Clindamycin HCl

Licensed by Pfizer Catalog No.S2457

Clindamycin HCl  Chemical Structure

Molecular Weight(MW): 461.44

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
50S ribosomal [1]
In vitro

Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. [1]

In vivo Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. [1] Clindamycin hydrochloride significantly reduces oral malodor from the dogs' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. [2] Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. [3] Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days. [4]


Solubility (25°C)

In vitro DMSO 92 mg/mL (199.37 mM)
Water 92 mg/mL (199.37 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.44


CAS No. 21462-39-5
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01929278 Completed Acne Vulgaris Stiefel a GSK Company|GlaxoSmithKline December 8 2008 Phase 1
NCT02782078 Recruiting Staphylococcal Infections Assistance Publique - Hôpitaux de Paris March 6 2017 Not Applicable
NCT01132443 Completed Acne Vulgaris Stiefel a GSK Company|GlaxoSmithKline May 6 2010 Phase 1
NCT02309346 Recruiting Septic Abortion Hospital de Clinicas de Porto Alegre December 31 2014 Phase 4
NCT03522441 Recruiting Acne Vulgaris Akorn Inc.|Catawba April 27 2018 Phase 3
NCT01715610 Withdrawn Peritonsillar Abscess Lawson Health Research Institute May 24 2012 Not Applicable

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