Home Microbiology Anti-infection chemical Colistin

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Colistin Anti-infection chemical

Cat.No.E0525

Colistin(Polymyxin E), a cyclic polypeptide antibiotic synthesized by Bacillus polymyxa subspecies colistinus Koyama, exerts antimicrobial activity by targeting at the bacterial cell membrane.
Colistin Anti-infection chemical Chemical Structure

Chemical Structure

Molecular Weight: 1155.43

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Quality Control

Batch: E052501 Water]100 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99%
99

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 1155.43 Formula

C52H98N16O13

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1066-17-7 -- Storage of Stock Solutions

Synonyms Polymyxin E SMILES NA

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-06-04)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07004049 RECRUITING
Bloodstream Infection; Ventilator Associated Bacterial Pneumonia; Hospital Acquired Bacterial Pneumonia; Carbapenem Resistant Bacterial Infection; Multidrug Resistance
National University of Singapore
 2025-04-21 PHASE4
NCT07326540 RECRUITING
Hospital Acquired Bacterial Pneumonia (HABP); Ventilator Associated Bacterial Pneumonia (VABP); Colistin Resistanrt ABC; Acinetobacter Baumannii-calcoaceticus Complex
BioVersys SAS
 2026-03-27 PHASE3
NCT07668141 NOT_YET_RECRUITING
Nephrotoxicity
Helwan University
 2026-06-30 PHASE3
NCT06819462 RECRUITING
Ventilator-Associated Pneumonia (VAP); Inha'le'd
Southeast University, China
 2025-04-01
NCT07089186 RECRUITING
Hospital-acquired Bacterial Pneumonia (HABP); Ventilator-associated Bacterial Pneumonia (VABP); Complicated Intra-abdominal Infection (cIAI); Complicated Urinary Tract Infection (cUTI); Bloodstream Infection (BSI)
Qilu Pharmaceutical Co., Ltd.
 2025-04-12 PHASE3
NCT06834971 RECRUITING
Ventilator-Associated Pneumonia (VAP)
Qilu Hospital of Shandong University
 2025-07-15

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