CCF642

Synonyms: AC1LYELL

CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.

CCF642 Chemical Structure

CCF642 Chemical Structure

CAS: 346640-08-2

Selleck's CCF642 has been cited by 2 publications

Purity & Quality Control

Batch: S828101 DMSO] 15 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 98.18%
98.18

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Biological Activity

Description CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.
Targets
protein disulfide isomerases [1]
In vitro
In vitro In vitro, CCF642 inhibits PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. Computational modeling suggests a novel covalent binding mode in active-site CGHCK motifs. CCF642 causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release[1].
In Vivo
In vivo CCF642 displays potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolongs the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib[1].
Animal Research Animal Models C57BL/KaLwRij mice
Dosages 10 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 378.45 Formula

C15H10N2O4S3

CAS No. 346640-08-2 SDF Download CCF642 SDF
Smiles COC1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(S3)[N+](=O)[O-])SC2=S
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 15 mg/mL ( (39.63 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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