2017||Phase 2|
|NCT02754011||Recruiting||Drug: Combination of ribociclib + capecitabine||Breast Cancer||UNICANCER|Novartis||January 2017||Phase 1|
|NCT02915172||Withdrawn||Drug: Lenvatinib|Drug: Capecitabine||Advanced Cancer|Malignant Neoplasm of Breast|Malignant Neoplasms of Bone and Articular Cartilage|Malignant Neoplasms of Digestive Organs|Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System|Malignant Neoplasms of Female Genital Organs|Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites|Malignant Neoplasms of Independent (Primary) Multiple Sites|Malignant Neoplasms of Lip Oral Cavity and Pharynx|Malignant Neoplasms of Male Genital Organs|Malignant Neoplasms of Mesothelial and Soft Tissue|Malignant Neoplasms of Respiratory and Intrathoracic Organs|Malignant Neoplasms of Thyroid and Other Endocrine Glands|Malignant Neoplasms of Urinary Tract||M.D. Anderson Cancer Center|Eisai Inc.||December 2016||Phase 1|
|NCT03465202||Unknown status||Drug: Capecitabine||Breast Cancer|Colorectal Cancer||Newcastle-upon-Tyne Hospitals NHS Trust|University of Newcastle Upon-Tyne||May 2016||Phase 4|
|NCT01050985||Completed||Drug: Temsirolimus and capecitabine||Advanced Solid Tumors||Georgetown University|Wyeth is now a wholly owned subsidiary of Pfizer||July 2010||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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