research use only

Carbenoxolone Sodium

Name: Carbenoxolone Sodium
Brand: Selleck Chemicals
SKU: S4368
Availability: InStock
Rating: 5 (5 reviews)

Cat.No.S4368

Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.

Chemical Structure

Molecular Weight: 614.72

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S436801 DMSO]23 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.98%

99.98

Related Targets	Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell PROTAC Antibiotics for Mammalian Cell Culture ADC Linker Antibiotics for Plant Cell Culture PROTAC Linker Hydrotropic Agents Antibody-Drug Conjugate E3 ligase Ligand Target Protein Ligand Molecular Glues Enzyme Substrate Drug-Linker Conjugates for ADC Chelating Agent
Related Products	BAPTA-AM Rat IgG2b isotype control-InVivo Blebbistatin Methyl-β-cyclodextrin (MβCD) AP-III-a4 (ENOblock) Carbazochrome sodium sulfonate (AC-17) Ursolic Acid Osthole 4-Methylumbelliferone (4-MU) Dioscin Ethidium bromide Pitstop 2 Sesamin Bilobalide Formononetin Hesperidin Azeliragon (TTP488) L-Mimosine Vitexin N6022 Dp44mT Chlorogenic Acid Sphingosine Chrysin Coenzyme Q10 (CoQ10) Spermine Tetrahydrochloride 2-NBDG D-Lin-MC3-DMA (MC3) Morin Hydrate Ethylenediaminetetraacetic acid

Chemical Information, Storage & Stability

Molecular Weight	614.72	Formula	C₃₄H₄₈Na₂O₇	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	7421-40-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+]

Solubility

In vitro
Batch:

DMSO : 23 mg/mL ( (37.41 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Carbenoxolone induces astrocytes a reversible suppression of spontaneous action potential discharges, synaptic currents and synchronised calcium oscillations. Carbenoxolone inhibits oscillatory activity induced by the GABAA antagonist, bicuculline.Carbenoxolone causes an increase in the action potential threshold and strongly decreases the firing rate in response to a sustained depolarising current in astrocytes. ^[1] Carbenoxolone (100 μM) reduces photoreceptor-to-horizontal cell synaptic transmission by 92% in the Retina. Carbenoxolone (100 μM) reduces cone Ca channel current by 37%, reduces depolarization-evoked [Ca²⁺] signals in fluo-4 loaded retinal slices by 57% and inhibits Ca channels in Müller cells by 52% in the Retina. ^[2] Carbenoxolone abolishes the generation of full or partial ectopic spike generation, as well as spontaneous epileptiform activity in CA3 or CA1 regions of the rat hippocampal slices via closing GJ channels. ^[3]
In vivo	Carbenoxolone (400 mg/kg) decreases the duration of seizure producing protection against seizure but failing to protect against mortality.Carbenoxolone significantly increases sleeping time and decreased latency in doses of 100 mg/kg, 200 mg/kg and 300 mg/kg in mice dose dependently. Carbenoxolone (400 mg/kg) shows muscle relaxant activity and in the accelerated rotarod test, Carbenoxolone in doses of 200 mg/kg and 300 mg/kg shows a decline in motor coordination. ^[3] Carbenoxolone (12.5 mg/day) leads to a significant reduction in average birth weight (20% fall) in rats. ^[4] Carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. ^[5]
References	https://pubmed.ncbi.nlm.nih.gov/14514879/ https://pubmed.ncbi.nlm.nih.gov/15028741/ https://pubmed.ncbi.nlm.nih.gov/12720572/ https://pubmed.ncbi.nlm.nih.gov/8932995/ https://pubmed.ncbi.nlm.nih.gov/9486087/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):