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Carbenoxolone Sodium

Name: Carbenoxolone Sodium
Brand: Selleck Chemicals
SKU: S4368
Rating: 5 (5 reviews)

Catalog No.S4368 Purity: 99.98%

Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.

Carbenoxolone Sodium Chemical Structure

CAS: 7421-40-1

Selleck's Carbenoxolone Sodium has been cited by 5 publications

Purity & Quality Control

Batch: S436801 DMSO] 23 mg/mL] false] Ethanol] 6 mg/mL] false] Water] Insoluble] false Purity: 99.98%

99.98

Carbenoxolone Sodium Related Products

Biological Activity

Description	Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels.

In vitro
In vitro	Carbenoxolone induces astrocytes a reversible suppression of spontaneous action potential discharges, synaptic currents and synchronised calcium oscillations. Carbenoxolone inhibits oscillatory activity induced by the GABAA antagonist, bicuculline.Carbenoxolone causes an increase in the action potential threshold and strongly decreases the firing rate in response to a sustained depolarising current in astrocytes. ^[1] Carbenoxolone (100 μM) reduces photoreceptor-to-horizontal cell synaptic transmission by 92% in the Retina. Carbenoxolone (100 μM) reduces cone Ca channel current by 37%, reduces depolarization-evoked [Ca²⁺] signals in fluo-4 loaded retinal slices by 57% and inhibits Ca channels in Müller cells by 52% in the Retina. ^[2] Carbenoxolone abolishes the generation of full or partial ectopic spike generation, by 4-aminopyridine, as well as spontaneous epileptiform activity in CA3 or CA1 regions of the rat hippocampal slices via closing GJ channels. ^[3]

In Vivo
In vivo	Carbenoxolone (400 mg/kg) decreases the duration of seizure producing protection against seizure but failing to protect against mortality in comparison with diazepam.Carbenoxolone significantly increases sleeping time and decreased latency in doses of 100 mg/kg, 200 mg/kg and 300 mg/kg in mice dose dependently. Carbenoxolone (400 mg/kg) shows muscle relaxant activity and in the accelerated rotarod test, Carbenoxolone in doses of 200 mg/kg and 300 mg/kg shows a decline in motor coordination. ^[3] Carbenoxolone (12.5 mg/day) leads to a significant reduction in average birth weight (20% fall) in rats. ^[4] Carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. ^[5]

References

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Chemical Information & Solubility

Molecular Weight	614.72	Formula	C₃₄H₄₈Na₂O₇
CAS No.	7421-40-1	SDF	Download Carbenoxolone Sodium SDF
Smiles	CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 23 mg/mL ( (37.41 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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