Home Transmembrane Transporters TRP Channel inhibitor CBA (TRPM4-IN-5)

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CBA (TRPM4-IN-5) TRP Channel inhibitor

Cat.No.S6070

CBA (TRPM4-IN-5, Compound 5) is a highly selective blocker of the TRPM4 ion channel with an IC50 of 1.5μM.
CBA (TRPM4-IN-5) TRP Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 340.16

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S607001 DMSO]68 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.92%
99.92

Chemical Information, Storage & Stability

Molecular Weight 340.16 Formula

C15H11Cl2NO4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 351424-20-9 -- Storage of Stock Solutions

Synonyms Compound 5, TRPM4 inhibitor 5 Smiles OC(=O)C1=C(NC(=O)COC2=CC=CC=C2Cl)C=C(Cl)C=C1

Solubility

In vitro
Batch:

DMSO : 68 mg/mL ( (199.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
TRPM4 [1]
1.5µM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06026280 Recruiting
Job Stress|Distress Emotional
Inspiration at Work|Northwestern University
 August 7 2023 Not Applicable
NCT05364138 Recruiting
Breast Cancer|Benign Breast Disease|Cervix Cancer
Brigham and Women''s Hospital|Partners in Health|Rwanda Biomedical Centre|Johns Hopkins University
 July 31 2023 --
NCT05862038 Recruiting
Atrial Fibrillation
Ana Jordan|University Hospital Dubrava
 February 10 2023 --
NCT05414890 Recruiting
NMO Spectrum Disorder|NMDA-R Encephalitis|Diagnostic Self Evaluation|Immune System Diseases|Nervous System Diseases|Autoimmune Diseases of the Nervous System|Autoimmune Diseases
Beijing Tiantan Hospital|Tianjin Medical University General Hospital
 June 30 2022 --

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