For research use only.
Licensed and Manufactured by Pfizer Catalog No.S2830
CAS No. 18323-44-9
Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
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|Description||Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.|
Clindamycin is a semisynthetic analogue of lincomycin. Clindamycin primarily inhibits the initiation of peptide chain synthesis by deregulating enzyme-catalyzed initiation of peptide bounds. Clindamycin appears to have a modest effect on protein synthesis by certain mammalian cells.  Clindamycin is active against most gram-positive aerobic bacteria. Clindamycin is about eight times more active than lincomycin against Staphylococcus aureus and Streptococcus pneumonia. Clindamycin is four times more active than erythromycin against S. aureus and is active even against strains that are resistant to erythromycin, penicillin, and methicillin. Clindamycin is active against gram-positive anaerobes. Clindamycin highly activates against Bacteroides specie.  Clindamyci also alters the bacterial surface in such a way that phagocytosis and intracellular killing of the bacteria is greatly facilitated. Clindamycin potentiates opsonization and phagocytosis. 
|In vivo||Clindamycin (50mg/kg daily administrated by intramuscular) increases the survival rate of monkeys infected with penicillin-resistant S. aureu to 87.5% (7/8).  Clindamycin (40 mg/kg administrated three times daily) protects 87.5% (7/8) of rabbits from anaerobic pulmonary infections induced by transtracheal inoculation of a mixture of B. fragillis, Streptococcus morbillorm, Fusobacterium nucleatum and Eubacterium lentum.  Clindamycin (400 mg/kg treated by mixed in the diet) increases survival rate of mice infected with the Toxoplasma gondii to 100%, while all animals die in untreated group. |
-  Keusch GT, et al. J Infect Dis, 1976, 133(5), 578-587.
-  Dhawan VK, et al. Rev Infect Dis, 1982, 4(6), 1133-1153.
-  Carlisle HN, et al. Appl Microbiol, 1971, 21(3), 440-446.
|In vitro||DMSO||85 mg/mL (200.0 mM)|
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In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04946500||Active not recruiting||--||Prosthetic Joint Infection|Staphylococcus||University Hospital Brest||May 15 2021||--|
|NCT04220918||Recruiting||--||Medication Adherence|Medication Reaction||Children''s Hospital of Philadelphia|National Institute on Deafness and Other Communication Disorders (NIDCD)|Monell Chemical Senses Center||February 14 2020||--|
|NCT03845790||Recruiting||Other: Blood and microdialysis samples||Surgical Site Infection||Poitiers University Hospital||May 26 2019||Phase 1|
|NCT02782078||Completed||Biological: Clindamycin and rifampicin dosages||Staphylococcal Infections||Assistance Publique - Hôpitaux de Paris||March 6 2017||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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