Home Endocrinology & Hormones Estrogen/progestogen Receptor modulator Cyclofenil

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Cyclofenil Estrogen/progestogen Receptor modulator

Cat.No.S5393

Cyclofenil is a selective estrogen receptor modulator showing a higher affinity for ERβ than Erα.
Cyclofenil Estrogen/progestogen Receptor modulator Chemical Structure

Chemical Structure

Molecular Weight: 364.43

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Quality Control

Batch: S539301 DMSO]21 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 364.43 Formula

C23H24O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2624-43-3 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(=O)OC1=CC=C(C=C1)C(=C2CCCCC2)C3=CC=C(C=C3)OC(=O)C

Solubility

In vitro
Batch:

DMSO : 21 mg/mL (57.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
ERβ [1]
ERα [1]
In vitro
The relative binding affinity of Cyclofenil for Erβ and Erα is 124 and 285, respectively[1].
References

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