Catalog No.S1156 Synonyms: RO 09-1978
Molecular Weight(MW): 359.35
Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.
Cited by 8 Publications
6 Customer Reviews
Growth curve of human colon cancer xenografts in nude mice treated with orally administered vehicle or capecitabine at 360 mg/kg (n = 10–12 per cell line).
Cancer Res, 2017, 77(24):7120-7130. Capecitabine purchased from Selleck.
A452 induces apoptosis and DNA damage of CRC cells. (A) HCT116 and (B) HT29 cells were cultured with 0.1% DMSO (control) or A452 (0.5, 1, 2 uM), SAHA (5 uM), cisplatin (10 uM), irinotecan (5 uM), or capecitabine (10 uM) at the indicated concentrations for 24 h. The Western blot analysis shows PARP degradation, proapoptotic and antiapoptotic markers. α-Tubulin is shown as a loading control.
Carcinogenesis, 2018, 39(1):72-83. Capecitabine purchased from Selleck.
A, HCT116 and (B) HT29 cells were treated with 0.1% DMSO (control), A452 (2 µM), SAHA (5 µM), cisplatin (10 µM), irinotecan (5 µM), or capecitabine (10 µM) alone or in combination with these compounds at the indicated concentrations for 24 h. The total protein was analyzed by western blotting with α‐tubulin as a loading control.
Mol Carcinog, 2018, 57(10):1383-1395. Capecitabine purchased from Selleck.
Live Dead Assay fluorescent microscopic images of C6 colon cancer cells exposed to (A) free drug Cap for 24 h, (B) PLGA Cap NPs for 24 h, (C) free drug Cap for 150 h, and (D) PLGA Cap NPs for 150 h.
J Drug Deliv Sci Tec, 2018, doi:10.1016/j.jddst.2018.05.025. Capecitabine purchased from Selleck.
Purity & Quality Control
Choose Selective DNA/RNA Synthesis Inhibitors
|Description||Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.|
|Features||A tumor-selective fluoropyrimidine carbamate.|
Both LS174T WT and LS174T-c2 cells show significantly greater sensitivity to Capecitabine when cultivated in the same plates as HepG2 hepatoma with IC50 values of 890 and 630 μM in LS174T WT alone and cultivated with HepG2, respectively. In addition, for the LS174T-C2 subline, the IC50 falls from 330 ± 4 down to 89 ± 6 μm when cultivated in the same plates as hepatoma cells. Furthermore, Capecitabine induces apoptosis in a Fas-dependent manner, and shows a 7-fold higher cytotoxicity and markedly stronger apoptotic potential in thymidine phosphorylase (TP)-transfected LS174T-c2 cells. 
|In vivo||In the human cancer xenograft models studied, Capecitabine is more effective in a wider dose range and has a broader spectrum of antitumor activity than 5-FU, UFT or its intermediate metabolite 5'-DFUR, which can be correlated with tumor dThdPase levels.  Capecitabine inhibits tumor growth and metastatic recurrence after resection of human hepatocellular carcinoma (HCC) in highly metastatic nude mice model which is attributed to the high expression of platelet-derived endothelial cell growth factor in tumors. |
|In vitro||DMSO||72 mg/mL (200.36 mM)|
|Ethanol||72 mg/mL (200.36 mM)|
|Water||6 mg/mL (16.69 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04031872||Not yet recruiting||Drug: LY3200882||Colorectal Cancer Metastatic||The Netherlands Cancer Institute|Vall d''Hebron Institute of Oncology|Agendia|European Organisation for Research and Treatment of Cancer - EORTC|Azienda Ospedaliera Niguarda Cà Granda|Fundación para la Investigación del Hospital Clínico de Valencia|University of Campania Luigi Vanvitelli|University of Turin Italy|Eli Lilly and Company|Catalan Institute of Health|Universitaire Ziekenhuizen Leuven||February 2020||Phase 1|Phase 2|
|NCT04088955||Recruiting||Other: DigiMeds||Colon Cancer|Breast Cancer|Rectal Cancer||Proteus Digital Health Inc.||September 2019||--|
|NCT03958721||Recruiting||Drug: Capecitabine|Radiation: Radiotherapy||Resistant Breast Cancer|Non-metastatic Invasive Breast Cancer||A Bapsi Chakravarthy MD|Vanderbilt-Ingram Cancer Center||July 18 2019||Phase 1|
|NCT03930771||Recruiting||Drug: Capecitabine|Drug: Temozolomide||Recurrent Pituitary Adenomas||Weill Medical College of Cornell University||May 21 2019||Phase 2|
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