Home Transmembrane Transporters Sodium Channel inhibitor - COVID-19 inhibitor Camostat Mesilate

Camostat Mesilate

Catalog No.S2874 Synonyms: FOY-305, FOY-S980

For research use only.

Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

Camostat Mesilate Chemical Structure

CAS No. 59721-29-8

Selleck's Camostat Mesilate has been cited by 11 Publications

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Biological Activity

Description Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
Targets
epithelial sodium channel (ENaC) [1]
50 nM
In vitro

Camostat (30 μM) prolongs attenuation of ENaC function in human airway epithelial cell models that is reversible upon the addition of excess trypsin. [1] Camostat mesilate (500 mM) inhibits generation of TGF-beta by suppressing plasmin activity and reduces the activity of TGF-beta, which blocks in vitro activation of HSCs. [2] Camostat mesilate (20 mM) combined with insulin results a significant hypoglycemic effect following large intestinal administration. Camostat mesilate (20 mM) is effective in reducing insulin degradation in both small and large intestinal homogenates of rats. [3] Camostat mesilate (2 mM) inhibits MCP-1 and TNF- production in activated rat monocytes. Camostat mesilate (2 mM) inhibits proliferation and MCP-1 production of cultured rat PSCs. [4]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Caco-2 NXvhU5djTnWwY4Tpc44h[XO|YYm= M{TLeFQ5KGixdYLz MXPE[ZRmem2rbnH0bY9vKG:oIFnDOVAhfmGudXXzJIZweiCrbnjpZol1cW:wIH;mJHNCWlNvQ3;WMVIhcW6mdXPl[EBkgXSxdH;4bYNqfHlib3[gR4Fkdy1{IHPlcIx{KGGodHXyJFQ5KGixdYLzJIJ6KGirZ3igZ49vfGWwdDDpcYFocW6pLDDJR|UxKD1iMD62OEDPxE1w M{DoUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg2OTZ2Lze+R4hGVUKOPD;hQi=>
Click to View More Cell Line Experimental Data
In vivo Camostat (100 μg/kg i.t.) induces a potent and prolonged attenuation of ENaC activity in the guinea pig trachea. [1] Camostat mesilate (1-2 mg/g of diet) markedly attenuats an increase in hepatic plasmin and TGF-beta levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum–treated rats. [2] Camostat mesilate (1 mg/g) prevents pancreatic atrophy and improves pancreatic exocrine function of rat chronic pancreatitis induced by DBTC. Camostat mesilate (1 mg/g) inhibits chronic inflammation and pancreatic fibrosis induced by DBTC. Camostat mesilate (1 mg/g) inhibits the development of pancreatic fibrosis and PSCs activation in the pancreas induced by DBTC. Camostat mesilate (1 mg/g) suppresses monocytes infiltration and inhibits MCP-1 expression both in serum and in pancreatic tissue. [4] Camostat mesilate (100 mg/kg) significantly increases the body weight and pancreatic wet weight, and it significantly inhibits inflammatory changes and fibrosis of the pancreas through the suppression of gene expressions of PAP, p8, and cytokines in rat chronic pancreatitis. [5]

Protocol (from reference)

Animal Research:[2]
  • Animal Models: male Wistar rats
  • Dosages: 2 mg/g
  • Administration: Diet

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 494.52
Formula

C20H22N4O5.CH4O3S
CAS No. 59721-29-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04455815 Terminated Drug: Camostat COVID-19 Infection Cancer Research UK|Latus Therapeutics September 25 2020 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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