For research use only.
Catalog No.S4727 Synonyms: Stugeron|Dimitronal|Stutgin|Cinarizine
CAS No. 298-57-7
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
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|Description||Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.|
Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists.
|In vivo||Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism. Its half-life is 4 hours.|
|In vitro||DMSO||73 mg/mL (198.09 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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