For research use only.
Catalog No.S8512 Synonyms: CVC, TBR-652
CAS No. 497223-25-3
Cenicriviroc (CVC, TAK-652, TBR-652) is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.
Selleck's Cenicriviroc (TAK-652) has been cited by 1 publication
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|Description||Cenicriviroc (CVC, TAK-652, TBR-652) is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. Cenicriviroc also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.|
Migration of mouse monocytes in response to CCL2, the most potent mediator of chemotaxis for activated macrophages, is reduced following pre-treatment with Cenicriviroc at a concentration of 1 μM.
Cenicriviroc significantly reduces monocyte/macrophage recruitment in vivo at doses >= 20 mg/kg/day (p < 0.05). At these doses, Cenicriviroc shows antifibrotic effects, with significant reductions in collagen deposition (p < 0.05), and collagen type 1 protein and mRNA expression across the three animal models of fibrosis. In the NASH model, Cenicriviroc significantly reduces the nonalcoholic fatty liver disease activity score (p < 0.05 vs. controls). Cenicriviroc treatment has no notable effect on body or liver/kidney weight.
|In vitro||DMSO||100 mg/mL (143.48 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT05033314||Not yet recruiting||Drug: Rivaroxaban 10 MG|Drug: Placebo||Sickle Cell Disease|Central Venous Catheter Thrombosis|Venous Thromboembolism||Kevin H.M. Kuo MD MSc FRCPC|University Health Network Toronto||September 1 2021||Phase 3|
|NCT05029063||Not yet recruiting||Drug: Rivaroxaban 10 MG||Venous Thromboembolism|Cancer||Ottawa Hospital Research Institute||September 2021||Phase 3|
|NCT04674371||Recruiting||Other: central venous catheter insertion||Data Collection||Wolfram Schummer MD PhD|Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin||May 2021||--|
|NCT04906512||Recruiting||Device: Tegaderm CHG Dressing||Central Venous Catheter Exit Site Infection|Catheter-Related Infections||3M||May 2021||Not Applicable|
|NCT04767113||Not yet recruiting||Drug: Heparin sodium|Drug: Normal saline||Cardiac Surgery|Central Venous Catheter Thrombosis|Heparin||Guangdong Provincial People''s Hospital||March 1 2021||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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