Carmofur

Catalog No.S1289 Synonyms: HCFU

Carmofur Chemical Structure

Molecular Weight(MW): 257.26

Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.

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Biological Activity

Description Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.
Targets
Acid ceramidase [1]
In vitro

Carmofur is one of the masked compounds of 5-FU, which was modified for more potent antineoplastic activity and less toxicity. Carmofur is converted in vivo into 5-FU directly or via intermetabolites, such as 1-(carboxypentylcarbamoyl)-5-fluorouracil and/or 1-(carboxypropylcarbomoyl)-5-fluorouraci. Carmofur and its metabolites gradually accumulate in the brain during continuous administration and are removed very slowly. Carmofur has potent neurotoxicity which can produce severe leucoencephalopathy resembling methotrexate leucoencephalopathy both clinically and on brain CT, together with a cerebellar syndrome similar to that following 5-FU neurotoxicity. [1]

In vivo Carmofur or 5-FU together with Nicardipine, a Ca2+ antagonist, causes a higher level of the FU in tumor tissue and potentiation of an antitumor effect on human gastric cancer transplanted into nude mice. [2] Carmofur exerts almost the same growth-inhibitory effects on both tumors in therapeutic experiments using nude mice bearing parent or subcutaneously transplanted 5-FU-resistant DLD-1 cells. [3]

Protocol

Solubility (25°C)

In vitro DMSO 52 mg/mL (202.13 mM)
Ethanol 10 mg/mL (38.87 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 257.26
Formula

C11H16FN3O3

CAS No. 61422-45-5
Storage powder
in solvent
Synonyms HCFU

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID