Cinnarizine

For research use only.

Catalog No.S4727 Synonyms: Stugeron|Dimitronal|Stutgin|Cinarizine

Cinnarizine Chemical Structure

CAS No. 298-57-7

Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.

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Biological Activity

Description Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.
Targets
Calcium channel [1] Histamine receptor [3]
In vitro

Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists[3].

In vivo Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures[2]. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism[3]. Its half-life is 4 hours.

Protocol

Cell Research:[4]
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  • Cell lines: mouse B16 melanoma cells(4A5)
  • Concentrations: 0.625, 1.25, 2.5, 5, 10, 20 μM
  • Incubation Time: 48 h
  • Method: MTT assay is performed to examine the viability of cells. Afterwards, the cells are incubated with the samples for 48 h, the culture medium is removed and replaced with 1 mg/mL MTT solution dissolved in phosphate-buffered saline (PBS) and incubated for an additional 2 h. The MTT solution is then removed and DMSO was added, following which the absorbance of the dissolved formazan crystals is determined at 570 nm by a spectrophotometer.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: Male albino mice
  • Dosages: 30 mg/kg
  • Administration: i.p
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 73 mg/mL (198.09 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 368.51
Formula

C26H28N2

CAS No. 298-57-7
Storage powder
in solvent
Synonyms Stugeron|Dimitronal|Stutgin|Cinarizine
Smiles C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID