Choline Fenofibrate

Catalog No.S5812

Choline Fenofibrate Chemical Structure

Molecular Weight(MW): 421.91

Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.

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Biological Activity

Description Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.
In vitro

WAY-316606 enhances hair shaft production, hair shaft keratin expression, and inhibits spontaneous HF regression (catagen) ex vivo. WAY-316606 effectively enhances β-catenin activity in mammalian skin cell populations, namely in both human hair pre-cortex keratinocytes and DP fibroblasts ex vivo[1].

Protocol

Solubility (25°C)

In vitro Water 9 mg/mL (21.33 mM)
Ethanol 7 mg/mL (16.59 mM)
DMSO 5 mg/mL (11.85 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 421.91
Formula

C22H28ClNO5

CAS No. 856676-23-8
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00683176 Completed Diabetic Macular Edema Abbott Products|Abbott September 2008 Phase 2
NCT00683176 Completed Diabetic Macular Edema Abbott Products|Abbott September 2008 Phase 2
NCT00673881 Completed Dyslipidemia Radiant Research March 2008 Phase 1|Phase 2
NCT00673881 Completed Dyslipidemia Radiant Research March 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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PPAR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID