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Carperitide Acetate

Cat.No.P1087

Caperitide acetate is a synthetic analog of human atrial natriuretic peptide (ANP) containing 28 amino acids. It acts as an inhibitor of endothelin-1 secretion when stimulated by angiotensin II (Ang II), likely through a cGMP-dependent mechanism.It induces natriuresis, diuresis, and vasodilation, effectively reducing blood volume and easing cardiac strain. By suppressing the renin-angiotensin-aldosterone system (RAAS), it aids in preventing myocardial remodeling and fibrosis, thereby enhancing cardiac function and decreasing the incidence of postoperative atrial fibrillation, heart failure, and stroke. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

Amino-acid Sequence

Carperitide Acetate Amino-acid Sequence

CAS No. 1366000-58-9

Quality Control

Batch: Purity: 99%
99

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

Water : 60 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


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Biological Activity

Description Caperitide acetate is a synthetic analog of human atrial natriuretic peptide (ANP) containing 28 amino acids. It acts as an inhibitor of endothelin-1 secretion when stimulated by angiotensin II (Ang II), likely through a cGMP-dependent mechanism.It induces natriuresis, diuresis, and vasodilation, effectively reducing blood volume and easing cardiac strain. By suppressing the renin-angiotensin-aldosterone system (RAAS), it aids in preventing myocardial remodeling and fibrosis, thereby enhancing cardiac function and decreasing the incidence of postoperative atrial fibrillation, heart failure, and stroke. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.
Targets/IC50/Ki
NPR-A

References
  • https://pubmed.ncbi.nlm.nih.gov/1310444/
  • https://pubmed.ncbi.nlm.nih.gov/25840580/

Product Information

Molecular Formula

C129H207N45O41S3
Molecular Weight 3140.49
CAS No. 1366000-58-9
Appearance White Powder
Peptide Content (by %N) ≥80%
Single Impurity (by HPLC) ≤1.0%
Assay (By Anhydrous, Acetic Acid-free) 95.0~105.0%
MS Consistent
Packing plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt)		 3 years-20°C powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)