Catalog No.S5842 Synonyms: FCE-21336
Molecular Weight(MW): 451.60
Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.
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|Description||Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor.|
Cabergoline prevents the oxidative stress-induced cell death of cultured cortical neurons via a D2 receptor-mediated mechanism. Cabergoline suppresses the activation of ERK signaling, which might have a role in the neuroprotection. Cabergoline significantly represses extracellular glutamate accumulation triggered by oxidative stress, and increases the expression of glutamate transporters including EAAC1, which is known to be involved in the clearance of extracellular glutamate.
|In vivo||Cabergoline has a long elimination half-life (63 to 109 h). An in vivo study of neuronal damage induced by intracerebroventricular (icv) injection of 6-OHDA, a neurotoxic compound that selectively damages dopaminergic neurons in male ICR mice, demonstrates that intraperitoneal (ip) administration of cabergoline for 7 days prevented nigrostriatal region dopaminergic neurons from cell death. Cabergoline also protects SH-SY5Y neuroblastoma from cell death by oxygen-glucose deprivation even when cabergoline is administered after the induction of cell death. Cabergoline increases hippocampal brain-derived neurotrophic factor (BDNF, an important regulator in the synaptic plasticity) and exerts an antidepressant effect in rats.|
|In vitro||DMSO||90 mg/mL (199.29 mM)|
|Ethanol||90 mg/mL (199.29 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03965572||Recruiting||--||Lactation Suppressed|Cabergoline Adverse Reaction|Postpartum DVT|Postpartum Depression||Laniado Hospital||June 7 2019||--|
|NCT03457389||Not yet recruiting||Drug: Cabergoline||Pituitary Adenoma|Prolactinoma|Pituitary Tumor|Recurrence Tumor||Seoul National University Hospital||October 1 2018||Not Applicable|
|NCT01915303||Active not recruiting||Drug: Pasireotide with or without cabergoline||Cushing''s Disease||Novartis Pharmaceuticals|Novartis||March 6 2014||Phase 2|
|NCT01651364||Completed||Drug: Placebo|Drug: Cabergoline||Cocaine Dependence|Cocaine Abuse|Cocaine Addiction|Substance Abuse||Baylor College of Medicine|National Institute on Drug Abuse (NIDA)||July 2011||Phase 1|
|NCT01270711||Completed||Drug: Study Drug||Parkinson''s Disease|Hyperprolactinemia||Pfizer||November 2010||--|
|NCT01009567||Completed||Drug: Cabergoline|Drug: Control||Ovarian Hyperstimulation Syndrome||Royan Institute||June 2009||Phase 1|Phase 2|
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