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Catalog No.S1156 Synonyms: RO 09-1978

16 publications

Capecitabine  Chemical Structure

CAS No. 154361-50-9

Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.

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10mM (1mL in DMSO) USD 137 In stock
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Selleck's Capecitabine has been cited by 16 publications

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  • Growth curve of human colon cancer xenografts in nude mice treated with orally administered vehicle or capecitabine at 360 mg/kg (n = 10–12 per cell line).

    Cancer Res, 2017, 77(24):7120-7130. Capecitabine purchased from Selleck.

  • Cells were seeded in 96 well paltes, and then treated with the indicated concentration of Capecitabine for 48 h. Cell survival was measured by a standarad MTT assay.



    Dr. Helen Sadik of Johns Hopkins University. Capecitabine purchased from Selleck.

  • A452 induces apoptosis and DNA damage of CRC cells. (A) HCT116 and (B) HT29 cells were cultured with 0.1% DMSO (control) or A452 (0.5, 1, 2 uM), SAHA (5 uM), cisplatin (10 uM), irinotecan (5 uM), or capecitabine (10 uM) at the indicated concentrations for 24 h. The Western blot analysis shows PARP degradation, proapoptotic and antiapoptotic markers. α-Tubulin is shown as a loading control.

    Carcinogenesis, 2018, 39(1):72-83. Capecitabine purchased from Selleck.

  • A, HCT116 and (B) HT29 cells were treated with 0.1% DMSO (control), A452 (2 µM), SAHA (5 µM), cisplatin (10 µM), irinotecan (5 µM), or capecitabine (10 µM) alone or in combination with these compounds at the indicated concentrations for 24 h. The total protein was analyzed by western blotting with α‐tubulin as a loading control.

    Mol Carcinog, 2018, 57(10):1383-1395. Capecitabine purchased from Selleck.

  • Live Dead Assay fluorescent microscopic images of C6 colon cancer cells exposed to (A) free drug Cap for 24 h, (B) PLGA Cap NPs for 24 h, (C) free drug Cap for 150 h, and (D) PLGA Cap NPs for 150 h.

    J Drug Deliv Sci Tec, 2018, doi:10.1016/j.jddst.2018.05.025. Capecitabine purchased from Selleck.

  • (A) Antitumor-growth ability of AZD6244. (B) The single AZD6244 exhibited better efficacy than Capecitabine, while the combination of both shown a significant synergistic effect.

    Mol Med Rep, 2017, 16(4):4784-4790. Capecitabine purchased from Selleck.

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Description Capecitabine (RO 09-1978) is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis.
Features A tumor-selective fluoropyrimidine carbamate.
Thymidine phosphorylase [1]
In vitro

Both LS174T WT and LS174T-c2 cells show significantly greater sensitivity to Capecitabine when cultivated in the same plates as HepG2 hepatoma with IC50 values of 890 and 630 μM in LS174T WT alone and cultivated with HepG2, respectively. In addition, for the LS174T-C2 subline, the IC50 falls from 330 ± 4 down to 89 ± 6 μm when cultivated in the same plates as hepatoma cells. Furthermore, Capecitabine induces apoptosis in a Fas-dependent manner, and shows a 7-fold higher cytotoxicity and markedly stronger apoptotic potential in thymidine phosphorylase (TP)-transfected LS174T-c2 cells. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human RKOp27 cells M4LqVmN6fG:2b4jpZ:Kh[XO|YYm= MYqzJIRigXN? MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDST29xOjdiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME20MlM{KM7:TR?= NF24V4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1OlY2PSd-MkCzOVY3PTV:L3G+
RKOp27 NEfrNVJEgXSxdH;4bYNqfHliYYPzZZk> MkW3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVmtQeDJ5IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFA1OzNizszNMi=> NHnYT2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO0OVU5OSd-MUmzOFU2QDF:L3G+

... Click to View More Cell Line Experimental Data

In vivo In the human cancer xenograft models studied, Capecitabine is more effective in a wider dose range and has a broader spectrum of antitumor activity than 5-FU, UFT or its intermediate metabolite 5'-DFUR, which can be correlated with tumor dThdPase levels. [2] Capecitabine inhibits tumor growth and metastatic recurrence after resection of human hepatocellular carcinoma (HCC) in highly metastatic nude mice model which is attributed to the high expression of platelet-derived endothelial cell growth factor in tumors. [3]


Cell Research:[1]
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  • Cell lines: HepG2, LS174T WT and LS174T-c2 cells
  • Concentrations: ~1 mM
  • Incubation Time: 72 hours
  • Method: HepG2 and either LS174T WT or LS174T-c2 cells are seeded, respectively, in the top and bottom chambers of 8-well strip membranes in 96-well plates. The exponentially growing cells are exposed to increasing concentrations of capecitabine. The medium is supplemented with 750 ng/mL ZB4 MoAB or 100 ng/mL BR17 MoAB when the latter are used in the experiments. After 72 hours of continuous exposure, LS174T viability is assessed using the classic colorimetric MTT test.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: BALB/c nu/nu mice are inoculated s.c. with small pieces of CXF280 xenograft tissues
  • Dosages: ≤1.5 mM/kg/day
  • Administration: Administered via p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 72 mg/mL (200.36 mM)
Ethanol 72 mg/mL (200.36 mM)
Water 6 mg/mL (16.69 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 359.35


CAS No. 154361-50-9
Storage powder
in solvent
Synonyms RO 09-1978
Smiles CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04198727 Recruiting Other: DPD activity assessment|Drug: Capecitabine Breast Neoplasm Malignant Female Centre Antoine Lacassagne|Cerbaliance July 20 2020 Not Applicable
NCT04274933 Terminated Drug: Venetoclax|Drug: Capecitabine Breast Cancer|Cancer AbbVie May 21 2020 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID