Cyclobenzaprine HCl

Catalog No.S4283

For research use only.

Cyclobenzaprine HCl is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms; A 5-HT2 receptor antagonist.

Cyclobenzaprine HCl Chemical Structure

CAS No. 6202-23-9

Purity & Quality Control

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Biological Activity

Description Cyclobenzaprine HCl is a muscle relaxant by blocking pain sensations, used for the treatment of muscle spasms; A 5-HT2 receptor antagonist.
Targets
5-HT2 receptor [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 62 mg/mL
(198.81 mM)
Water 62 mg/mL
(198.81 mM)
Ethanol 62 mg/mL
(198.81 mM)

Chemical Information

Molecular Weight 311.85
Formula

C20H22ClN

CAS No. 6202-23-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03443960 Completed Drug: TNX-102 SL 5.6 mg|Drug: Amrix 30 mg Healthy Subjects Tonix Pharmaceuticals Inc. January 29 2018 Phase 1
NCT03168022 Completed Drug: Treatment A|Drug: Treatment B Healthy Adults Tonix Pharmaceuticals Inc. December 16 2015 Phase 1
NCT01921296 Terminated Drug: Cyclobenzaprine Sleep Initiation and Maintenance Disorders|Pain Lynn Henry|Damon Runyon Cancer Research Foundation|University of Michigan Rogel Cancer Center August 2013 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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