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Catalog No.S7891

6 publications

CC-115 Chemical Structure

CAS No. 1228013-15-7

CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.

Selleck's CC-115 has been cited by 6 publications

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Biological Activity

Description CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.
DNA-PK [2]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
PI3Kα [2]
(Cell-free assay)
0.013 μM 0.021 μM 0.852 μM
In vitro

CC-115 inhibits the DNA damage repair pathway and TORK in CLL cells and induces caspase-dependent cell death in resting CLL cells. It induces cell death with an IC50 of 0.51 µM. CC-115 reverts CD40-induced chemoresistance. CC-115 treatment significantly reduces induction of expression Mcl-1, Bfl-1, and Bcl-XL on CD40 stimulation in CLL cells. It also blocks proliferation of CLL cells. In healthy B cells, CC-115 induces cell death with an IC50 of 0.93 µM. CC-115 and NU7441 completely block the proliferation of CD4+ and CD8+ T cells. Taken together, CC-115 induces direct cytotoxicity and can block signaling pathways that are important for CLL survival, chemo-resistance and proliferation in the in the LN microenvironment[1].

Methods Test Index PMID
Growth inhibition assay

PubMed: 29088817     

Cellular growth inhibition for CC-115 across a panel of 123 cell lines of hematological (red), breast (blue), hepatocellular (teal), head and neck (dark blue) and non small cell lung cancer (green) tumor types.

Western blot
p-DNA-PK / DNA-PK / p-ATM / ATM / p-NBS1 / p-AKT / AKT / p-4EBP1 / 4EBP1 ; 

PubMed: 29088817     

Inhibition of mTOR, DNA-PK and ATM biomarkers in MDA-MB-436 cell lines. The experiments were independently performed at least 3 times and representative data are presented.

In vivo CC-115 decreases lymphadenopathy in CLL patients[1]. CC-115 shows good in vivo PK profiles across multiple species with 53%, 76%, and ∼100% oral bioavailability in mouse, rat, and dog, respectively. CC-115 has favorable physicochemical and pharmacokinetic properties, demonstrates in vivo mTOR pathway inhibition and tumor growth inhibition, as well as a good in vitro and in vivo safety profile, suitable for clinical development[2].


Cell Research:


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  • Cell lines: CLL cells
  • Concentrations: 0.35, 1, 3.5 μM
  • Incubation Time: 30 min
  • Method:

    Freshly isolated CLL cells are treated with different concentrations of CC-115 for 30 minutes. Subsequently, the cells are exposed to 5-Gy γ-radiation or treated with 10 µg/mL bleomycin (EMD Millipore, Billerica, MA) and incubated for 30 minutes, and cell lysates are made.

    (Only for Reference)

Solubility (25°C)

In vitro DMSO 67 mg/mL (199.19 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 336.35


CAS No. 1228013-15-7
Storage powder
in solvent
Synonyms N/A
Smiles CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01353625 Completed Drug: CC-115 Glioblastoma Multiforme|Squamous Cell Carcinoma of Head and Neck|Prostate Cancer|Ewing''s Osteosarcoma|Chronic Lymphocytic Leukemia|Neoplasm Metastasis Celgene April 25 2011 Phase 1

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DNA-PK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID