Cholesterol

Catalog No.S4154

Cholesterol Chemical Structure

Molecular Weight(MW): 386.65

Cholesterol is the principal sterol of all higher animals required to build and maintain membranes.

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Biological Activity

Description Cholesterol is the principal sterol of all higher animals required to build and maintain membranes.
In vitro

Cholesterol serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. It modulates membrane fluidity over the range of physiological temperatures. The hydroxyl group on cholesterol interacts with the polar head groups of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which reduces membrane fluidity. The structure of the tetracyclic ring of cholesterol contributes to the decreased fluidity of the cell membrane as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar. In this structural role, cholesterol reduces the permeability of the plasma membrane to neutral solutes, protons, and sodium ions.

In vivo Cholesterol is recycled. The liver excretes it in a non-esterified form (via bile) into the digestive tract. Typically about 50% of the excreted cholesterol is reabsorbed by the small bowel back into the bloodstream.

Protocol

References

Solubility (25°C)

In vitro DMSO 0.03 mg/mL (0.07 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 386.65
Formula

C27H46O

CAS No. 57-88-5
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03296098 Suspended Drug: Ulipristal acetate Contraception|Healthy Female Health Decisions|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) December 2020 Phase 2
NCT04102891 Not yet recruiting Other: Microbiota modulation diet Metabolic Syndrome|Gut Bacteria|Personalized Nutrition SmartWithFood|Vlaams Instituut voor Biotechnologie|KU Leuven February 2020 Not Applicable
NCT03989167 Not yet recruiting Other: Clinical decision support Hypercholesterolemia Familial|Clinical Decision Support University Hospital Linkoeping January 2020 Not Applicable
NCT03602456 Not yet recruiting Other: Kentucky HEALTH Health Insurance University of Pennsylvania|Columbia University|NORC at the University of Chicago January 1 2020 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID